Cited by 100Curcumin's Biomedical ApplicationsOvarian function and disordersNatural Antidiabetic Agents Studies

The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial

Sohaei, Sara, Amani, Reza, Tarrahi, Mohammad Javad, Ghasemi-Tehrani, Hatav·2019·Complementary Therapies in Medicine

Abstract

Objective The aim of the current study was to assess the effects of curcumin supplementation on glycemic status, lipid profile and high sensitivity C-reactive protein (hs-CRP) serum levels in women with polycystic ovary syndrome (PCOS). Design This randomized double-blind placebo-controlled clinical trial was conducted on 60 women who were randomly assigned to the intervention or control groups using block randomization. Setting Infertility referral center. Interventions Curcumin (500 mg/d) or placebo twice daily for 6 weeks. Main outcome measures Serum evaluation of lipid profile (triglycerides (TG), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol concentrations, LDL/HDL-C and TG/HDL-C ratios), glycemic index (fasting blood sugar (FBS), insulin concentrations, homeostasis model of assessment insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)) and hs-CRP levels. Results Glycemic index, lipid profile and hs-CRP serum levels were measured at first and at the end of trial. Serum insulin (p = 0.020) and Quantitative Insulin Sensitivity Check Index (QUICKI) (p = 0.003) were improved significantly, while Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p = 0.067) improved marginally in curcumin treated group (within group analysis). Conclusions Curcumin supplementation might be beneficial for improving serum insulin and QUICKI, however, future investigations are suggested in order to draw a firm link between curcumin and glycemia control.

Integrity signals

Registry

Crossref · 10.1016/j.ctim.2019.102201

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 73 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Sohaei, S., Amani, R., Tarrahi, M. J., & Ghasemi-Tehrani, H.
Affiliations
Isfahan University of Medical Sciences (IR)
Corresponding author
Amani, Reza
Venue
Complementary Therapies in Medicine
Publisher
Elsevier BV
Published
2019-12
Volume
47
Pages
102201
ISSN
0965-2299 (ISSN-L)
OpenAlex
W2977196190
Cited by
100
References
73
Citations by year
2026: 6 · 2025: 12 · 2024: 17 · 2023: 25 · 2022: 14 · 2021: 23 · 2020: 3
FWCI
3.37
Type
journal article
Language
en
Open access
closed
Locations
  • Complementary Therapies in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Isfahan University of Medical Sciences
  • Vice-Chancellor for Research, Shiraz University of Medical Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
curcumin, polycystic ovary syndrome, overweight women, obesity, insulin resistance, glycemic control, lipid profile, C-reactive protein, QUICKI, HOMA-IR, serum insulin, triglycerides, LDL/HDL ratio
MeSH terms
Adult, C-Reactive Protein, Curcumin, Double-Blind Method, Female, Humans, Hyperinsulinism, Hyperlipidemias, Obesity, Polycystic Ovary Syndrome, Dietary Supplements, Overweight

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review