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Cited by 142Ovarian function and disordersCurcumin's Biomedical ApplicationsNatural Antidiabetic Agents Studies

The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.

Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

Heshmati, Javad, Moini, Ashraf, Sepidarkish, Mahdi, Morvaridzadeh, Mojgan, Salehi, Masoud, Palmowski, Andriko, Mojtahedi, Maryam Farid, Shidfar, Farzad·2021·Phytomedicine
DOI 10.1016/j.phymed.2020.153395
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Abstract

Background Curcumin is a biologically active phytochemical ingredient found in turmeric. It has several pharmacologic effects that might benefit patients with polycystic ovary syndrome (PCOS). Objective We hypothesized curcumin to be effective in improving blood sugar levels, insulin resistance and hyperandrogenism in individuals with PCOS. Methods In a randomized double-blind placebo-controlled trial, individuals with PCOS were treated with curcumin (500 mg three times daily) or placebo for 12 weeks. Primary outcome measures were fasting plasma glucose (FPG), fasting insulin (FI), sex hormone levels, and hirsutism (Ferriman-Gallwey [mFG] score). Secondary outcomes included anthropometric measurements. Results Of 72 randomized individuals, 67 completed the trial. The two groups were comparable at baseline. At the end of the study, FPG and Dehydroepiandrosterone levels had decreased significantly in the intervention group compared to control (difference of change (post-pre) between intervention and placebo groups: -4.11 mg/dL; 95% CI: -8.35, -0.35 mg/dL; p = 0.033 and -26.53 microg/dL; 95% CI: -47.99, -4.34 µg/dL; p = 0.035, respectively). We also observed a statistically non-significant increase (p = 0.082) in Estradiol levels in the intervention group compared to control. No serious adverse events were reported throughout the trial. Conclusions Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia. However, longer trials investigating different dosages in longer durations are needed to underpin these findings.

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  1. Julie, 2009, Anti-inflammatory properties of curcumin, a major constituent, Altern. Med. Rev., 14

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Metadata

Authors
Heshmati, J., Moini, A., Sepidarkish, M., Morvaridzadeh, M., Salehi, M., Palmowski, A., Mojtahedi, M. F., & Shidfar, F.
Affiliations
  • Iran University of Medical Sciences (IR)
  • Royan Institute (IR)
  • Babol University of Medical Sciences (IR)
  • Kermanshah University of Medical Sciences (IR)
  • Stiftung Charité (DE)
  • Roointan Arash Hospital (IR)
Corresponding author
Shidfar, Farzad
ORCID
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2021-01
Volume
80
Pages
153395
ISSN
0944-7113 (ISSN-L)
DOI
10.1016/j.phymed.2020.153395
OpenAlex
W3093833227
Cited by
142
References
47
Citations by year
2026: 19 · 2025: 35 · 2024: 27 · 2023: 27 · 2022: 14 · 2021: 20
FWCI
13.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Phytomedicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
curcumin, polycystic ovary syndrome, insulin resistance, hyperandrogenism, blood glucose, fasting insulin, dehydroepiandrosterone, estradiol, hirsutism, Ferriman-Gallwey score, dietary supplementation, phytochemicals
MeSH terms
Adolescent, Adult, Androgens, Blood Glucose, Curcumin, Dehydroepiandrosterone, Double-Blind Method, Female, Hirsutism, Humans, Hyperglycemia, Insulin, Insulin Resistance, Middle Aged, Placebos, Polycystic Ovary Syndrome, Treatment Outcome, Dietary Supplements, Young Adult

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