The effects of curcumin supplementation on glycemic status, lipid profile and hs-CRP levels in overweight/obese women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled clinical trial
Abstract
Objective The aim of the current study was to assess the effects of curcumin supplementation on glycemic status, lipid profile and high sensitivity C-reactive protein (hs-CRP) serum levels in women with polycystic ovary syndrome (PCOS). Design This randomized double-blind placebo-controlled clinical trial was conducted on 60 women who were randomly assigned to the intervention or control groups using block randomization. Setting Infertility referral center. Interventions Curcumin (500 mg/d) or placebo twice daily for 6 weeks. Main outcome measures Serum evaluation of lipid profile (triglycerides (TG), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol concentrations, LDL/HDL-C and TG/HDL-C ratios), glycemic index (fasting blood sugar (FBS), insulin concentrations, homeostasis model of assessment insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)) and hs-CRP levels. Results Glycemic index, lipid profile and hs-CRP serum levels were measured at first and at the end of trial. Serum insulin (p = 0.020) and Quantitative Insulin Sensitivity Check Index (QUICKI) (p = 0.003) were improved significantly, while Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p = 0.067) improved marginally in curcumin treated group (within group analysis). Conclusions Curcumin supplementation might be beneficial for improving serum insulin and QUICKI, however, future investigations are suggested in order to draw a firm link between curcumin and glycemia control.
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Another study of 51 women found that curcumin improved insulin sensitivity (QUICKI) after six weeks but did not significantly alter lipid or glycemic markers compared to placebo.
“Another study involving 51 women found that curcumin improved insulin sensitivity (QUICKI index) after six weeks of supplementation but did not significantly alter lipid or glycemic markers compared to placebo [203].”
Cites
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · see citing works
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715 · see citing works
Spear, B. A., Winick, M., Phillips, C., & Wilfley, D. E. (1975) · Cited by 2,495 · see citing works
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L. M., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,363 · see citing works
Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,884 · see citing works
March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I. W., Norman, R. J., & Davies, M. J. (2010) · Human Reproduction · doi:10.1093/humrep/dep399 · Cited by 1,799 · see citing works
Knochenhauer, E. S., Key, T. J., Kahsar-Miller, M., Waggoner, W., Boots, L. R., & Azziz, R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5090 · Cited by 1,568 · see citing works
Oxidative stress, insulin signaling, and diabetes
Rains, J., & Jain, S. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.006 · Cited by 1,445 · see citing works
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61345-2 · Cited by 1,360 · see citing works
Han, J. C., Lawlor, D. A., & Kimm, S. Y. S. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60171-7 · Cited by 1,318 · see citing works
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142 · see citing works
Knochenhauer, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3078 · Cited by 1,134 · see citing works
Lawrence, J., Douglas, P., & Gandy, J. (2016) · doi:10.1002/9781119163411.ch73 · Cited by 1,014 · see citing works
Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A. M., & Giugliano, D. (2002) · Circulation · doi:10.1161/hc0702.104279 · Cited by 994 · see citing works
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664 · see citing works
Curcumin Extract for Prevention of Type 2 Diabetes
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012) · Diabetes Care · doi:10.2337/dc12-0116 · Cited by 636 · see citing works
Treatment options for polycystic ovary syndrome
Badawy, A., & Elnashar (2011) · International Journal of Women s Health · doi:10.2147/ijwh.s11304 · Cited by 613 · see citing works
Barry, J. A., Azizia, M., & Hardiman, P. J. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu012 · Cited by 603 · see citing works
Endothelial Function Testing as a Biomarker of Vascular Disease
Verma, S., Buchanan, M. R., & Anderson, T. J. (2003) · Circulation · doi:10.1161/01.cir.0000089191.72957.ed · Cited by 565 · see citing works
Body Fat Distribution and Insulin Resistance in Healthy Asian Indians and Caucasians
Raji, A., Seely, E. W., Arky, R. A., & Simonson, D. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7992 · Cited by 541 · see citing works
Ghosh, S., Banerjee, S., & Sil, P. C. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.05.022 · Cited by 501 · see citing works
Genetic, hormonal and metabolic aspects of PCOS: an update
