The interaction between autophagy and neuroinflammation in major depressive disorder: From pathophysiology to therapeutic implications
Abstract
The past decade has revealed neuroinflammation as an important mechanism of major depressive disorder (MDD). Nod-like receptors family pyrin domain containing 3 (NLRP3) inflammasome is the key regulator interleukin-1β (IL-1β) maturation, whose activation has been reported in MDD patients and various animal models. Function as a dominant driver of neuroinflammation, NLRP3 bridges the gap between immune activation with stress exposure, and further leads to subsequent occurrence of neuropsychiatric disorders such as MDD. Of note, autophagy is a tightly regulated cellular degradation pathway that removes damaged organelles and intracellular pathogens, and maintains cellular homeostasis from varying insults. Serving as a critical cellular monitoring system, normal functioned autophagy signaling prevents excessive NLRP3 inflammasome activation and subsequent release of IL-1 family cytokines. This review will describe the current understanding of how autophagy regulates NLRP3 inflammasome activity and discuss the implications of this regulation on the pathogenesis of MDD. The extensive crosstalk between autophagy pathway and NLRP3 inflammasome is further discussed, as it is critical for developing new therapeutic strategies for MDD aimed at modulating the neuroinflammatory responses.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neuroinflammation is an important component mechanism in the development of depression.
“Neuroinflammation is an important component mechanism in the development of depression.”
From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [40]
Cites
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works
The contemporary refugee crisis: an overview of mental health challenges
Silove, D., Ventevogel, P., & Rees, S. (2017) · World Psychiatry · doi:10.1002/wps.20438 · Cited by 775 · see citing works
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
Maejima, I., Takahashi, A., Omori, H., Kimura, T., Takabatake, Y., Saitoh, T., Yamamoto, A., Hamasaki, M., Noda, T., Isaka, Y., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.171 · Cited by 642 · see citing works
Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
Cho, M.-H., Cho, K., Kang, H.-J., Jeon, E.-Y., Kim, H.-S., Kwon, H.-J., Kim, H.-M., Kim, D.-H., & Yoon, S.-Y. (2014) · Autophagy · doi:10.4161/auto.29647 · Cited by 395 · see citing works
Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works
Modulation of Autophagy by BDNF Underlies Synaptic Plasticity
Nikoletopoulou, V., Sidiropoulou, K., Kallergi, E., Dalezios, Y., & Tavernarakis, N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.005 · Cited by 280 · see citing works
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Ives, A., Nomura, J., Martinon, F., Roger, T., LeRoy, D., Miner, J. N., Simon, G., Busso, N., & So, A. (2015) · Nature Communications · doi:10.1038/ncomms7555 · Cited by 264 · see citing works
Sanchez-Varo, R., Trujillo-Estrada, L., Sanchez-Mejias, E., Torres, M., Baglietto-Vargas, D., Moreno-Gonzalez, I., De Castro, V., Jimenez, S., Ruano, D., Vizuete, M., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0896-x · Cited by 222 · see citing works
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses
Stavoe, A. K. H., Kargbo-Hill, S. E., Hall, D. H., & Colón-Ramos, D. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.012 · Cited by 211 · see citing works
Norman, G. J., Karelina, K., Zhang, N., Walton, J. C., Morris, J. S., & DeVries, A. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.91 · Cited by 209 · see citing works
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
Sharma, M., Rajendrarao, S., Shahani, N., Ramírez-Jarquín, U. N., & Subramaniam, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002144117 · Cited by 155 · see citing works
Jiang, P., Guo, Y., Dang, R., Yang, M., Liao, D., Li, H., Sun, Z., Feng, Q., & Xu, P. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1013-4 · Cited by 139 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Xian, X., Cai, L.-L., Li, Y., Wang, R.-C., Xu, Y.-H., Chen, Y.-J., Xie, Y.-H., Zhu, X.-L., & Li, Y.-F. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01332-w · Cited by 169 · see citing works
- Authors
- Tang, M., Liu, T., Jiang, P., & Dang, R.
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 168
- Pages
- 105586
- ISSN
- 1043-6618
- Cited by
- 81
- References
- 13
- Language
- en
- Licence
- Funders
- National Natural Science Foundation of China
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
