KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works

The structure of the nervous system of the nematode <i>Caenorhabditis elegans</i>

White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · see citing works

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,549 · see citing works

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268 · see citing works

The machinery of macroautophagy

Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083 · see citing works

A ubiquitin-like system mediates protein lipidation

Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., et al. (2000) · Nature · doi:10.1038/35044114 · Cited by 2,064 · see citing works

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145 · see citing works

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in <i>Saccharomyces cerevisiae</i>

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004 · see citing works

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881 · see citing works

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

Young, A. R. J., Chan, E. Y. W., Hu, X. W., Köchl, R., Crawshaw, S. G., High, S., Hailey, D. W., Lippincott-Schwartz, J., & Tooze, S. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03172 · Cited by 815 · see citing works

Protein Turnover Via Autophagy: Implications for Metabolism

Mizushima, N., & Klionsky, D. J. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093749 · Cited by 793 · see citing works

GFP Reconstitution Across Synaptic Partners (GRASP) Defines Cell Contacts and Synapses in Living Nervous Systems

Feinberg, E. H., VanHoven, M. K., Bendesky, A., Wang, G., Fetter, R. D., Shen, K., & Bargmann, C. I. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.030 · Cited by 723 · see citing works

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

Maday, S., Wallace, K. E., & Holzbaur, E. L. F. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201106120 · Cited by 681 · see citing works

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

Yamamoto, H., Kakuta, S., Watanabe, T. M., Kitamura, A., Sekito, T., Kondo-Kakuta, C., Ichikawa, R., Kinjo, M., & Ohsumi, Y. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201202061 · Cited by 659 · see citing works

Mechanisms and Molecules of Neuronal Wiring: A PrimerPreprint

Kolodkin, A. L., & Tessier‐Lavigne, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001727 · Cited by 626 · see citing works

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614 · see citing works

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

Tsukamoto, S., Kuma, A., Murakami, M., Kishi, C., Yamamoto, A., & Mizushima, N. (2008) · Science · doi:10.1126/science.1154822 · Cited by 613 · see citing works

Mechanisms of Selective Autophagy

Zaffagnini, G., & Martens, S. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.02.004 · Cited by 591 · see citing works

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

Orsi, A., Razi, M., Dooley, H. C., Robinson, D. J., Weston, A., Collinson, L., & Tooze, S. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0746 · Cited by 570 · see citing works

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans

Hall, D. H., & Hedgecock, E. M. (1991) · Cell · doi:10.1016/0092-8674(91)90391-b · Cited by 564 · see citing works

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

Dickinson, D. J., Pani, A. M., Heppert, J. K., Higgins, C. D., & Goldstein, B. (2015) · Genetics · doi:10.1534/genetics.115.178335 · Cited by 546 · see citing works

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

Rawi, S. A., Louvet‐Vallée, S., Djeddi, A., Sachse, M., Culetto, E., Hajjar, C., Boyd, L., Legouis, R., & Galy, V. (2011) · Science · doi:10.1126/science.1211878 · Cited by 505 · see citing works

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

Ashrafi, G., Schlehe, J. S., LaVoie, M. J., & Schwarz, T. L. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201401070 · Cited by 502 · see citing works

The Atg1-Atg13 Complex Regulates Atg9 and Atg23 Retrieval Transport from the Pre-Autophagosomal Structure

Reggiori, F., Tucker, K. A., Stromhaug, P. E., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00402-7 · Cited by 476 · see citing works

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

Sato, M., & Sato, K. (2011) · Science · doi:10.1126/science.1210333 · Cited by 469 · see citing works

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

Lamark, T., Kirkin, V., Dikic, I., & Johansen, T. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8892 · Cited by 464 · see citing works

FINE STRUCTURE OF NERVE FIBERS AND GROWTH CONES OF ISOLATED SYMPATHETIC NEURONS IN CULTURE

Bunge, M. B. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.56.3.713 · Cited by 445 · see citing works

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

Tian, Y., Li, Z., Hu, W., Ren, H., Tian, E., Zhao, Y., Lu, Q., Huang, X., Yang, P., Li, X., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.034 · Cited by 434 · see citing works

Autophagic Processes in Yeast: Mechanism, Machinery and Regulation

Reggiori, F., & Klionsky, D. J. (2013) · Genetics · doi:10.1534/genetics.112.149013 · Cited by 404 · see citing works

Apg9p/Cvt7p Is an Integral Membrane Protein Required for Transport Vesicle Formation in the Cvt and Autophagy Pathways

Noda, T., Kim, J., Huang, W., Baba, M., Tokunaga, C., Ohsumi, Y., & Klionsky, D. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.465 · Cited by 392 · see citing works

The million mutation project: A new approach to genetics in Caenorhabditis elegansPreprint

Thompson, O. A., Edgley, M. L., Strasbourger, P., Flibotte, S., Ewing, B., Adair, R., Au, V., Chaudhry, I., Fernando, L., Hutter, H., et al. (2013) · Genome Research · doi:10.1101/gr.157651.113 · Cited by 388 · see citing works

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

Maday, S., & Holzbaur, E. L. F. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.001 · Cited by 372 · see citing works

Regulation of Presynaptic Neurotransmission by Macroautophagy

Hernandez, D., Torres, C. A., Setlik, W., Cebrián, C., Mosharov, E. V., Tang, G., Cheng, H., Kholodilov, N. G., Yarygina, O., Burke, R. E., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.020 · Cited by 348 · see citing works

Neuronal autophagy and neurodegenerative diseases

Son, J., Shim, J., Kim, K.-H., Ha, J., & Han, J.-Y. (2012) · Experimental and Molecular Medicine · doi:10.3858/emm.2012.44.2.031 · Cited by 342 · see citing works

Autophagy

Hale, A. N., Ledbetter, D., Gawriluk, T. R., & Rucker, E. B. (2013) · Autophagy · doi:10.4161/auto.24273 · Cited by 336 · see citing works