De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., & Petraglia, F. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0173-x · Cited by 484 · see citing works
Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial
Rahmani, S., Asgary, S., Askari, G., Keshvari, M., Hatamipour, M., Feizi, A., & Sahebkar, A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5659 · Cited by 462 · see citing works
Vasheghani‐Farahani, A., Tahmasbi, M., Asheri, H., Ashraf, H., Nedjat, S., & Kordi, R. (2011) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.34781 · Cited by 335 · see citing works
Seo, K., Choi, M., Jung, U. J., Kim, H., Yeo, J., Jeon, S.-M., & Lee, M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700184 · Cited by 313 · see citing works
Fenkçi, V., Fenkçi, S. M., Yılmazer, M., & Serteser, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00571-5 · Cited by 306 · see citing works
Pathophysiology and types of dyslipidemia in PCOS
Diamanti‐Kandarakis, E., Papavassiliou, A. G., Kandarakis, S., & Chrousos, G. P. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.07.004 · Cited by 301 · see citing works
The role of low-grade inflammation in the polycystic ovary syndrome
Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 300 · see citing works
Brookheart, R. T., Michel, C. I., & Schaffer, J. E. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.011 · Cited by 279 · see citing works
Mohammadi, A., Sahebkar, A., Iranshahi, M., Amini, M., Khojasteh, R., Ghayour‐Mobarhan, M., & Ferns, G. A. (2012) · Phytotherapy Research · doi:10.1002/ptr.4715 · Cited by 277 · see citing works
Na, L., Li, Y., Pan, H., Zhou, X., Sun, D., Meng, M., Li, X., & Sun, C. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200131 · Cited by 269 · see citing works
Shin, S., Ha, T., McGregor, R. A., & Choi, M. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100440 · Cited by 257 · see citing works
Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat–fed hamsters
Jang, E.-M., Choi, M., Jung, U. J., Kim, M., Kim, H.-J., Jeon, S.-M., Shin, S., Seong, C.-N., & Lee, M. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.014 · Cited by 251 · see citing works
Yang, Y., Su, Y., Yang, H., Lee, Y., Chou, J. I., & Ueng, K. (2014) · Phytotherapy Research · doi:10.1002/ptr.5197 · Cited by 200 · see citing works
Usharani, P., Mateen, A., Naidu, M. U. R., Raju, Y. S. N., & Chandra, N. (2008) · Drugs in R&D · doi:10.2165/00126839-200809040-00004 · Cited by 195 · see citing works
Molecular mechanisms of hypolipidemic effects of curcumin
Zingg, J.-M. A., Hasan, S. T., & Meydani, M. (2013) · BioFactors · doi:10.1002/biof.1072 · Cited by 161 · see citing works
Tabrizi, R., Vakili, S., Akbari, M., Mirhosseini, N. Z., Lankarani, K. B., Rahimi, M., Mobini, M., Jafarnejad, S., Vahedpoor, Z., & Asemi, Z. (2018) · Phytotherapy Research · doi:10.1002/ptr.6226 · Cited by 161 · see citing works
Sahebkar, A. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.09.012 · Cited by 149 · see citing works
The effect of curcumin on lipid level in patients with acute coronary syndrome.
Alwi, I., Santoso, T. I., Suyono, S., Sutrisna, B., Suyatna, F. D., Kresno, S. B., & Ernie, S. (2008) · PubMed · Cited by 144 · see citing works
Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children
Cutfield, W. S., Jefferies, C., Jackson, W. E., Robinson, E. M., & Hofman, P. L. (2003) · Pediatric Diabetes · doi:10.1034/j.1399-5448.2003.t01-1-00022.x · Cited by 143 · see citing works
Curcumin effects on blood lipid profile in a 6-month human study
Baum, L., Cheung, S. K. K., Mok, V., Lam, L. C. W., Leung, V., Hui, E., Ng, C., Chow, M., Ho, P. C., & Lam, S. S. L. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.013 · Cited by 142 · see citing works
Homburg, R. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.07.009 · Cited by 141 · see citing works
Dyslipidemia and Oxidative Stress in PCOS
Μacut, D., Bjekić-Macut, J., & Savic-Radojevic, A. R. (2012) · Frontiers of hormone research · doi:10.1159/000341683 · Cited by 139 · see citing works
Trikudanathan, S. (2014) · Medical Clinics of North America · doi:10.1016/j.mcna.2014.09.003 · Cited by 138 · see citing works
Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
Reddy, P. S., Begum, N., Mutha, S., & Bakshi, V. (2016) · Asian Pacific Journal of Reproduction · doi:10.1016/j.apjr.2016.01.006 · Cited by 138 · see citing works
Jin, T., Song, Z., Weng, J., & Fantus, I. G. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00285.2017 · Cited by 128 · see citing works
Di Pierro, F., Bressan, A., Ranaldi, D., Rapacioli, G., Giacomelli, L., & Bertuccioli, A. (2015) · PubMed · Cited by 122 · see citing works
Antihyperlipidemic Effect of Curcumin and Tetrahydrocurcumin in Experimental Type 2 Diabetic Rats
Pari, L., & Murugan, P. (2007) · Renal Failure · doi:10.1080/08860220701540326 · Cited by 117 · see citing works
Kotze, D., & Snowden, E. U. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.011 · Cited by 108 · see citing works
The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria.
