Cited by 394Ferroptosis and cancer prognosisCell death mechanisms and regulationIron Metabolism and Disorders

The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

Ooko, Edna, Saeed, Mohamed E.M., Kadioglu, Onat, Sarvi, Shabnam, Colak, Merve, Elmasaoudi, Kaoutar, Janah, Rabab, Greten, Henry J., Efferth, Thomas·2015·Phytomedicine

DOI 10.1016/j.phymed.2015.08.002

Open this paper in CoChat — free account

Abstract

Background Apoptosis and other forms of cell death have been intensively investigated in the past years to explain the mode of action of synthetic anticancer drugs and natural products. Recently, a new form of cell death emerged, which was termed ferroptosis, because it depends on intracellular iron. Here, the role of genes involved in iron metabolism and homeostasis for the cytotoxicity of ten artemisinin derivatives have been systematically investigated.Material and methods Log10IC50 values of 10 artemisinin derivatives (artesunate, artemether, arteether, artenimol, artemisitene, arteanuin B, another monomeric artemisinin derivative and three artemisinin dimer molecules) were correlated to the microarray-based mRNA expression of 30 iron-related genes in 60 cell lines of the National Cancer Institute (NCI, USA) as determined in 218 different microarray hybridization experiments. The effect of desferoxamine and ferrostatin-1 on the cytotoxicity of artenimol of CCRF-CEM cells was determined by resazurin assays. The mRNA expression of TFRC was exemplarily validated by immunohistochemical detection of transferrin receptor protein expression.Results The mRNA expression of 20 genes represented by 59 different cDNA clones significantly correlated to the log10IC50 values for the artemisinins, including genes encoding transferrin (TF), transferrin receptors 1 and 2 (TFRC, TFR2), cerulopasmin (CP), lactoferrin (LTF) and others. The ferroptosis inhibitor ferrostatin-1 and the iron chelator deferoxamine led to a significantly reduced cytotoxicity of artenimol, indicating ferroptosis as cell death mode.Conclusion The numerous iron-related genes, whose expression correlated with the response to artemisinin derivatives speak in factor for the relevance of iron for the cytotoxic activity of these compounds. Treatment with ferroptosis-inducing agents such as artemisinin derivatives represents an attractive strategy for cancer therapy. Pre-therapeutic determination of iron-related genes may indicate tumor sensitivity to artemisinins. Ferroptosis induced by artemisinin-type drugs deserve further investigation for individualized tumor therapy.

Integrity signals

Registry

Crossref · 10.1016/j.phymed.2015.08.002

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
Monks, A. P., Scudiero, D. A., Skehan, P., Shoemaker, R. H., Paull, K. D., Vistica, D. T., Hose, C. D., Langley, J. W., Cronise, P., Vaigro-Wolff, A., et al. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.11.757 · Cited by 3,305
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Alley, M. C., Scudiero, D. A., Monks, A. P., Hursey, M. L., Czerwiński, M., Fine, D. L., Abbott, B. J., Mayo, J. G., Shoemaker, R. H., & Boyd, M. R. (1988) · PubMed · Cited by 3,082
The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
A gene expression database for the molecular pharmacology of cancer
Scherf, U., Ross, D. T., Waltham, M. C., Smith, L. H., Lee, J. K., Tanabe, L. K., Kohn, K. W., Reinhold, W. C., Myers, T. G., Andrews, D. T., et al. (2000) · Nature Genetics · doi:10.1038/73439 · Cited by 1,450
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
Tu, Y. (2011) · Nature Medicine · doi:10.1038/nm.2471 · Cited by 1,397
Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146
CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
Reinhold, W. C., Sunshine, M., Liu, H., Varma, S., Kohn, K. W., Morris, J., Doroshow, J., & Pommier, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1370 · Cited by 887
Apoptosis and cancer: the genesis of a research field
Cotter, T. G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2663 · Cited by 783