The Immunoglobulin Superfamily Protein SYG-1 Determines the Location of Specific Synapses in C. elegans

Shen, K., & Bargmann, C. I. (2003) · Cell · doi:10.1016/s0092-8674(03)00113-2 · Cited by 330 · see citing works

Rapid single nucleotide polymorphism mapping in C. elegans

Davis, M. W., Hammarlund, M., Harrach, T., Hullett, P., Olsen, S. R., & Jørgensen, E. M. (2005) · BMC Genomics · doi:10.1186/1471-2164-6-118 · Cited by 324 · see citing works

Posttranslational modification of autophagy-related proteins in macroautophagy

Xie, Y., Kang, R., Sun, X., Zhong, M., Huang, J. L., Klionsky, D. J., & Tang, D. (2014) · Autophagy · doi:10.4161/15548627.2014.984267 · Cited by 309 · see citing works

Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport.

Hollenbeck, P. J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.2.305 · Cited by 295 · see citing works

Human Apg3p/Aut1p Homologue Is an Authentic E2 Enzyme for Multiple Substrates, GATE-16, GABARAP, and MAP-LC3, and Facilitates the Conjugation of hApg12p to hApg5p

Tanida, I., Tanida-Miyake, E., Komatsu, M., Ueno, T., & Kominami, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200385200 · Cited by 286 · see citing works

Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans

Colón-Ramos, D., Margeta, M. A., & Shen, K. (2007) · Science · doi:10.1126/science.1143762 · Cited by 284 · see citing works

Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy

Cullup, T., Kho, A. L., Dionisi‐Vici, C., Brandmeier, B., Smith, F., Urry, Z., Simpson, M. A., Yau, S., Bertini, E., McClelland, V. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2497 · Cited by 282 · see citing works

Atg11 Links Cargo to the Vesicle-forming Machinery in the Cytoplasm to Vacuole Targeting Pathway

Yorimitsu, T., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1035 · Cited by 280 · see citing works

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

Yu, W. H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B. T., Cuervo, A. M., & Nixon, R. A. (2004) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2004.05.010 · Cited by 279 · see citing works

Aut2p and Aut7p, two novel microtubule‐associated proteins are essential for delivery of autophagic vesicles to the vacuole

Lang, T., Schaeffeler, E., Bernreuther, D., Bredschneider, M., Wolf, D. H., & Thumm, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3597 · Cited by 254 · see citing works

Autophagy promotes synapse development in <i>Drosophila</i>

Shen, W., & Ganetzky, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907109 · Cited by 252 · see citing works

The Scaffold Protein Atg11 Recruits Fission Machinery to Drive Selective Mitochondria Degradation by Autophagy

Mao, K., Wang, K., Liu, X., & Klionsky, D. J. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.05.024 · Cited by 247 · see citing works

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

Zhang, Y., Yan, L., Zhou, Z., Yang, P., Tian, E., Zhang, K., Zhao, Y., Li, Z., Song, B., Han, J., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.022 · Cited by 237 · see citing works

Caenorhabditis elegans mutant allele identification by whole-genome sequencing

Sarin, S., Prabhu, S., O’Meara, M., Pe’er, I., & Hobert, O. (2008) · Nature Methods · doi:10.1038/nmeth.1249 · Cited by 237 · see citing works

The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

Lu, Q., Yang, P., Huang, X., Hu, W., Guo, B., Wu, F., Lin, L., Kovács, A. L., Yu, L., & Zhang, H. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.024 · Cited by 236 · see citing works

UNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans

Byrd, D. T., Kawasaki, M., Walcoff, M., Hisamoto, N., Matsumoto, K., & Jin, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00532-3 · Cited by 234 · see citing works

Assortment of Phosphatidylinositol 3-Kinase Complexes—Atg14p Directs Association of Complex I to the Pre-autophagosomal Structure inSaccharomyces cerevisiae

Obara, K., Sekito, T., & Ohsumi, Y. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0841 · Cited by 229 · see citing works

Guidance Molecules in Synapse Formation and PlasticityPreprint

Shen, K., & Cowan, C. W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001842 · Cited by 227 · see citing works

Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast

He, C., Song, H., Yorimitsu, T., Monastyrska, I., Yen, W.-L., Legakis, J. E., & Klionsky, D. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606084 · Cited by 219 · see citing works

The C. elegans unc-104 4 gene encodes a putative kinesin heavy chain-like protein

Otsuka, A. J., Jeyaprakash, A., Garcı́a-Añoveros, J., Tang, L., Fisk, G. J., Hartshorne, T. A., Franco, R., & Bornt, T. (1991) · Neuron · doi:10.1016/0896-6273(91)90126-k · Cited by 217 · see citing works

Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans

Smith, C. J., Watson, J. D., Spencer, W. C., O’Brien, T., Cha, B., Albeg, A., Treinin, M., & Miller, D. M. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.05.502 · Cited by 210 · see citing works

Autophagy and Its Normal and Pathogenic States in the Brain

Yamamoto, A., & Yue, Z. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014149 · Cited by 204 · see citing works

Autophagy for tissue homeostasis and neuroprotection

Mariño, G., Madeo, F., & Kroemer, G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.001 · Cited by 195 · see citing works

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

Binotti, B., Pavlos, N. J., Riedel, D., Wenzel, D., Vorbrüggen, G., Schalk, A. M., Kühnel, K., Boyken, J., Erck, C., Martens, H., et al. (2015) · eLife · doi:10.7554/elife.05597 · Cited by 193 · see citing works

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development

DeLuca, S. Z., & O’Farrell, P. H. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.021 · Cited by 188 · see citing works

Neuronal macroautophagy: from development to degeneration.