Mehrabian, F., Khani, B., Kelishadi, R., & Ghanbari, E. (2011) · PubMed · Cited by 104 · see citing works
Hajri, T., Tao, H., Wattacheril, J. J., Marks–Shulman, P. A., & Abumrad, N. N. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00307.2010 · Cited by 103 · see citing works
Park, H. J., Lee, H., Choi, M. S., Son, D. J., Song, H. S., Song, M. J., Lee, J. M., Han, S., Kim, Y., & Hong, J. T. (2008) · Journal of Inflammation · doi:10.1186/1476-9255-5-7 · Cited by 101 · see citing works
Role of Oxidative Stress in Polycystic Ovary Syndrome
Lee, J. Y., Baw, C., Gupta, S., Aziz, N., & Agarwal, A. K. (2010) · Current Women s Health Reviews · doi:10.2174/157340410791321336 · Cited by 99 · see citing works
Razavi, M., Jamilian, M., Kashan, Z. F., Heidar, Z., Mohseni, M., Ghandi, Y., Bagherian, T., & Asemi, Z. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0035-1559604 · Cited by 91 · see citing works
An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio
Ramírez-Boscá, A., Soler, A., Carrión, M. A., Dı́az-Alperi, J., Bernd, A., Quintanilla, C., Almagro, E. Q., & Miquel, J. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00169-x · Cited by 87 · see citing works
Manjunatha, H., & Srinivasan, K. (2007) · Lipids · doi:10.1007/s11745-007-3120-y · Cited by 82 · see citing works
Kocher, A., Bohnert, L., Schiborr, C., & Frank, J. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501034 · Cited by 81 · see citing works
Franco‐Robles, E., Campos-Cervantes, A., Murillo-Ortiz, B. O., Segovia, J., López-Briones, S., Vergara, P., Pérez‐Vázquez, V., Ortíz, M. S. S., & Ramı́rez-Emiliano, J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0133 · Cited by 81 · see citing works
Optimized Turmeric Extracts have Potent Anti-Amyloidogenic Effects
Shytle, R. D., Bickford, P. C., Rezai-Zadeh, K. P., Hou, L., Zeng, J., Tan, J., Sanberg, P. R., Sanberg, C. D., Roschek, B., Fink, R. C., et al. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147115 · Cited by 59 · see citing works
Tabrizi, R., Vakili, S., Lankarani, K. B., Akbari, M., Mirhosseini, N. Z., Ghayour‐Mobarhan, M., Ferns, G. A., Karamali, F., Karamali, M., Taghizadeh, M., et al. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180828162053 · Cited by 57 · see citing works
Mohammadi, S., Karimzadeh, L., Hojati, V., Ghorbani, A. G., & Nabiuni, M. (2017) · PubMed Central · doi:10.22074/cellj.2017.4415 · Cited by 56 · see citing works
Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome
González, F., Sia, C. L., Stanczyk, F. Z., Blair, H. E., & Krupa, M. E. (2012) · Endocrine · doi:10.1007/s12020-012-9728-6 · Cited by 48 · see citing works
Skrypnik, K., Bogdański, P., Sobieska, M., & Suliburska, J. (2019) · Food & Function · doi:10.1039/c9fo01006h · Cited by 42 · see citing works
Effect of Curcumin on Anthropometric Measures: A Systematic Review on Randomized Clinical Trials
Hariri, M., & Haghighatdoost, F. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1392263 · Cited by 33 · see citing works
Stȩpień, M., Kujawska-Łuczak, M., Szulińska, M., Kręgielska-Narożna, M., Skrypnik, D., Suliburska, J., Skrypnik, K., Reguła, J., & Bogdański, P. (2018) · PubMed · doi:10.26402/jpp.2018.2.13 · Cited by 21 · see citing works
The effect of curcumin on the estradiol valerate-induced polycystic ovary in rats
Nabiuni, M., Mohammadi, S., Kayedpoor, P., & Karimzadeh, L. (2015) · KAUMS Journal · Cited by 18 · see citing works
Skrypnik, D., Bogdański, P., Skrypnik, K., Mądry, E., Karolkiewicz, J., Szulińska, M., Suliburska, J., & Walkowiak, J. (2019) · Medicine · doi:10.1097/md.0000000000014909 · Cited by 17 · see citing works
Link between oxidative stress and insulin resistance.