Flagged first, then by citations

Show all 54 references

1 of the 54 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Krishna, 2014, A randomized, double-blind, placebo-controlled pilot study of oral artesunate therapy for colorectal cancer, EBioMedicine, 2014, 1
Whitney, 1995, Transferrin receptor expression in nonsmall cell lung cancer, Histopathol. Clin. Correl. Cancer, 76, 20

Sorted by citations

Items 201–300 of 394

Erastin enhances metastatic potential of ferroptosis-resistant ovarian cancer cells by M2 polarization through STAT3/IL-8 axis
Cang, W., Wu, A., Gu, L., Wang, W., Tian, Q., Zheng, Z., & Qiu, L. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109422 · Cited by 28
Tailored theranostic nanoparticles cause efficient ferroptosis in head and neck squamous cell carcinoma through a reactive oxygen species “butterfly effect”
Zhang, X., Yang, S., Wang, Q., Ye, W., Liu, S., Wang, X., Zhang, Z., Cao, L., & Jiang, X. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130083 · Cited by 28
Ferroptosis: A New Strategy for Cancer Therapy
Chen, Y., Fan, Z., Hu, S., Lu, C., Xiang, Y., & Liao, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.830561 · Cited by 27
Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin
Li, S., Xu, W., Wang, H., Tang, T., Ma, J., Cui, Z., Shi, H., Qin, T., Zhou, H., Li, L., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112742 · Cited by 26
Natural biomolecules and derivatives as anticancer immunomodulatory agents
Bernitsa, S., Dayan, R., Stephanou, A., Tzvetanova, I. D., & Patrikios, I. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1070367 · Cited by 29
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition
Lei, Y., Yf, W., Xiao, J., Shen, Q., Chi, S., Gao, Y., Lin, D., Ding, J., Fang, Y.-F., & Chen, Y. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01097-4 · Cited by 26
Therapeutic Potentials and Mechanisms of Artemisinin and its Derivatives for Tumorigenesis and Metastasis
Li, Y., Zhou, X., Liu, J., Yuan, X., & He, Q. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200120100252 · Cited by 26
A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species
Chen, Z., Kang, X., Wu, Y., Xiao, H., Cai, X., Sheng, S., Wang, X., & Chen, S. (2019) · Chemical Communications · doi:10.1039/c9cc00531e · Cited by 25
Synthesis of artemisinin-piperazine-furan ether hybrids and evaluation of in vitro cytotoxic activity
Wei, M., Yu, J., Liu, X., Li, X., Zhang, M., Yang, P., & Yang, J. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113295 · Cited by 25
Mechanistic elucidation of ferroptosis and ferritinophagy: implications for advancing our understanding of arthritis
Guo, C., Peng, J., Cheng, P., Yang, C., Gong, S., Zhang, L., Zhang, T., & Peng, J. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1290234 · Cited by 25
Construction and Validation of a Ferroptosis-Related Prognostic Signature for Melanoma Based on Single-Cell RNA Sequencing
Liu, Y., Shou, Y., Zhu, R., Qiu, Z., Zhang, Q., & Xu, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.818457 · Cited by 24
An endoplasmic reticulum-targeting hydroxyl radical fluorescent probe for imaging of ferroptosis and screening of natural protectants
Li, H., Luo, X., Jian, Y., Lv, J., Li, X., Gao, J., Shi, W. S., Li, X., Yuan, Z., & Ma, H. (2025) · Chemical Science · doi:10.1039/d4sc07953a · Cited by 23
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches
Wang, J., Guo, D., Jiang, S., Wu, W., & Gao, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00416-5 · Cited by 27
Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate
Tsuda, K., Miyamoto, L., Hamano, S., Morimoto, Y., Kangawa, Y., Fukue, C., Kagawa, Y., Horinouchi, Y., Xu, W., Ikeda, Y., et al. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00855 · Cited by 23
Artesunate-loaded poly (lactic-co-glycolic acid)/polydopamine-manganese oxides nanoparticles as an oxidase mimic for tumor chemo-catalytic therapy
Xi, J., Huang, Y., Chen, J., Zhang, J., Gao, L., Fan, L., & Qian, X. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.03.124 · Cited by 22
