Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 60Effects of Radiation ExposureAntioxidant Activity and Oxidative StressMedicinal Plant Research

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Spinacia oleracea L. protects against gamma radiations: a study on glutathione and lipid peroxidation in mouse liver

Bhatia, A.L., Jain, M.·2004·Phytomedicine
DOI 10.1016/j.phymed.2003.07.004
Open this paper in CoChat — free account

Abstract

The present study deals with the protective effect of Spinacia oleracea L. against radiation-induced oxidative stress, which is evaluated in terms of lipid peroxidation (LPO) product and tissue levels of glutathione. Swiss albino male mice aged 6-8 weeks, weighing 22+/-3 g, each were selected from an inbred colony and divided into four groups. One group served as normal and a second group (extract of S. oleracea L. (SE) treated un-irradiated) were administered methanolic (50%) SE at a dose of 1100mg/kg body wt./day dissolved in distilled water. A third group (untreated-irradiated) was administered distilled water orally, which served as control. A fourth group (SE pre-treated irradiated) was administered methanolic (50%) SE at a dose of 1100 mg/kg body wt./day dissolved in distilled water. Two groups, one untreated-irradiated and another S. oleracea pre-treated irradiated were exposed to 5 Gy of gamma radiation at a rate of 1.07 Gy/min with a source-to-surface distance of 77.5 cm. The animals were autopsied at 1, 3, 7, 15, and 30 days post-exposure. LPO increased after irradiation up to day 15 in the untreated-irradiated group and up to day 7 in SE pre-treated irradiated mice. LPO values were significantly lower in the SE pre-treated irradiated group as compared to their respective untreated-irradiated group at all intervals, which reached normal values from day 7 onward. The percentage of protection observed in the SE pre-treated irradiated group was, 22.22%, 24.8%, 33.25%, 42.84% and 26.36% at 1, 3, 7, 15, 30 days post-exposure, respectively. Radiation-induced glutathione depletion was checked after 7 days' exposure in SE pre-treated irradiated as compared to untreated-irradiated in which recovery started after day 15. Values were significantly higher in the SE pre-treated irradiated group from their respective untreated-irradiated group at all intervals. The percentage of protection observed in the SE pre-treated irradiated group was, 29.41%, 42.68%, 43.55%, 53.81%, 39.28% at 1, 3, 7, 15, 30 days post-exposure, respectively. It is found that radiation-induced augmentation in malondialdehyde contents and depletion in glutathione changes in liver can be altered by S. oleracea L. The protection may be attributed to the combined effects of its constituents rather than to any single factor as the leaves are rich in carotenoid content (beta-carotene, lutein, Zeaxanthine), ascorbic acid, flavonoids and p-coumaric acid. Thus Spinacia, showing protection in liver, may prove promising as a rich source of antioxidants because its use is cost-effective, especially for peoples in adverse and hazardous circumstances who are living in poverty.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.phymed.2003.07.004

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 4

  1. Bhatia, 2000, Role of β-carotene against radiation induced lipid-peroxidation in mice testes, Res. J. Chem. Environ, 4, 59
  2. Blot, 1995, The initial trials, Am. J. Clin. Nutr, 62, 45
  3. Chandha, 1996, Natural sources of antioxidants and their adequacy in diet to prevent atherosclerosis, Mediquest, 143, 337
  4. Halliwell, B., Gutteridge, J.M.C., 1989. Production of hydroxyl radicals in living systems In: Free Radicals Biology and Medicine. Clarendon Press, Oxford, p. 31.

Cited by

See all 60

Metadata

Authors
Bhatia, A. L., & Jain, M.
Affiliations
University of Rajasthan (IN)
Corresponding author
Bhatia, A.L.
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2004-11
Volume
11
Issue
7-8
Pages
607-615
ISSN
0944-7113 (ISSN-L)
DOI
10.1016/j.phymed.2003.07.004
OpenAlex
W2041559070
Cited by
60
References
46
Citations by year
2024: 3 · 2023: 1 · 2022: 5 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 10 · 2012: 2
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Phytomedicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
spinach, spinach extract, gamma radiation, radiation protection, oxidative stress, lipid peroxidation, glutathione, liver, antioxidant activity, radiation damage, pretreatment
MeSH terms
Animals, Gamma Rays, Glutathione, Liver, Male, Mice, Inbred Strains, Plant Extracts, Radiation-Protective Agents, Lipid Peroxidation, Oxidative Stress, Spinacia oleracea, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.