Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile
Open accessAbstract
Since anti-angiogenic therapy has becoming a promising approach in the prevention of cancer and related diseases, the present study was aimed to examine the anti-angiogenic effect of siphonaxanthin from green alga (Codium fragile) in cell culture model systems and ex vivo approaches using human umbilical vein endothelial cells (HUVECs) and rat aortic ring, respectively. Siphonaxanthin significantly suppressed HUVEC proliferation (p<0.05) at the concentration of 2.5 μM (50% as compared with control) and above, while the effect on chemotaxis was not significant. Siphonaxanthin exhibited strong inhibitory effect on HUVEC tube formation. It suppressed the formation of tube length by 44% at the concentration of 10 μM, while no tube formation was observed at 25 μM, suggesting that it could be due to the suppression of angiogenic mediators. The ex vivo angiogenesis assay exhibited reduced microvessel outgrowth in a dose dependent manner and the reduction was significant at more than 2.5 μM. Our results imply a new insight on the novel function of siphonaxanthin in preventing angiogenesis related diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some species of algae produce siphonaxanthin, which possesses antiangiogenic activity.
“Some species of algae produce siphonaxanthin, which also possess antiangiogenic activity [234].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [234]
The citation lists haven’t been fetched yet
References 47 · Cited by 112
- Authors
- Ganesan, P., Matsubara, K., Ohkubo, T., Tanaka, Y., Noda, K., Sugawara, T., & Hirata, T.
- Affiliations
- Hiroshima University (JP)
- NOF Corporation (Japan) (JP)
- Kyoto University (JP)
- Corresponding author
- Sugawara, Tatsuya
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 17
- Issue
- 14
- Pages
- 1140-1144
- ISSN
- 0944-7113 (ISSN-L)
- OpenAlex
- W2023216040
- Cited by
- 112
- References
- 47
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 12 · 2021: 10 · 2020: 12 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 9
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- Locations
- Phytomedicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Keywords
- siphonaxanthin, Codium fragile, green algae, antiangiogenic activity, angiogenesis inhibition, human umbilical vein endothelial cells, endothelial cell proliferation, tube formation, aortic rings, chemotaxis, carotenoids
- MeSH terms
- Chlorophyta, Animals, Aorta, Dose-Response Relationship, Drug, Endothelium, Vascular, Humans, Plant Extracts, Umbilical Veins, Angiogenesis Inhibitors, Xanthophylls, Endothelial Cells, Cell Proliferation, Rats, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