Ubiquitin‐specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6
Lian, F., Dong, D., Pu, J., Yang, G., Yang, J., Yang, S., Wang, Y., Zhao, B., & Lu, M. (2023) · Environmental Toxicology · doi:10.1002/tox.23992 · Cited by 21
The plasma exosomes from patients with primary Sjögren’s syndrome contain epithelial cell–derived proteins involved in ferroptosis
Peng, X., Hou, L., Wu, X. F., Liu, Z., Wang, Y., Zeng, P., Yang, Y., Ma, W., & Yang, P. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02361-0 · Cited by 22
Redox-Regulated Iron Metabolism and Ferroptosis in Ovarian Cancer: Molecular Insights and Therapeutic Opportunities
Liu, D., Hu, Z., Lu, J., & Yi, C. (2024) · Antioxidants · doi:10.3390/antiox13070791 · Cited by 22
Artemether suppresses cell proliferation and induces apoptosis in diffuse large B cell lymphoma cells
Zhao, X., Guo, X., Yue, W., Wang, J., Yang, J., & Chen, J. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5063 · Cited by 20
Research Progress in Regulation of Ferroptosis by Epigallocatechin-3- gallate in Tumor Cells
Li, Y., Zhang, L., & dong, R. (2022) · Letters in Drug Design & Discovery · doi:10.2174/1570180819666220819150351 · Cited by 19
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway
Li, J., Feng, L., Yuan, Y., He, T., Zou, X., Su, B., Liu, K., & Yang, X. (2024) · World Journal of Surgical Oncology · doi:10.1186/s12957-024-03544-w · Cited by 19
Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities
Tranchese, R. V., Battista, S., Cerchia, L., & Fedele, M. (2024) · Biomolecules · doi:10.3390/biom14111443 · Cited by 20
Organism-like formation of Schistosoma hemozoin and its function suggest a mechanism for anti-malarial action of artemisinin
Sun, J., Li, C., & Wang, S. (2016) · Scientific Reports · doi:10.1038/srep34463 · Cited by 18
pH-dependent rearrangement determines the iron-activation and antitumor activity of artemisinins
Bai, G., Gao, Y., Liu, S., Shui, S., & Liu, G. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.024 · Cited by 19
Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells
Koike, T., Takenaka, M., Suzuki, N., Ueda, Y., Mori, M., Hirayama, T., Nagasawa, H., & Morishige, K. (2022) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-82 · Cited by 18
Diverse Sesquiterpenoids from the Roots of Croton crassifolius and Their Inhibitory Effects on Ferroptosis
Yang, F., Jiang, X., Cao, L., Gu, Q., Teng, X., & He, L. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202101028 · Cited by 18
Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation
Kadioglu, O., Klauck, S. M., Fleischer, E., Shan, L., & Efferth, T. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03058-4 · Cited by 18
Self-citation
The Regulation Role of Ferroptosis Mechanism of Anti-Cancer Drugs and Noncoding RNAs
Ensoy, M., Bumin, Z. S., Jama, H. A., & Cansaran‐Duman, D. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629154418 · Cited by 17
Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment
Yang, J., & Gu, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1283465 · Cited by 19
Dihydroartemisinin eliminates senescent cells by promoting autophagy‐dependent ferroptosis via AMPK/mTOR signaling pathway
Wan, X., Li, C., Tan, Y. H., Zuo, S., Deng, F. M., Sun, J. F., & Liu, Y. L. (2024) · Cell Biology International · doi:10.1002/cbin.12143 · Cited by 18
Low Doses of Silver Nanoparticles Selectively Induce Lipid Peroxidation and Proteotoxic Stress in Mesenchymal Subtypes of Triple-Negative Breast Cancer
Snyder, C. M., Rohde, M. M., Fahrenholtz, C. D., Swanner, J. L., Sloop, J. T., Donati, G. L., Furdui, C. M., & Singh, R. N. (2021) · Cancers · doi:10.3390/cancers13164217 · Cited by 18
Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates
Yang, F., Sun, S., Wang, S., Guo, J., Liu, X., Ge, N., & Wang, G. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i1.1 · Cited by 18
The mechanism and progress of ferroptosis in pancreatic cancer