Li, L., & Li, J. (2007) · PubMed · Cited by 12 · see citing works
Eke, C. B., Chukwu, B. F., Ikefuna, A., Ezenwosu, O. U., & Emodi, I. J. (2015) · Pediatric Hematology and Oncology · doi:10.3109/08880018.2015.1010111 · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity
Cowan, S., Lim, S. S., Alycia, C., Pirotta, S., Thomson, R. L., Gibson‐Helm, M. E., Blackmore, R., Naderpoor, N., Bennett, C., Ee, C., et al. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01208-y · Cited by 285 · see citing works
Dehzad, M. J., Ghalandari, H., Nouri, M., & Askarpour, M. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156144 · Cited by 201 · see citing works
Curcumin in Metabolic Health and Disease
Jabczyk, M., Nowak, J., Hudzik, B., & Zubelewicz‐Szkodzińska, B. (2021) · Nutrients · doi:10.3390/nu13124440 · Cited by 148 · see citing works
Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome
Alesi, S., Ee, C., Moran, L., Rao, V. S., & Mousa, A. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab141 · Cited by 180 · see citing works
Turmeric and Curcumin: From Traditional to Modern Medicine
Akaberi, M., Sahebkar, A., & Emami, S. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-56153-6_2 · Cited by 136 · see citing works
Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials
Panknin, T., Howe, C. L., Hauer, M., Bucchireddigari, B., Rossi, A., & Funk, J. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054476 · Cited by 111 · see citing works
Health benefits, extraction and development of functional foods with curcuminoids
Munekata, P. E. S., Pateiro, M., Zhang, W., Domínguez, R., Xing, L., Fierro, E. M., & Lorenzo, J. M. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104392 · Cited by 86 · see citing works
Chien, Y.-J., Chang, C., Wu, M., Chen, C., Horng, Y.-S., & Wu, H.-C. (2021) · Nutrients · doi:10.3390/nu13020684 · Cited by 80 · see citing works
Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review
Kamal, D. A. M., Salamt, N., Yusuf, A. N. M., Kashim, M. I. A. M., & Mokhtar, M. H. (2021) · Nutrients · doi:10.3390/nu13093126 · Cited by 88 · see citing works
An update of polycystic ovary syndrome: causes and therapeutics options
Rababa’h, A. M., Matani, B. R., & Yehya, A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11010 · Cited by 73 · see citing works
Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?
Filardi, T., Varı́, R., Ferretti, E., Zicari, A., Morano, S., & Santangelo, C. (2020) · Nutrients · doi:10.3390/nu12103179 · Cited by 51 · see citing works
Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism
Chen, H., Deng, C., Meng, Z., & Meng, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.956772 · Cited by 50 · see citing works
Gorabi, A. M., Abbasifard, M., Imani, D., Aslani, S., Razi, B., Alizadeh, S., Bagheri‐Hosseinabadi, Z., Sathyapalan, T., & Sahebkar, A. (2021) · Phytotherapy Research · doi:10.1002/ptr.7284 · Cited by 50 · see citing works
Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis
Shen, W., Qu, Y., Jiang, H., Wang, H., Pan, Y., Zhang, Y., Wu, X., Han, Y., & Zhang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1051111 · Cited by 42 · see citing works
Corrie, L., Gulati, M., Vishwas, S., Kapoor, B., Singh, S. K., Awasthi, A., & Khursheed, R. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110644 · Cited by 40 · see citing works
Dehzad, M. J., Ghalandari, H., Amini, M. R., & Askarpour, M. (2023) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2023.102955 · Cited by 39 · see citing works
Shen, W., Jin, B., Pan, Y., Han, Y., You, T., Zhang, Z., Qu, Y., Liu, S., & Zhang, Y. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6619597 · Cited by 39 · see citing works
Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role?