Boland, B., & Nixon, R. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.009 · Cited by 181 · see citing works

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

Yue, Z., Friedman, L. G., Komatsu, M., & Tanaka, K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.01.016 · Cited by 173 · see citing works

Getting ready for building: signaling and autophagosome biogenesis

Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 171 · see citing works

Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation

Suzuki, S. W., Yamamoto, H., Oikawa, Y., Kondo‐Kakuta, C., Kimura, Y., Hirano, H., & Ohsumi, Y. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421092112 · Cited by 171 · see citing works

UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting

Maniar, T. A., Kaplan, M. R., Wang, G. J., Shen, K., Wei, L., Shaw, J. E., Koushika, S. P., & Bargmann, C. I. (2011) · Nature Neuroscience · doi:10.1038/nn.2970 · Cited by 168 · see citing works

Untitled work

(1987) · Europe PMC (PubMed Central) · Cited by 168 · see citing works

Apg2 Is a Novel Protein Required for the Cytoplasm to Vacuole Targeting, Autophagy, and Pexophagy Pathways

Wang, C.-W., Kim, J., Huang, W., Abeliovich, H., STRØMHAUG, P. E., Dunn, W. A., & Klionsky, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102342200 · Cited by 166 · see citing works

Regulation of Synaptic Transmission by RAB-3 and RAB-27 inCaenorhabditis elegans

Mahoney, T. R., Liu, Q., Itoh, T., Luo, S., Hadwiger, G., Vincent, R., Wang, Z., Fukuda, M., & Nonet, M. L. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-12-1170 · Cited by 166 · see citing works

Guidelines for monitoring autophagy in Caenorhabditis elegans

Zhang, H., Chang, J. T., Guo, B., Hansen, M., Jia, K.-L., Kovács, A. L., Kumsta, C., Lapierre, L. R., Legouis, R., Lin, L., et al. (2015) · Autophagy · doi:10.1080/15548627.2014.1003478 · Cited by 160 · see citing works

Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

Farré, J., Burkenroad, A., Burnett, S. F., & Subramani, S. E. (2013) · EMBO Reports · doi:10.1038/embor.2013.40 · Cited by 159 · see citing works

The C. elegans LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39

Manil-Ségalen, M., Lefebvre, C., Jenzer, C., Trichet, M., Boulogne, C., Satiat‐Jeunemaître, B., & Legouis, R. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.11.022 · Cited by 154 · see citing works

Control of Autophagosome Axonal Retrograde Flux by Presynaptic Activity Unveiled Using Botulinum Neurotoxin Type A

Wang, T., Martin, S., Papadopulos, A., Harper, C. B., Mavlyutov, T. A., Niranjan, D., Glass, N. R., Cooper-White, J. J., Sibarita, J., Choquet, D., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3757-14.2015 · Cited by 151 · see citing works

Regulation of autophagy: Modulation of the size and number of autophagosomes

Jin, M., & Klionsky, D. J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.06.015 · Cited by 148 · see citing works

The Balance between Capture and Dissociation of Presynaptic Proteins Controls the Spatial Distribution of Synapses

Wu, Y., Huo, L., Maeder, C. I., Feng, W., & Shen, K. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.035 · Cited by 144 · see citing works

Autophagy in axonal and dendritic degeneration

Yang, Y., Coleman, M. P., Zhang, L., Zheng, X., & Yue, Z. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.001 · Cited by 144 · see citing works

Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure

Shintani, T., Suzuki, K., Kamada, Y., Noda, T., & Ohsumi, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102346200 · Cited by 138 · see citing works

Regulation of Neuronal Autophagy in Axon: Implication of Autophagy in Axonal Function and Dysfunction/Degeneration

Yue, Z. (2007) · Autophagy · doi:10.4161/auto.3602 · Cited by 130 · see citing works

Ypt1 recruits the Atg1 kinase to the preautophagosomal structure

Wang, J., Menon, S., Yamasaki, A., Chou, H., Walz, T., Jiang, Y., & Ferro‐Novick, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302337110 · Cited by 129 · see citing works

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration

Zhao, H., Zhao, Y. G., Wang, X., Xu, L., Miao, L., Feng, D., Chen, Q., Kovács, A. L., Fan, D., & Zhang, H. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201211014 · Cited by 128 · see citing works

Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival?

Lee, J.-A. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.1.1 · Cited by 119 · see citing works

TheCaenorhabditis elegansUNC-14 RUN Domain Protein Binds to the Kinesin-1 and UNC-16 Complex and Regulates Synaptic Vesicle Localization

Kajino‐Sakamoto, R., Byrd, D. T., Brown, H. M., Hisamoto, N., Matsumoto, K., & Jin, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0553 · Cited by 117 · see citing works

Autophagosome dynamics in neurodegeneration at a glance

Wong, Y. C., & Holzbaur, E. L. F. (2015) · Journal of Cell Science · doi:10.1242/jcs.161216 · Cited by 116 · see citing works

Autophagy in C. elegans.

Meléndez, A., & Levine, B. (2009) · WormBook · doi:10.1895/wormbook.1.147.1 · Cited by 112 · see citing works

Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders

Xilouri, M., & Stefanis, L. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710793237421 · Cited by 107 · see citing works

Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy

Wu, F., Watanabe, Y., Guo, X., Qi, X., Wang, P., Zhao, H., Wang, Z., Fujioka, Y., Hui, Z., Jin-Qi, R. E. N., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.019 · Cited by 103 · see citing works

Eaten alive: novel insights into autophagy from multicellular model systems

Zhang, H., & Baehrecke, E. H. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.03.001 · Cited by 102 · see citing works

Neuronal Autophagy and Neurodevelopmental Disorders

Lee, K., Hwang, S.-K., & Lee, J. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.3.133 · Cited by 101 · see citing works

Autophagy and the cvt Pathway Both Depend on AUT9

Lang, T., Reiche, S., Straub, M., Bredschneider, M., & Thumm, M. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.8.2125-2133.2000 · Cited by 101 · see citing works

Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter

Yang, H., Mains, P. E., & McNally, F. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411132 · Cited by 97 · see citing works

Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain

Patel, N., Thierry-Mieg, D., & Mancillas, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9181 · Cited by 96 · see citing works

Autophagy Negatively Regulates Early Axon Growth in Cortical Neurons

Ban, B.-K., Jun, M.-H., Ryu, H.-H., Jang, D., Ahmad, S. T., & Lee, J. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00627-13 · Cited by 95 · see citing works

MAQGene: software to facilitate C. elegans mutant genome sequence analysis

Bigelow, H., Doitsidou, M., Sarin, S., & Hobert, O. (2009) · Nature Methods · doi:10.1038/nmeth.f.260 · Cited by 95 · see citing works

Rapidly transported organelles containing membrane and cytoskeletal components: their relation to axonal growth.