Bao, Z., Hou, X.-B., Li, H.-L., Mao, Y., & Wang, W. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151919 · Cited by 17
Mechanism of ferroptosis resistance in cancer cells
Wang, Y., Yu, G., & Chen, X. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2024.127 · Cited by 18
Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy
Zheng, D., Chen, S., Cai, K., Lei, L., Wu, C., Sun, C., Deng, Y., & Chao, Y. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02355-3 · Cited by 16
Amplification of ferroptosis with a liposomal nanoreactor cooperates with low-toxicity doxorubicin apoptosis for enhanced tumor chemotherapy
Ji, P., Wang, X., Yin, J., Yao, Y., & Du, W. (2022) · Biomaterials Science · doi:10.1039/d2bm00079b · Cited by 15
Systematic evaluation of tumor microenvironment and construction of a machine learning model to predict prognosis and immunotherapy efficacy in triple-negative breast cancer based on data mining and sequencing validation
Gou, Q., Liu, Z., Xie, Y., Deng, Y., Ma, J., Li, J., & Zheng, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995555 · Cited by 15
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids
Chen, D., Li, G., Luo, L., Liu, K., Chu, X., Liu, K., Lai, T., Liao, Y., Lin, X., & Chen, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156155 · Cited by 15
Insights into the pathogenesis of gestational and hepatic diseases: the impact of ferroptosis
You, Y., Qian, Z., Jiang, Y., Chen, L., Wu, D., Liu, L., Zhang, F., Ning, X., Zhang, Y., & Xiao, J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1482838 · Cited by 18
Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins
Bonepally, K. R., Takahashi, N., Matsuoka, N., Koi, H., Mizoguchi, H., Hiruma, T., Ochiai, K., Suzuki, S., Yamagishi, Y., Oikawa, H., et al. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c01017 · Cited by 15
Expression of transferrin receptor‐1 (TFR‐1) in canine osteosarcomas
Vico, G. D., Martano, M., Maiolino, P., Carella, F., & Leonardi, L. (2020) · Veterinary Medicine and Science · doi:10.1002/vms3.258 · Cited by 15
Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma
Yu, Y., Ren, Y., Wang, C., Li, Z., Niu, F., Li, Z., Ye, Q., Wang, J., Yuan, Y., Liu, P., et al. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022166 · Cited by 14
A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities
Koi, H., Takahashi, N., Fuchi, Y., Umeno, T., Muramatsu, Y., Seimiya, H., Karasawa, S., & Oguri, H. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob00919a · Cited by 14
Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway
Xu, L., Zhang, M., Pan, J., Xu, X., Zhang, Y., Han, X., Yin, L., Chen, L., Ren, J., Yu, J., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1135366 · Cited by 13
Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway
Zhang, J., Xiao, Y., Li, Y., Zhu, Y., Li, Y., Zhao, R.-S., Jin, N., Fang, J., Li, X., & Han, J. (2023) · Integrative Cancer Therapies · doi:10.1177/15347354231210867 · Cited by 15
Liensinine diperchlorate and artemisitene synergistically attenuate breast cancer progression through suppressing PI3K-AKT signaling and their efficiency in breast cancer patient-derived organoids
Lin, X., Lin, T., Liu, M., Chen, D., & Chen, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116871 · Cited by 13
Heteronemin promotes iron-dependent cell death in pancreatic cancer
Kaftan, G., Erdoğan, M. A., El‐Shazly, M., Lu, M., Shih, S., Lin, H., Saso, L., & Armağan, G. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02736-7 · Cited by 13
Ferritinophagy: A new idea for liver diseases regulated by ferroptosis
Qian, Z., Li, J., Xiong, W., & Mao, X. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.10.005 · Cited by 13
Potential therapies for HCC involving targeting the ferroptosis pathway
Li, D. (2024) · American Journal of Cancer Research · doi:10.62347/sigp9279 · Cited by 16
Natural products targeting ferroptosis pathways in cancer therapy (Review)
Na, X., Li, L., Liu, D., He, J., Zhang, L., & Zhou, Y. (2024) · Oncology Reports · doi:10.3892/or.2024.8782 · Cited by 15