Varı́, R., Scazzocchio, B., Silenzi, A., Giovannini, C., & Masella, R. (2021) · Nutrients · doi:10.3390/nu13031021 · Cited by 35 · see citing works
Targeting dysregulated lipid metabolism in the tumor microenvironment
Kim, D., Song, N., & Yim, H. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01473-y · Cited by 35 · see citing works
Gharaei, R., Mahdavinezhad, F., Samadian, E., Asadi, J., Ashrafnezhad, Z., Kashani, L., & Amidi, F. (2021) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-021-02342-7 · Cited by 33 · see citing works
Akter, T., Zahan, M. S., Nawal, N. N. A., Rahman, M. H., Tanjum, T. N., Arafat, K. I., Moni, A., Islam, M. N., & Uddin, M. J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16957 · Cited by 31 · see citing works
Tang, F., Liu, D., Zhang, L., Xu, L.-Y., Zhang, J., Zhao, X., Ao, H., & Peng, C. Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106953 · Cited by 30 · see citing works
Jafari, A., Abbastabar, M., Alaghi, A., Heshmati, J., Crowe, F. L., & Sepidarkish, M. (2024) · Phytotherapy Research · doi:10.1002/ptr.8340 · Cited by 30 · see citing works
Recent updates on clinical developments of curcumin and its derivatives
Joshi, P., Bisht, A., Paliwal, A., Dwivedi, J., & Sharma, S. K. (2023) · Phytotherapy Research · doi:10.1002/ptr.7974 · Cited by 30 · see citing works
Abdelazeem, B., Abbas, K. S., Shehata, J., Baral, N., Banour, S., & Hassan, M. (2021) · Phytotherapy Research · doi:10.1002/ptr.7274 · Cited by 29 · see citing works
Copper in Gynecological Diseases
Conforti, R. A., Delsouc, M. B., Zorychta, E., Telleria, C. M., & Casais, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417578 · Cited by 29 · see citing works
Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works
“Another study involving 51 women found that curcumin improved insulin sensitivity (QUICKI index) after six weeks of supplementation but did not significantly alter lipid or glycemic markers compared to placebo [203].”
Labban, R. S. M., Alfawaz, H., Almnaizel, A. T., Al-Muammar, M. N., Bhat, R. S., & El-Ansary, A. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-86545-z · Cited by 26 · see citing works
Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets
Tan, W., Zhang, J., Dai, F., Yang, D., Gu, R., Tang, L., Liu, H., & Cheng, Y. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04736-w · Cited by 25 · see citing works
Chang, G., Hsieh, W., Chou, L.-S., Lin, C., Wu, C.-F., Lin, J.-W., Lin, W.-L., Lin, W., Liao, H.-J., Kao, C.-Y., et al. (2021) · Processes · doi:10.3390/pr9071132 · Cited by 24 · see citing works
ElRakabawy, O. M., El-Kholy, A. A.-E. S., Mahfouz, A. A., Abdelsalam, M., & Wakeel, L. M. E. (2025) · Scientific Reports · doi:10.1038/s41598-025-09783-5 · Cited by 24 · see citing works
Chinese herbal medicine for subfertile women with polycystic ovarian syndrome
Zhou, K., Zhang, J., Xu, L., & Lim, C. E. D. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007535.pub4 · Cited by 26 · see citing works
Chen, K., Gao, Z., Ding, Q., Tang, C., Zhang, H., Zhai, T., Xie, W., Jin, Z., Zhao, L., & Liu, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.962720 · Cited by 24 · see citing works
Morvaridzadeh, M., Agah, S., Estêvão, M. D., Hoseini, A. S., Heydari, H., Toupchian, O., Abdollahi, S., Persad, E., Abu‐Zaid, A., Rezamand, G., et al. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2463 · Cited by 23 · see citing works
Surma, S., Sahebkar, A., Urbański, J., Penson, P. E., & Banach, M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.865497 · Cited by 23 · see citing works
Polycystic ovarian syndrome: A review covering phytoconstituents for its outstrip management
Joshi, M., Shankar, R., Pathak, K., & Yadav, R. (2021) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100011 · Cited by 23 · see citing works
Soltani, M., Hosseinzadeh‐Attar, M. J., Rezaei, M., Alipoor, E., Vasheghani‐Farahani, A., Yaseri, M., & Rezayat, S. M. (2024) · Trials · doi:10.1186/s13063-024-08354-9 · Cited by 22 · see citing works
Rafiee, S., Bagherniya, M., Askari, G., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-56153-6_10 · Cited by 21 · see citing works
Alaee, S., Khodabandeh, Z., Dara, M., Hosseini, E., & Sharma, M. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4076 · Cited by 20 · see citing works
Chavez, G. N., Jaworsky, K., & Basu, A. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20156534 · Cited by 19 · see citing works
Hassan, M. H., Awadalla, E. A., El-Kader, A. E.-K. M. A., Seifeldin, E. A., Mahmoud, M. A., Muddathir, A. R. M., & Abdelsadik, A. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9707278 · Cited by 19 · see citing works