Hollenbeck, P. J., & Bray, D. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.6.2827 · Cited by 94 · see citing works

The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans

Alberti, A., Michelet, X., Djeddi, A., & Legouis, R. (2010) · Autophagy · doi:10.4161/auto.6.5.12252 · Cited by 92 · see citing works

The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51.Preprint

Ogura, K., Shirakawa, M., Barnes, T. M., Hekimi, S., & Ohshima, Y. (1997) · Genes & Development · doi:10.1101/gad.11.14.1801 · Cited by 88 · see citing works

The beginning of the end: how scaffolds nucleate autophagosome biogenesis

Stanley, R. E., Ragusa, M. J., & Hurley, J. H. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.008 · Cited by 86 · see citing works

The actin cytoskeleton in presynaptic assembly

Nelson, J. C., Stavoe, A. K., & Colón‐Ramos, D. A. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.24803 · Cited by 83 · see citing works

Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation

Feng, Y., Backues, S. K., Baba, M., Heo, J.-M., Harper, J. W., & Klionsky, D. J. (2016) · Autophagy · doi:10.1080/15548627.2016.1157237 · Cited by 81 · see citing works

Synapse Location during Growth Depends on Glia Location

Shao, Z., Watanabe, S., Christensen, R. P., Jørgensen, E. M., & Colón‐Ramos, D. A. (2013) · Cell · doi:10.1016/j.cell.2013.06.028 · Cited by 80 · see citing works

The scaffold protein EPG-7 links cargo–receptor complexes with the autophagic assembly machinery

Lin, L., Yang, P., Huang, X., Zhang, H., Lu, Q., & Zhang, H. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201209098 · Cited by 75 · see citing works

Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles

Abe, N., Almenar‐Queralt, A., Lillo, C., Shen, Z., Lozach, J., Briggs, S. P., Williams, D. S., Goldstein, L. S. B., & Cavalli, V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035022 · Cited by 65 · see citing works

A Novel Role for Autophagy in Neurodevelopment

Cecconi, F., Bartolomeo, S. D., Nardacci, R., Fuoco, C., Corazzari, M., Giunta, L., Romagnoli, A., Stoykova, A., Chowdhury, K., Fimia, G. M., et al. (2007) · Autophagy · doi:10.4161/auto.4616 · Cited by 63 · see citing works

The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans

Lai, T. S., & Garriga, G. (2004) · Development · doi:10.1242/dev.01457 · Cited by 62 · see citing works

PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation

Wu, Y., Cheng, S., Zhao, H., Zou, W., Yoshina, S., Mitani, S., Zhang, H., & Wang, X. (2014) · EMBO Reports · doi:10.15252/embr.201438618 · Cited by 62 · see citing works

Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton

Stavoe, A. K., & Colón‐Ramos, D. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201110127 · Cited by 60 · see citing works

Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth

Chen, J., Sun, Y., Wang, P., Long, D., Li, W., Li, L., & Wu, Y. (2013) · Toxicology · doi:10.1016/j.tox.2013.05.012 · Cited by 58 · see citing works

Basic Caenorhabditis elegans Methods: Synchronization and Observation

Porta-de-la-Riva, M., Fontrodona, L., Villanueva, A., & Cerón, J. (2012) · Journal of Visualized Experiments · doi:10.3791/4019-v · Cited by 58 · see citing works

Differential Function of the Two Atg4 Homologues in the Aggrephagy Pathway in Caenorhabditis elegans

Wu, F., Li, Y., Wang, F., Noda, N. N., & Zhang, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365676 · Cited by 57 · see citing works

InvestigatingC. elegansdevelopment through mosaic analysis

Yochem, J., & Herman, R. K. (2003) · Development · doi:10.1242/dev.00701 · Cited by 54 · see citing works

Autophagy regulation through Atg9 traffic

Reggiori, F., & Tooze, S. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201206119 · Cited by 52 · see citing works

Autophagy and mammalian development

Wu, X., Won, H., & Rubinsztein, D. C. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130185 · Cited by 49 · see citing works

Atg9A Protein, an Autophagy-related Membrane Protein, Is Localized in the Neurons of Mouse Brains

Tamura, H., Shibata, M., Koike, M., Sasaki, M., & Uchiyama, Y. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955690 · Cited by 49 · see citing works

The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans

Yang, P.-G., & Zhang, H. (2011) · Autophagy · doi:10.4161/auto.7.2.14223 · Cited by 42 · see citing works

The JIP3 scaffold protein UNC‐16 regulates RAB‐5 dependent membrane trafficking at C. elegans synapses

Brown, H. M., Epps, H. A. V., Goncharov, A., Grant, B. D., & Jin, Y. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20690 · Cited by 40 · see citing works

The twoC. elegansATG-16 homologs have partially redundant functions in the basal autophagy pathway

Zhang, H., Wu, F., Wang, X., Du, H., Wang, X., & Zhang, H. (2013) · Autophagy · doi:10.4161/auto.26095 · Cited by 38 · see citing works

You are what you eat: multifaceted functions of autophagy during C. elegans development

Yang, P.-G., & Zhang, H. (2013) · Cell Research · doi:10.1038/cr.2013.154 · Cited by 38 · see citing works

Transcriptional regulation ofATG9by the Pho23-Rpd3 complex modulates the frequency of autophagosome formation

Jin, M., & Klionsky, D. J. (2014) · Autophagy · doi:10.4161/auto.29641 · Cited by 37 · see citing works

Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from NetrinPreprint

Stavoe, A. K., Nelson, J. C., Martinez-Velazquez, L., Klein, M., Samuel, A. D. T., & Colón‐Ramos, D. A. (2012) · Genes & Development · doi:10.1101/gad.193409.112 · Cited by 37 · see citing works

Aggrephagy: lessons from C. elegans

Lu, Q., Wu, F., & Zhang, H. (2013) · Biochemical Journal · doi:10.1042/bj20121721 · Cited by 34 · see citing works

Does autophagy work in synaptic plasticity and memory?