The Real Cytotoxic Effect of Artemisinins on Colon Cancer Cells in a Physiological Cell Culture Setting. How Composition of the Culture Medium Biases Experimental Findings
Otto‐Ślusarczyk, D., Mielczarek‐Puta, M., & Graboń, W. (2021) · Pharmaceuticals · doi:10.3390/ph14100976 · Cited by 12
Synergistic Inhibition of Delayed Rectifier K+ and Voltage-Gated Na+ Currents by Artemisinin in Pituitary Tumor (GH3) Cells
So, E. C., Wu, S., Wu, P., Chen, H., & Yang, C.-J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000475436 · Cited by 12
A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy
Fischer, N., Seo, E., Abdelfatah, S., Fleischer, E., Klinger, A., & Efferth, T. (2021) · Investigational New Drugs · doi:10.1007/s10637-020-01042-w · Cited by 12
Self-citation
Effectiveness of artesunate combined with fractional CO2 laser in a hypertrophic scar model with underlying mechanism
Zhang, J., Zhou, S., Xia, Z., Peng, Z., Luo, W., Cheng, X., & Yang, R. (2021) · Burns · doi:10.1016/j.burns.2021.05.013 · Cited by 12
Crosstalk between ferroptosis and steroid hormone signaling in gynecologic cancers
Lai, W., Chen, J., Wang, T., & Liu, Q. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1223493 · Cited by 12
Advancements in the therapeutic potential of sesquiterpenoids for the treatment of hepatocellular carcinoma (Review)
Li, Y., Du, X., & Mao, J. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5766 · Cited by 11
Identification of ferroptosis-related molecular subtypes and a methylation-related ferroptosis gene prognostic signature in cervical squamous cell carcinoma
Yu, L., Gao, Z., Li, Z., Liu, P., Gao, Y., & Liang, G. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05267-z · Cited by 11
Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives
Amin, M. A., Zehravi, M., Sweilam, S. H., Jahnavi, P., Gupta, J. K., Rajashakar, V., Vodeti, R., Billah, A. A. M., Dharmamoorthy, G., Arjun, U. V. N. V., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70834 · Cited by 11
Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease—Brief Report
Tran, L. M., Xie, B., Assaf, E., Ferrari, R., Pipinos, I. I., Casale, G. P., Mota, R. I., Watkins, S. C., & Sachdev, U. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319518 · Cited by 9
Inhibition of keloid fibroblast proliferation by artesunate is mediated by targeting the IRE1α/XBP1 signaling pathway and decreasing TGF-β1
Han, X., Jiang, S., Hu, C., Wang, Y., Zhao, L., & Wang, W. (2024) · Burns · doi:10.1016/j.burns.2024.03.004 · Cited by 9
Targeting Ferroptosis: Small-molecule Inducers as Novel Anticancer Agents
Jin, S., Wang, H., Zhang, Z., & Yan, M. (2024) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206342278241008081126 · Cited by 9
The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis
Ke, A., Yang, W., Zhang, W., Chen, Y., Meng, X., Liu, J., & Dai, D. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156804 · Cited by 9
Artemisinin derivatives differently affect cell death of lung cancer subtypes by regulating GPX4 in patient-derived tissue cultures
Mölleken, J., Kragl, A., Monecke, A., Metelmann, I., Krämer, S., & Kallendrusch, S. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02537-2 · Cited by 13
An Artemisinin‐Derivative–(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity
Zhang, C., Fortin, P., Barnoin, G., Qin, X., Wang, X., Álvarez, Á. F., Bijani, C., Maddelein, M., Hemmert, C., Cuvillier, O., et al. (2020) · Angewandte Chemie · doi:10.1002/ange.202002992 · Cited by 9
Effect of Artesunate Combined With Fractional CO2 Laser on the Hypertrophic Scar in a Rabbit Model
Zhang, J., Xia, Z., Zhou, S., Luo, W., Peng, Z., & Yang, R. (2021) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23384 · Cited by 9
Oral delivery of ferroptosis inducers for effective treatment of hepatic fibrosis
Yu, Y., Zhang, S., Xu, Y., Shao, H., & Luo, L. (2024) · Nano Research · doi:10.1007/s12274-024-6725-z · Cited by 9