Talebpour, A., Mohammadifard, M., Zare‐Feyzabadi, R., Mahmoudzadeh, S., Rezapour, H., Saharkhiz, M., Tajik, M., Ferns, G. A., & Bahrami, A. (2023) · Physiological Reports · doi:10.14814/phy2.15763 · Cited by 19 · see citing works
He, J., Deng, R., Wei, Y., Zhang, S., Su, M., Tang, M., Wang, J., Nong, W., & Lei, X. (2024) · Food & Function · doi:10.1039/d3fo02824k · Cited by 19 · see citing works
Salekzamani, Y., Shakouri, S. K., Dolatkhah, N., Saleh, P., & Hashemian, M. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100746 · Cited by 16 · see citing works
Kamal, D. A. M., Ibrahim, S. F., Ugusman, A., & Mokhtar, M. H. (2022) · Antioxidants · doi:10.3390/antiox11101879 · Cited by 18 · see citing works
Simental‐Mendía, L. E., Shah, N. Z., Sathyapalan, T., Majeed, M. A., Orekhov, A. N., Jamialahmadi, T., & Sahebkar, A. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00761-6 · Cited by 15 · see citing works
Lee, Y., & Kim, Y. (2024) · Nutrients · doi:10.3390/nu16111728 · Cited by 15 · see citing works
Agame-Lagunes, B., Grube-Pagola, P., García‐Varela, R., Alexander-Aguilera, A., & Garcia, H. S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040509 · Cited by 14 · see citing works
Tehrani, S. D., Shojaei, M., Bagherniya, M., Pirro, M., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7763 · Cited by 13 · see citing works
Balieiro, C. C. A., Hespanhol, L. C., Fonseca, L. M., Wantowski, S., Freitas, M. A. A., Dias, Y. J. M., Burlá, M. M., & de Oliveira, L. M. L. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.12.038 · Cited by 13 · see citing works
Mallya, P., Yarlagadda, D. L., & Lewis, S. A. (2024) · Food Analytical Methods · doi:10.1007/s12161-024-02606-9 · Cited by 13 · see citing works
Curcumin and Polycystic Ovary Syndrome: a Systematic Review
Shojaei‐Zarghani, S., Molani‐Gol, R., & Rafraf, M. (2022) · Reproductive Sciences · doi:10.1007/s43032-021-00826-6 · Cited by 13 · see citing works
Zhao, G., Fan, Y., Li, R., Huang, Y. S., Li, W., Zhao, Y., Zhou, M., & He, J. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01409-9 · Cited by 12 · see citing works
Dehzad, M. J., Ghalandari, H., Nouri, M., & Askarpour, M. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102855 · Cited by 11 · see citing works
Kamal, D. A. M., Ibrahim, S. F., Ugusman, A., & Mokhtar, M. H. (2022) · Life · doi:10.3390/life12060890 · Cited by 11 · see citing works
Wang, X., Zhang, W., & Zhou, S. (2024) · Phytotherapy Research · doi:10.1002/ptr.8208 · Cited by 12 · see citing works
Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative
Bandala, C., Cárdenas‐Rodríguez, N., Reyes-Long, S., Cortes-Altamirano, J. L., Garciadiego-Cázares, D., Lara‐Padilla, E., Ibáñez-Cervantes, G., Mancilla-Ramı́rez, J., Gómez‐Manzo, S., & Alfaro-Rodríguez, A. (2022) · Antioxidants · doi:10.3390/antiox11101972 · Cited by 10 · see citing works
Zamani, S. K., & Rezagholizadeh, M. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.04.002 · Cited by 10 · see citing works
Saleem, H. M., Al‐Hetty, H. R. A. K., Ahmed, A. T., Awad, M. M., Al-Ani, M. Q., Al-Darraji, M. N., Salman, D. A., & Ali, L. H. (2025) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106947 · Cited by 9 · see citing works
Deng, Z., Yang, K., Cai, X., Mei, H., Xiao, H., & Gao, W. (2023) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2023.1167913 · Cited by 9 · see citing works
Uluğ, E., & Açıkgöz, A. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00488-7 · Cited by 8 · see citing works
Khamar, T., Jahani, N., Jafari‐Nozad, A. M., Farkhondeh, T., & Samarghandian, S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673320502241002075427 · Cited by 8 · see citing works
Kehinde, S. A., Qaisrani, Z. N., Pattanayaiying, R., Lay, B. B., Phyo, K. Y., Lin, W. P., San, M. M., Awaeloh, N., Aunsorn, S., Kitkangplu, R., et al. (2025) · Foods · doi:10.3390/foods15010060 · Cited by 8 · see citing works
Safari, Z., Bagherniya, M., Askari, G., Sathyapalan, T., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-56153-6_7 · Cited by 7 · see citing works
Phytotherapy in Polycystic Ovary Syndrome (PCOS) Management: A Systematic Review
Mohamed, S. S., Allam, A. T., Elalfy, A., El‐Shiekh, R. A., Reda, A. M., & Hafeez, M. S. A. E. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500982 · Cited by 6 · see citing works
Mohammadi, F., Mohsenpour, M. A., Sohrabi, Z., Niakousari, M., Jeddi, M., Hassanzadeh, J., Ferns, G. A., & Eftekhari, M. H. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3839 · Cited by 6 · see citing works
Could polyphenols be an effective treatment in the management of polycystic ovary syndrome?