Shehata, M. H., & Inokuchi, K. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0002 · Cited by 32 · see citing works

Double duty of Atg9 self-association in autophagosome biogenesis

He, C., Baba, M., & Klionsky, D. J. (2009) · Autophagy · doi:10.4161/auto.5.3.7699 · Cited by 25 · see citing works

Single-Nucleotide Polymorphism Mapping

Davis, M. W., & Hammarlund, M. (2006) · Humana Press eBooks · doi:10.1385/1-59745-151-7:75 · Cited by 22 · see citing works

Macroautophagy can press a brake on presynaptic neurotransmission

Torres, C. A., & Sulzer, D. L. (2012) · Autophagy · doi:10.4161/auto.21330 · Cited by 19 · see citing works

The impact of autophagy on peripheral synapses in health and disease

Rudolf, R. (2016) · Frontiers in bioscience · doi:10.2741/4467 · Cited by 8 · see citing works

Long-distance autophagy

Ariosa, A., & Klionsky, D. J. (2015) · Autophagy · doi:10.1080/15548627.2015.1009790 · Cited by 6 · see citing works

MOSAIC ANALYSIS IN THE NEMATODE CAENORHABDITIS ELEGANS

Herman, R. K. (2007) · Journal of Neurogenetics · doi:10.1080/01677060701693446 · Cited by 2 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Autophagy in neurons

Stavoe, A. K. H., & Holzbaur, E. L. F. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125242 · Cited by 328 · see citing works

Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

Vos, K. J. D., & Hafezparast, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.004 · Cited by 238 · see citing works

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

Vanhauwaert, R., Kuenen, S., Masius, R., Bademosi, A. T., Manetsberger, J., Schoovaerts, N., Bounti, L., Gontcharenko, S., Swerts, J., Vilain, S., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695773 · Cited by 225 · see citing works

Autophagy and ALS: mechanistic insights and therapeutic implications

Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works

Autophagy and mitophagy in ALS

Evans, C. S., & Holzbaur, E. L. F. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.005 · Cited by 178 · see citing works

Autophagy in the presynaptic compartment in health and disease

Vijayan, V., & Verstreken, P. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611113 · Cited by 167 · see citing works

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes

Boecker, C. A., Goldsmith, J., Dou, D., Cajka, G. G., & Holzbaur, E. L. F. (2021) · Current Biology · doi:10.1016/j.cub.2021.02.061 · Cited by 166 · see citing works

AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

Davies, A. K., Itzhak, D. N., Edgar, J. R., Archuleta, T. L., Hirst, J., Jackson, L. P., Robinson, M. S., & Borner, G. H. H. (2018) · Nature Communications · doi:10.1038/s41467-018-06172-7 · Cited by 153 · see citing works

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

Evans, C. S., & Holzbaur, E. L. (2020) · eLife · doi:10.7554/elife.50260 · Cited by 137 · see citing works

Targeting PI3K-AKT/mTOR signaling in the prevention of autism

Sharma, A., & Mehan, S. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105067 · Cited by 131 · see citing works

The autophagy protein ATG9A enables lipid mobilization from lipid droplets

Mailler, É., Guardia, C. M. A., Bai, X., Jarník, M., Williamson, C. D., Li, Y., Maio, N., Golden, A., & Bonifacino, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-26999-x · Cited by 123 · see citing works

Neuronal autophagy and intercellular regulation of homeostasis in the brain

Kulkarni, A., Chen, J., & Maday, S. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.008 · Cited by 117 · see citing works

Axonal transport and maturation of lysosomes

Ferguson, S. M. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.020 · Cited by 113 · see citing works

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

Gupta, V., Pech, U., Bhukel, A., Fulterer, A., Ender, A., Mauermann, S. F., Andlauer, T. F. M., Antwi-Adjei, E., Beuschel, C. B., Thriene, K., et al. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002563 · Cited by 109 · see citing works

The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy

Deneubourg, C., Ramm, M., Smith, L. J., Baron, O., Singh, K., Byrne, S., Duchen, M. R., Gautel, M., Eskelinen, E., Fanto, M., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1943177 · Cited by 113 · see citing works

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

Cason, S. E., Carman, P. J., Duyne, C. V., Goldsmith, J., Domínguez, R., & Holzbaur, E. L. F. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202010179 · Cited by 108 · see citing works

The Endolysosomal System and Proteostasis: From Development to Degeneration

Winckler, B., Faúndez, V., Maday, S., Cai, Q., Almeida, C. G., & Zhang, H. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1665-18.2018 · Cited by 105 · see citing works

Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms

Evans, C. S., & Holzbaur, E. L. F. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.06.031 · Cited by 105 · see citing works

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

Yang, S., Park, D., Manning, L., Kargbo-Hill, S. E., Cao, M., Zhao, X., Gonzalez, I. J., Dong, Y., Clark, B., Shao, L., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.031 · Cited by 103 · see citing works

Autophagy core machinery: overcoming spatial barriers in neurons

Ariosa, A., & Klionsky, D. J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1461-9 · Cited by 100 · see citing works

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

Ji, C., Tang, M., Zeidler, C., Höhfeld, J., & Johnson, G. (2019) · bioRxiv · doi:10.1080/15548627.2019.1580096 · Cited by 89 · see citing works