Repurposing Artemisinin-Based Drugs from Antimalarial to Pan-Therapeutic: Pharmacological Promise and Therapeutic Challenges
Wu, D., Zeng, H., Tan, J., Xu, Q., Khan, F. A., Pandupuspitasari, N. S., Yang, S., & Huang, C. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s545163 · Cited by 9
ARTEMISIA ANNUA L. EXTRACT: A NEW PHYTOPRODUCT WITH SOD-LIKE AND ANTITUMOUR ACTIVITY
Lucaciu, R. L. (2020) · FARMACIA · doi:10.31925/farmacia.2020.5.6 · Cited by 8
The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment
Lyu, H., Kong, J., Chen, J., Zhang, R., Xiao, S., Guo, D. S., Zhang, Q., Chen, X., Tang, J., & Zhou, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413334 · Cited by 12
Artesunate Decreases β-Catenin Expression, Cell Proliferation and Apoptosis Resistance in the MG-63 Human Osteosarcoma Cell Line
Chen, P., Gu, W.-L., Gong, M., Wang, J., & Li, D.-Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484118 · Cited by 8
Retracted
The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells
Elbadawi, M., Boulos, J. C., Dawood, M., Zhou, M., Gul, W., ElSohly, M. A., Klauck, S. M., & Efferth, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041107 · Cited by 8
Self-citation
Artemisitene: a promising natural drug candidate with various biological activities needs to confirm the interactional targets
Lin, X., & Chen, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1221291 · Cited by 8
Research progress on the use of traditional Chinese medicine to treat diseases by regulating ferroptosis
Liu, S., Yang, X., Zheng, S., Chen, C., Qi, L., Xiangdong, X., & Zhang, D. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101451 · Cited by 7
Can the iron content of culture media impact on the leishmanicidal effect of artemisinin?
Dighal, A., Sarkar, S. D., Gille, L., & Chatterjee, M. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1939325 · Cited by 7
Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis
Chuang, Y.-T., Yen, C., Chien, T., Chang, F., Tsai, Y., Wu, K., Tang, J., & Chang, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116083 · Cited by 10
Dihydroartemisinin regulates the apoptosis and growth of colorectal cancer by suppressing DPYSL2 and increasing TF and ACHE
Zhang, X., Cao, J., Liao, D., Xia, Z., Xiong, L., Wu, M., Wang, C., Yang, X., Qiu, Y., Zhang, L., et al. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104668 · Cited by 7
Matrine Can Inhibit the Growth of Colorectal Cancer Cells by Inducing Ferroptosis
Wang, J., Tang, P., Cai, Q., Xie, S., Duan, X., & Pan, Y. (2020) · Natural Product Communications · doi:10.1177/1934578x20982779 · Cited by 7
Multiple Strikes Achieve Remarkable Tumor-Inhibition Efficiency via Multi-mechanism Combination
Yao, H., Qiao, P., Zhu, Z., Sun, F., Zhou, H., Geng, M., & Du, B. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00778 · Cited by 7
Zinc Protoporphyrin-9 Potentiates the Anticancer Activity of Dihydroartemisinin
Zhang, Y., Zhang, X., & Zhou, B. (2023) · Antioxidants · doi:10.3390/antiox12020250 · Cited by 7
The Therapeutic Effect of Natural Compounds on Osteoporosis through Ferroptosis
Zhang, Y., Qu, Z., Zhao, Y., Zhang, B., Gong, Y., Wang, X., Gao, X., Wang, D., & Yan, L. W. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673258420230919103405 · Cited by 9
Natural products and the balancing act of autophagy-dependent/independent ferroptosis in cancer therapy
Anaraki, S. R., Farzami, P., Nasab, S. S. H., Kousari, A., Naghibi, A. F., Zadeh, M. S., Barati, R., Taha, S. R., Karimian, A., Nabi‐Afjadi, M., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02782-1 · Cited by 7
Ferroptosis and its modulators: A raising target for cancer and Alzheimer’s disease
Singh, G., Kesharwani, P., Singh, G. K., Kumar, S., Putta, A., & Modi, G. P. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117564 · Cited by 7
The effect of sodium nitroprusside in scaffolds for synergetic gas‐photothermal therapy of osteosarcoma
Dong, S., Zhang, Y., Mei, Y., Sun, C., Yu, X., Gholipourmalekabadi, M., Lin, K., Niu, L., Zhao, L., & Yuan, C. (2025) · BMEMat · doi:10.1002/bmm2.70011 · Cited by 6