Irmak, E., Şanlıer, N. T., & Şanlıer, N. (2024) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000802 · Cited by 6 · see citing works
Khursheed, R., Singh, S. K., Wadhwa, S., Gulati, M., Jha, N. K., Gupta, G., Devkota, H. P., Prasher, P., Chellappan, D. K., & Dua, K. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2022.04.021 · Cited by 6 · see citing works
Jian, X., Shi, C., Xu, T., Liu, B., Zhou, L., Jiang, L., & Liu, K. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2440063 · Cited by 5 · see citing works
Mohammadi, S., Ziaei, S., Morvaridi, M., Hasani, M., Mirtaheri, E., Farsi, F., Ebrahimi, S., Daneshzad, E., & Heshmati, J. (2025) · Health Science Reports · doi:10.1002/hsr2.70525 · Cited by 5 · see citing works
Wang, R., Miao, C., Chen, Y., Zhao, Y., Yang, L., Cheng, W., & Zhang, Q. (2022) · Gynecological Endocrinology · doi:10.1080/09513590.2022.2148648 · Cited by 5 · see citing works
Scannell, N., Mantzioris, E., Rao, V. S., Pandey, C., Ee, C., Mousa, A., Moran, L., & Villani, A. M. (2023) · Biomedicines · doi:10.3390/biomedicines11123349 · Cited by 5 · see citing works
Nouri, M., Sohaei, S., Shalaby, M. N., Mehrabani, S., Ramezani, A., & Faghih, S. (2022) · Nutrition & Food Science · doi:10.1108/nfs-11-2021-0334 · Cited by 5 · see citing works
Self-citationFakhri, F., Fakhri, S., Shakeryan, S., & Alizadeh, A. (2020) · Complementary Medicine Journal · doi:10.32598/cmja.10.1.994.1 · Cited by 5 · see citing works
Jiang, X., Wang, Y., Hua, Y., Tang, H., & Li, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1610869 · Cited by 4 · see citing works
Li, X., Yi, Y., Ren, Y., Zhang, Y., Wang, C. C., Liu, C., Liu, S., Zhan, X., Yu, X., & Liang, R. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13918 · Cited by 4 · see citing works
Polycystic Ovary Syndrome Herbal Treatments and Medicinal Plants: A Comprehensive Review
Goudarzi, K., Kamalpour, J., Zekri, S., Aringazina, R. A., Sharoffidin, R. S., Tamadon, A., & Tanideh, N. (2025) · Journal of Infertility and Reproductive Biology · doi:10.18502/jirb.v13i1.18766 · Cited by 4 · see citing works
Şanlıer, N. T., Saçıntı, K. G., Türkoğlu, İ., & Şanlıer, N. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1761721 · Cited by 3 · see citing works
Mthembu, S. X. H., Mazibuko-Mbeje, S. E., Silvestri, S., Orlando, P., Nkambule, B. B., Muller, C. J. F., Tiano, L., & Dludla, P. V. (2025) · Food Reviews International · doi:10.1080/87559129.2024.2449378 · Cited by 3 · see citing works
Victoria‐Montesinos, D., Cerdá, B., Zafrilla, P., Ballester, P., & García‐Muñoz, A. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125565 · Cited by 3 · see citing works
Önder, A., Yılmaz, Ö. D., Çınar, A. S., & Kızılay, H. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815196801124030003 · Cited by 2 · see citing works
Fauth, J. D. A., Beserra, B. T. S., Garcia, É. C., & Amato, A. A. (2026) · Phytomedicine Plus · doi:10.1016/j.phyplu.2026.100962 · Cited by 2 · see citing works
Complementary administration of curcumin in PCOS: a systematic review
Venkatesan, K., Menon, S., Firoz, I. N., Narendrula, R., Kunnath, J. T., KALAPURAKAL, A. M., Ashok, A., IQBAL, A. M., & Haroon, N. N. (2022) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.22.05129-6 · Cited by 2 · see citing works
Bi̇lgi̇n, G. D., Büyükuslu, N., Eyüpoğlu, O. E., & Cumbul, A. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106784 · Cited by 2 · see citing works
Awadalla, E. A., El-Baga, S. E., Gabr, S. A., Gelany, W. I., & Ali, R. A. (2023) · Cell and Tissue Biology · doi:10.1134/s1990519x23060032 · Cited by 1 · see citing works
Efficacy of Herbal Medicines in Management of Polycystic Ovarian Syndrome: A Scoping Review