Enhancing autophagy in Alzheimer's disease through drug repositioning

Eshraghi, M., Ahmadi, M., Afshar, S., Lorzadeh, S., Adlimoghaddam, A., Rezvani Jalal, N., West, R., Dastghaib, S., Igder, S., Torshizi, S. R. N., et al. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2022.108171 · Cited by 89 · see citing works

The interaction between autophagy and neuroinflammation in major depressive disorder: From pathophysiology to therapeutic implications

Tang, M., Liu, T., Jiang, P., & Dang, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105586 · Cited by 81 · see citing works

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

Stavoe, A. K., Gopal, P. P., Gubas, A., Tooze, S. A., & Holzbaur, E. L. (2019) · eLife · doi:10.7554/elife.44219 · Cited by 82 · see citing works

Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A

Lessard, D. V., Zinder, O. J., Hotta, T., Verhey, K. J., Ohi, R., & Berger, C. L. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005765 · Cited by 85 · see citing works

Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

Ivankovic, D., Drew, J., Lesept, F., White, I. J., López‐Doménech, G., Tooze, S. A., & Kittler, J. T. (2019) · Autophagy · doi:10.1080/15548627.2019.1615302 · Cited by 83 · see citing works

Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking

Behne, R., Teinert, J., Wimmer, M., D’Amore, A., Davies, A. K., Scarrott, J. M., Eberhardt, K., Brechmann, B., Chen, I. P.-F., Buttermore, E. D., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz310 · Cited by 76 · see citing works

The Journey of the Synaptic Autophagosome: A Cell Biological Perspective

Kargbo-Hill, S. E., & Colón-Ramos, D. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.018 · Cited by 72 · see citing works

Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2

Kargbo-Hill, S. E., Kauffman, K. J., Krout, M., Richmond, J. E., Melia, T. J., & Colón‐Ramos, D. A. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.02.013 · Cited by 70 · see citing works

Differential regulation of autophagy during metabolic stress in astrocytes and neurons

Kulkarni, A., Dong, A., Kulkarni, V. V., Chen, J., Laxton, O., Anand, A., & Maday, S. (2019) · Autophagy · doi:10.1080/15548627.2019.1703354 · Cited by 77 · see citing works

MicroRNA-mediated autophagy regulation in cancer therapy: The role in chemoresistance/chemosensitivity

Ashrafizadeh, M., Zarrabi, A., Orouei, S., Hushmandi, K., Hakimi, A., Zabolian, A., Daneshi, S., Samarghandian, S., Baradaran, B., & Najafi, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173660 · Cited by 76 · see citing works

Compartment‐specific dynamics and functions of autophagy in neurons

Kulkarni, V. V., & Maday, S. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22562 · Cited by 72 · see citing works

Autophagy in Astrocytes and its Implications in Neurodegeneration

Sung, K., & Jiménez-Sánchez, M. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.041 · Cited by 74 · see citing works

Autophagy and proteostasis in the control of synapse aging and disease

Liang, Y., & Sigrist, S. J. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.006 · Cited by 72 · see citing works

Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia

Gabrych, D. R., Lau, V. Z., Niwa, S., & Silverman, M. A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00419 · Cited by 71 · see citing works

Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders

Tomoda, T., Yang, K., & Sawa, A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.018 · Cited by 71 · see citing works

Regulation of neuronal autophagy and the implications in neurodegenerative diseases

Cai, Q., & Ganesan, D. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105582 · Cited by 67 · see citing works

Axonal autophagy: Mini-review for autophagy in the CNS

Stavoe, A. K., & Holzbaur, E. L. F. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.025 · Cited by 71 · see citing works

Autophagy deficiency in neurodevelopmental disorders

Deng, Z., Zhou, X., Lu, J., & Yue, Z. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00726-x · Cited by 64 · see citing works

The Synaptic Autophagy Cycle

Lieberman, O. J., & Sulzer, D. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.028 · Cited by 65 · see citing works

Presynaptic protein homeostasis and neuronal function

Wang, Y., Lauwers, E., & Verstreken, P. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.01.015 · Cited by 58 · see citing works

Emerging Concepts and Functions of Autophagy as a Regulator of Synaptic Components and Plasticity

Liang, Y. (2019) · Cells · doi:10.3390/cells8010034 · Cited by 60 · see citing works

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

Kiral, F. R., Linneweber, G. A., Mathejczyk, T. F., Georgiev, S. V., Wernet, M. F., Hassan, B. A., von Kleist, M., & Hiesinger, P. R. (2020) · Nature Communications · doi:10.1038/s41467-020-14781-4 · Cited by 59 · see citing works

The developmental biology of kinesins

Konjikusic, M. J., Gray, R. S., & Wallingford, J. B. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.09.009 · Cited by 57 · see citing works

Synaptic activity controls autophagic vacuole motility and function in dendrites

Kulkarni, V. V., Anand, A., Herr, J. B., Miranda, C., Vogel, M. C., & Maday, S. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202002084 · Cited by 59 · see citing works

Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology

Valencia, M., Kim, S. R., Jang, Y., & Lee, S. H. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.012 · Cited by 55 · see citing works

Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases

Cason, S. E., & Holzbaur, E. L. F. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202301084 · Cited by 53 · see citing works

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse

Overhoff, M., Tellkamp, F., Heß, S., Tutas, J., Tolve, M., Faerfers, M., Ickert, L., Mohammadi, M., Bruyckere, E. D., Kallergi, E., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022110963 · Cited by 50 · see citing works

Interdependency Between Autophagy and Synaptic Vesicle Trafficking: Implications for Dopamine Release

Limanaqi, F., Biagioni, F., Gambardella, S., Ryskalin, L., & Fornai, F. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00299 · Cited by 49 · see citing works

Autophagy and the endolysosomal system in presynaptic function

Andres‐Alonso, M., Kreutz, M. R., & Karpova, A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03722-5 · Cited by 48 · see citing works

Autophagy in C. elegans development

Palmisano, N. J., & Meléndez, A. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.04.009 · Cited by 48 · see citing works

Autophagy at the synapse

Birdsall, V., & Waites, C. L. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.033 · Cited by 48 · see citing works

Autophagy is inhibited by ubiquitin ligase activity in the nervous system

Crawley, O., Opperman, K. J., Desbois, M., Adrados, I., Borgen, M. A., Giles, A. C., Duckett, D. R., & Grill, B. J. (2019) · Nature Communications · doi:10.1038/s41467-019-12804-3 · Cited by 45 · see citing works

Dysfunctional Autophagy and Endolysosomal System in Neurodegenerative Diseases: Relevance and Therapeutic Options

Giovedı̀, S., Ravanelli, M. M., Parisi, B., Bettegazzi, B., & Guarnieri, F. C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.602116 · Cited by 49 · see citing works

Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

Lieberman, O. J., Frier, M. D., McGuirt, A. F., Griffey, C. J., Rafikian, E. E., Yang, M., Yamamoto, A., Borgkvist, A., Santini, E., & Sulzer, D. (2020) · eLife · doi:10.7554/elife.50843 · Cited by 45 · see citing works

mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update

Limanaqi, F., Biagioni, F., Busceti, C. L., Fabrizi, C., Frati, A., & Fornai, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051642 · Cited by 46 · see citing works

Neuronal Autophagy: Regulations and Implications in Health and Disease

Liénard, C., Pintart, A., & Bomont, P. (2024) · Cells · doi:10.3390/cells13010103 · Cited by 44 · see citing works

Neuronal autophagy in the control of synapse function

Karpova, A., Hiesinger, P. R., Kuijpers, M., Albrecht, A., Kirstein, J., Andres‐Alonso, M., Biermeier, A. J., Eickholt, B. J., Mikhaylova, M., Maglione, M., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.019 · Cited by 46 · see citing works

mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders

Lieberman, O. J., Cartocci, V., Pigulevskiy, I., Molinari, M., Carbonell, J., Broseta, M. B., Post, M. R., Sulzer, D., Borgkvist, A., & Santini, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00070 · Cited by 47 · see citing works

Organization of the autophagy pathway in neurons

Sidibe, D. K., Vogel, M. C., & Maday, S. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102554 · Cited by 38 · see citing works

Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

Li, J., Zhang, Y. V., Adib, E. A., Stanchev, D., Xiong, X., Klinedinst, S., Soppina, P., Jahn, T. R., Hume, R. I., Rasse, T. M., et al. (2017) · eLife · doi:10.7554/elife.24271 · Cited by 44 · see citing works

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Griffin, E. F., Scopel, S. E., Stephen, C. A., Holzhauer, A. C., Vaji, M. A., Tuckey, R. A., Berkowitz, L. A., Caldwell, K. A., & Caldwell, G. A. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037218 · Cited by 44 · see citing works

Absence of Sac2/INPP5F enhances the phenotype of a Parkinson’s disease mutation of synaptojanin 1

Cao, M., Park, D., Wu, Y., & Camilli, P. V. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004335117 · Cited by 42 · see citing works

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

Shen, H., Zhu, H., Panja, D., Gu, Q., & Li, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-16794-5 · Cited by 43 · see citing works

Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies

Haidar, M., & Timmerman, V. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00143 · Cited by 39 · see citing works

Mechanisms of neuronal survival safeguarded by endocytosis and autophagy

Overhoff, M., Bruyckere, E. D., & Kononenko, N. L. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15194 · Cited by 38 · see citing works

Molecular Mechanism and Regulation of Autophagy and Its Potential Role in Epilepsy

Zhu, H., Wang, W., & Li, Y. (2022) · Cells · doi:10.3390/cells11172621 · Cited by 41 · see citing works

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes

Dou, D., Smith, E. M., Evans, C. S., Boecker, C. A., & Holzbaur, E. L. F. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112448 · Cited by 36 · see citing works

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

Marchesi, L. T., Leblanc, M., & Stévanin, G. (2021) · Cells · doi:10.3390/cells10071678 · Cited by 34 · see citing works

Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury

Petrova, V., Nieuwenhuis, B., Fawcett, J. W., & Eva, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041798 · Cited by 33 · see citing works

Autophagy in the presynaptic compartment

Lüningschrör, P., & Sendtner, M. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.023 · Cited by 31 · see citing works

Autophagy and lysosomal pathways in nervous system disorders

Bingol, B. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.04.009 · Cited by 31 · see citing works

Autophagy in development and regeneration: role in tissue remodelling and cell survival

Tettamanti, G., Carata, E., Montali, A., Dini, L., & Fimia, G. M. (2019) · The European Zoological Journal · doi:10.1080/24750263.2019.1601271 · Cited by 31 · see citing works

An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior

Buddell, T., Friedman, V., Drozd, C. J., & Quinn, C. C. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008488 · Cited by 31 · see citing works

Spatiotemporal analysis of axonal autophagosome–lysosome dynamics reveals limited fusion events and slow maturation

Cason, S. E., Mogre, S. S., Holzbaur, E. L. F., & Koslover, E. F. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-03-0111 · Cited by 31 · see citing works

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

Binotti, B., Ninov, M., Cepeda, A. P., Ganzella, M., Matti, U., Riedel, D., Urlaub, H., Sambandan, S., & Jahn, R. (2023) · Autophagy · doi:10.1080/15548627.2023.2274204 · Cited by 30 · see citing works

Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity

Bai, I., Keyser, C., Zhang, Z., Rosolia, B. J., Hwang, J.-Y., Zukin, R. S., & Yan, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1322842 · Cited by 30 · see citing works

The effects of proteasome on baseline and methamphetamine-dependent dopamine transmission