Natural products targeting ferroptosis in cancer: molecular mechanisms and applications
Ye, X., & Ju, X. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1588668 · Cited by 6
In Vitro Evaluation Reveals Effect and Mechanism of Artemether against Toxoplasma gondii
Xu, Q., Duan, Y., Pan, M., Jin, Q.-W., Tao, J., & Huang, S. (2023) · Metabolites · doi:10.3390/metabo13040476 · Cited by 6
A novel ferroptosis‑related gene signature for overall survival prediction and immune infiltration in patients with breast cancer
Zhang, Y., Liang, Y., Wang, Y., Ye, F., Kong, X., & Yang, Q. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5438 · Cited by 6
Prognostic Significance of Iron Metabolism Related Genes in Human Lung Adenocarcinoma
Li, P., Wu, X., Chen, P., & Gu, Z. (2023) · Cancer Management and Research · doi:10.2147/cmar.s398982 · Cited by 6
Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment
Shichiri, M., Suzuki, H., Isegawa, Y., & Tamai, H. (2022) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-61 · Cited by 6
Artesunate Inhibits Metastatic Potential in Cisplatin-Resistant Bladder Cancer Cells by Altering Integrins
Zhao, F., Vakhrusheva, O., Markowitsch, S. D., Slade, K. S., Brandt, M. P., Tsaur, I., Cinatl, J. J., Michaelis, M., Efferth, T., Blaheta, R. A., et al. (2025) · Cells · doi:10.3390/cells14080570 · Cited by 5
Self-citation
Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)
Mouawad, N., Jaafari, N. E., El‐Sibai, M., & Abi‐Habib, R. J. (2025) · Oncology Reports · doi:10.3892/or.2025.9029 · Cited by 7
Natural products as modulators of ferroptosis: Therapeutic implications and molecular mechanisms in disease treatment
Tong, W. N., Mu, X., Xu, H., & Yin, X. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110259 · Cited by 5
Ferroptosis regulators related scoring system by Gaussian finite mixture model to predict prognosis and immunotherapy efficacy in nasopharyngeal carcinoma
Liu, Z., He, J., & Hu, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.975190 · Cited by 5
Downregulation of ferroptosis-related Genes can regulate the invasion and migration of osteosarcoma cells
Ding, R., Liao, L., Chen, J., Zhang, J., Cai, S., Miao, X., Li, T., Zhao, J., Chen, Q., Cheng, X., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-02319-x · Cited by 7
Iron metabolism in prostate cancer
Koltai, T., Reshkin, S. J., Baltazar, F., & Fliegel, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90528-2.00011-4 · Cited by 5
Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems
Tan, Y., Dong, X., Zhuang, D., Cao, B., Jiang, H., He, Q., & Zhao, M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04694-3 · Cited by 5
Investigation of new ferrocenyl-artesunate derivatives as antiparasitics
Munnik, B. L., Kaschula, C. H., Harding, C. R., & Chellan, P. (2023) · Dalton Transactions · doi:10.1039/d3dt02254d · Cited by 5
Current understanding of phytochemicals from Chinese herbal medicines for ferroptosis-mediated cancer prevention and treatment
Hu, Y., Zhai, W., Chen, H., Li, L., Gao, W., Wei, Y., & Wu, J. (2022) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2022.100100 · Cited by 6
Artemisitene Ameliorates Diabetic Wounds by Inhibiting Ferroptosis Through Activation of the Nrf2/GPX4 Pathway
Honghao, X., Bu, Y., Yuan, Z., Zhengyang, L., Feiya, Z., Leyi, C., Weiyang, G., Anyuan, W., & Wu, H. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70952 · Cited by 4
Repurposing approved drugs as ferroptosis modulators: a critical review of clinical trials in cancer and neurodegeneration
Zayed, M., Massoud, A., Elwakeel, E., Ezzat, P., Alammar, Y., El-Wahab, N. A. A., Afifi, R. W., & Jeong, B. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05582-5 · Cited by 5
α-Solanine induces ferroptosis in nasopharyngeal carcinoma via targeting HSP90α/p53 axis
Cui, X., Gong, Y., Ge, J., Feng, X., Xiong, X., Shi, Z., Zheng, Q., Li, D., & Bi, S. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105517 · Cited by 5