Deupa, H., & Shankar, P. (2024) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v14i4.4212 · Cited by 1 · see citing works
Andres-Montenegro, N., Molina-Gutierrez, S., & Murillo, O. I. N. (2025) · Bionatura journal : · doi:10.70099/bj/2025.02.02.13 · Cited by 1 · see citing works
Natural Compounds with Pharmacological Properties in Clinical Trials
Noormohammadi, M., & Shidfar, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-28780-0_46 · Cited by 1 · see citing works
Nutritional Management of Polycystic Ovary Syndrome: Insights into Diet and Nutrition Strategies
Jan, B., Ahmad, S., Ibrahim, M., & Choudhary, B. (2024) · Natural Resources for Human Health · doi:10.53365/nrfhh/183616 · Cited by 1 · see citing works
Dolatshahi, K., Mosaheb, S. A., Foodani, M. N., Hosseininezahdian, S., & Esfahan, S. Z. (2024) · ACTA MEDICA IRANICA · doi:10.18502/acta.v61i11.16081 · Cited by 1 · see citing works
de Oliveira, T. F., da Silva, M. J. A. A., & Salomón, A. L. R. (2022) · Research Society and Development · doi:10.33448/rsd-v11i8.31425 · Cited by 1 · see citing works
Effect of Turmeric Herbal on Polycystic Ovary Syndrome: A Systematic Review
Kundarti, F. I., Komalyna, I. N. T., & Riyadi, B. D. (2023) · International Journal of Current Science Research and Review · doi:10.47191/ijcsrr/v6-i9-37 · Cited by 1 · see citing works
Demir, S. S., Demir, B., Sakar, M. N., Paşa, S., & Atamer, Y. (2020) · doi:10.21203/rs.2.22028/v1
Diet, Nutritional Supplements, and Botanical Medicine in Polycystic Ovary Syndrome
Lucius, K. (2021) · Alternative and Complementary Therapies · doi:10.1089/act.2021.29356.klu
Os efeitos da curcumina e seu potencial como tratamento na Síndrome dos Ovários Policísticos
Sousa, C. G. D. A., Pereira, C. N. P., Pires, B. I., Saggioro, V. M., de Freitas, F. L., & Santana, J. A. P. D. C. (2024) · Contribuciones a las Ciencias Sociales · doi:10.55905/revconv.17n.6-031
Bioprospecting Nutraceuticals for Human Welfare
Hegde, M., Mishra, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2024) · Springer eBooks · doi:10.1007/978-3-031-71674-4_16
Curcumin in Atherogenic Dyslipidemia: Linking Preclinical Mechanistic Insights to Clinical Outcomes
Brodziński, K., Juszczyńska, J., Karbowska, J., & Kochan, Z. (2026) · Nutrients · doi:10.3390/nu18142279
Hameed, R. Y. (2026) · Regulatory Mechanisms in Biosystems · doi:10.15421/0226087
Suresh, A., Jayaprakasan, J., Venkatesan, R., Soujanya, C., & Selvaraj, D. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.107117
- Authors
- Sohaei, S., Amani, R., Tarrahi, M. J., & Ghasemi-Tehrani, H.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Amani, Reza
- Venue
- Complementary Therapies in Medicine
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 47
- Pages
- 102201
- ISSN
- 0965-2299 (ISSN-L)
- OpenAlex
- W2977196190
- Cited by
- 100
- References
- 73
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 17 · 2023: 25 · 2022: 14 · 2021: 23 · 2020: 3
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Complementary Therapies in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Isfahan University of Medical Sciences
- Vice-Chancellor for Research, Shiraz University of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- curcumin, polycystic ovary syndrome, overweight women, obesity, insulin resistance, glycemic control, lipid profile, C-reactive protein, QUICKI, HOMA-IR, serum insulin, triglycerides, LDL/HDL ratio
- MeSH terms
- Adult, C-Reactive Protein, Curcumin, Double-Blind Method, Female, Humans, Hyperinsulinism, Hyperlipidemias, Obesity, Polycystic Ovary Syndrome, Dietary Supplements, Overweight
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