Limanaqi, F., Biagioni, F., Busceti, C. L., Ryskalin, L., & Fornai, F. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.008 · Cited by 29 · see citing works

Aging Differentially Affects Axonal Autophagosome Formation and Maturation

Tsong, H., Holzbaur, E. L. F., & Stavoe, A. K. (2023) · Autophagy · doi:10.1080/15548627.2023.2236485 · Cited by 28 · see citing works

Emerging roles of ATG9/ATG9A in autophagy: implications for cell and neurobiology

Choi, J., Jang, H., Xuan, Z., & Park, D. (2024) · Autophagy · doi:10.1080/15548627.2024.2384349 · Cited by 28 · see citing works

Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation

Boecker, C. A., & Holzbaur, E. L. F. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.005 · Cited by 28 · see citing works

KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3β signaling

Zhou, Y., Yang, L., Xiong, L., Wang, K., Hou, X., Li, Q., Kong, F., Liu, X., & He, J. (2021) · Journal of Cancer · doi:10.7150/jca.52103 · Cited by 27 · see citing works

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Jiménez-Moreno, N., & Lane, J. D. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8865611 · Cited by 26 · see citing works

Cross Talk at the Cytoskeleton–Plasma Membrane Interface: Impact on Neuronal Morphology and Functions

Giaimo, R. D., Penna, E., Pizzella, A., Cirillo, R., Perrone‐Capano, C., & Crispino, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239133 · Cited by 24 · see citing works

Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons

Kulkarni, V. V., Stempel, M. H., Anand, A., Sidibe, D. K., & Maday, S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1292-22.2022 · Cited by 26 · see citing works

Synaptogenesis: unmasking molecular mechanisms using Caenorhabditis elegans

Mizumoto, K., Jin, Y., & Bessereau, J. (2023) · Genetics · doi:10.1093/genetics/iyac176 · Cited by 26 · see citing works

Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons

Jia, N., Ganesan, D., Guan, H., Jeong, Y. Y., Han, S., Rajapaksha, G., Nissenbaum, M., Kusnecov, A. W., & Cai, Q. (2024) · Autophagy · doi:10.1080/15548627.2024.2392408 · Cited by 26 · see citing works

The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy

Zhao, X., Yang, S., Kargbo-Hill, S. E., Clark, B., Manning, L., & Colón‐Ramos, D. A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002030 · Cited by 22 · see citing works

Intrinsic and extrinsic mechanisms of synapse formation and specificity in C. elegans

Hendi, A., Kurashina, M., & Mizumoto, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03109-1 · Cited by 20 · see citing works

Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena

Kiss, V., Jipa, A., Varga, K., Takáts, S., Maruzs, T., Lőrincz, P., Simon‐Vecsei, Z., Szikora, S., Földi, I., Bajusz, C., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0452-0 · Cited by 25 · see citing works

Autophagy at synapses in neurodegenerative diseases

Lee, W., & Kim, S. H. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01148-7 · Cited by 23 · see citing works

The Role of LRRK2 in Intracellular Organelle Dynamics

Boecker, C. A. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.167998 · Cited by 24 · see citing works

High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia

Ebrahimi‐Fakhari, D., Alecu, J. E., Brechmann, B., ZIEGLER, M. L., Eberhardt, K., Jumo, H., D’Amore, A., Habibzadeh, P., Faghihi, M. A., Bleecker, J. D., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab221 · Cited by 22 · see citing works

Keeping synapses in shape: degradation pathways in the healthy and aging brain

Kuijpers, M. (2022) · Neuronal Signaling · doi:10.1042/ns20210063 · Cited by 22 · see citing works

Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders

Lu, J., Florio, D. N. D., Boya, P., Maday, S., Springer, W., & Chu, C. T. (2025) · Autophagy · doi:10.1080/15548627.2025.2581217 · Cited by 21 · see citing works

RUSC2 and WDR47 oppositely regulate kinesin–1-dependent distribution of ATG9A to the cell periphery

Guardia, C. M. A., Jain, A., Mattera, R., Friefeld, A., Li, Y., & Bonifacino, J. S. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-06-0295 · Cited by 21 · see citing works

The autophagy protein ATG-9 regulates lysosome function and integrity.

Peng, K., Zhao, G., Zhao, H.-Y., Noda, N., & Zhang, H. (2025) · Journal of Cell Biology · doi:10.1083/jcb.202411092 · Cited by 17 · see citing works

Autophagy is Required for Remodeling in Postnatal Developing Ribbon Synapses of Cochlear Inner Hair Cells

Xiong, W., Wei, W., Qi, Y., Du, Z., Qu, T., Liu, K., & Gong, S. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.032 · Cited by 20 · see citing works

Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans

Alexander-Floyd, J., Haroon, S., Ying, M., Entezari, A. A., Jaeger, C., Vermulst, M., & Gidalevitz, T. (2020) · BMC Biology · doi:10.1186/s12915-020-0750-5 · Cited by 19 · see citing works

Retrograde Transport and ATG-4.2-Mediated Maturation Cooperate to Remove Autophagosomes from the SynapsePreprint

Kargbo-Hill, S. E., & Colón‐Ramos, D. A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/287144

Different forms of autophagy restrict neurite outgrowth in disparate compartments in a single neuronPreprint

Mukherjee, S., Cuentas-Condori, A., Colón‐Ramos, D. A., & Stavoe, A. K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.24.746867

Autophagy in axonal and presynaptic development

Crawley, O., & Grill, B. J. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.03.011 · Cited by 17 · see citing works

Autophagy in synapse formation and brain wiring

Hassan, B. A., & Hiesinger, P. R. (2023) · Autophagy · doi:10.1080/15548627.2023.2179778 · Cited by 10 · see citing works

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

Yang, S., Park, D., Manning, L., Kargbo-Hill, S. E., Cao, M., Zhao, X., Gonzalez, I. J., Dong, Y., Clark, B., Shao, L., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.031 · Cited by 103 · see citing works