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Cited by 111Medicinal Plants and Bioactive CompoundsHeat shock proteins researchExercise and Physiological Responses

The DOI matches its Crossref record; 31 of the 33 references it cites were found in a registry or an index.

Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones

Panossian, Alexander, Wikman, Georg, Kaur, Punit, Asea, Alexzander·2009·Phytomedicine
DOI 10.1016/j.phymed.2008.12.003
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Abstract

Adaptogens are medicinal plants that augment resistance to stress, and increase concentration, performance and endurance during fatigue. Experiments were carried out with BALB/c mice taking ADAPT-232 forte, a fixed combination of three genuine (native) extracts of Eleutherococcus senticocus, Schisandra chinensis and Rhodiola rosea, characterised for the content of active markers eleutherosides, schisandrins, salidroside, tyrosol and rosavin and in doses of about 30, 90 and 180 mg/kg for seven consecutive days followed by forced swimming test to exhaustion. ADAPT-232 forte strongly augments endurance of mice, increasing the time taken to exhaustion (TTE) in a dose-dependent manner from 3.0+/-0.5 to 21.1+/-1.7 min, approximately seven fold. Serum Hsp72 was measured by EIA both in normal and stressful conditions before and after swimming test. Repeated administration of adaptogen dose dependently increases basal level of Hsp72 in serum of mice from 0.8-1.5 to 5.5-6.3 pg/ml. This effect is even stronger than the effect of stress, including both physical (swimming) and emotional impacts: 3.2+/-1.2 pg/ml. Cumulative effect of stress and adaptogen was clearly observed in groups of animals treated with adaptogen after swimming to exhaustion, when serum Hsp72 increased to 15.1+/-1 pg/ml and remained at almost the same level during the 7 days. It can be concluded that adaptogens induce increase of serum Hsp72, regarded as a defense response to stress, and increase tolerance to stress (in our model combination of physical and emotional stresses). It can be suggested that increased tolerance to stress induced by adaptogen is associated with its stimulation of expression of Hsp70 and particularly with Hsp72 production and release into systemic circulation, which is known as a mediator of stress response involved in reparation of proteins during physical load. Our studies suggest that this could be one of the mechanisms of action of plant adaptogens.

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Research works printed but not linked: 6

  1. Asea, 2007, Release of heat shock proteins: passive vs active release mechanisms, vol. 1, 3
  2. Asea, 2007, vol. 1
  3. International Conference on Harmonisation, 1996. ICH topic Q2B validation of analytical procedures: methodology, step 4, consensus guidelines. 6 November, 1996. 〈www.emea.eu.int/pdfs/human/ich/028195en.pdf〉.
  4. Johnson, 2005, Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function, Int. J. Hyperthermia, 21, 457, 10.1080/02656730500088211 · DOI
  5. Panossian, 2005, Effect of adaptogens on the central nervous system, Arq. Bras. Fitomed Cient., 2, 108
  6. Wiegant, 2008, Plant adaptogens activate cellular adaptive mechanisms by causing mild damage, vol. 5, 319

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Metadata

Authors
Panossian, A., Wikman, G., Kaur, P., & Asea, A.
Affiliations
  • Svenska Örtmedicinska Institute (SE)
  • Texas A&M Health Science Center (US)
Corresponding author
Panossian, Alexander
ORCID
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2009-06
Volume
16
Issue
6-7
Pages
617-622
ISSN
0944-7113 (ISSN-L)
DOI
10.1016/j.phymed.2008.12.003
OpenAlex
W2091170955
Cited by
111
References
33
Citations by year
2026: 7 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 8
FWCI
3.08
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Phytomedicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
adaptogens, stress tolerance, heat shock proteins, HSP72, HSP70, molecular chaperones, Schisandra chinensis, Rhodiola rosea, forced swim test, time to exhaustion, fatigue, emotional stress
MeSH terms
Animals, Enzyme-Linked Immunosorbent Assay, Female, Mice, Inbred BALB C, Physical Endurance, Plant Extracts, Plants, Medicinal, Molecular Chaperones, HSP70 Heat-Shock Proteins, Mice

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