Authors: Ooko, E., Saeed, M. E. M., Kadioglu, O., Sarvi, S., Colak, M., Elmasaoudi, K., Janah, R., Greten, H. J., & Efferth, T.
Affiliations: Johannes Gutenberg University Mainz (DE)
Universidade do Porto (PT)
Corresponding author: Efferth, Thomas
ORCID: Ooko, Edna
Saeed, Mohamed E.M.
Kadioglu, Onat
Greten, Henry J.
Efferth, Thomas
Venue: Phytomedicine
Publisher: Elsevier BV
Published: 2015-10
Volume: 22
Issue: 11
Pages: 1045-1054
ISSN: 0944-7113 (ISSN-L)
DOI: 10.1016/j.phymed.2015.08.002
OpenAlex: W1156477804
Cited by: 387
References: 54
Citations by year: 2026: 23 · 2025: 32 · 2024: 37 · 2023: 48 · 2022: 60 · 2021: 57 · 2020: 46 · 2019: 27 · 2018: 23 · 2017: 14 · 2016: 16 · 2015: 3
FWCI: 14.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Phytomedicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: artemisinin derivatives, ferroptosis, iron metabolism, ferrostatin-1, deferoxamine, transferrin receptor, ceruloplasmin, lactoferrin, tumor cell killing, anticancer natural products, CCRF-CEM cells, precision oncology
MeSH terms: Artesunate, Artemether, Cyclohexylamines, Deferoxamine, Humans, Iron, Phenylenediamines, Molecular Structure, Gene Expression Regulation, Neoplastic, Cell Death, Apoptosis, Inhibitory Concentration 50, Oligonucleotide Array Sequence Analysis, Artemisinins, Cell Line, Tumor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks