Motor and cognitive deficits in mice bred to have low or high blood pressure
Abstract
Deviations from normal blood pressure can lead to a number of physiological and behavioral complications. We tested the hypothesis that hyper- or hypotension is associated with significant differences in motor activity and coordination, anxiety levels, and spatial learning and memory in male and female mice. Compared to normotensive control mice, hypertensive mice were hyperactive and their performance was significantly worse on the rotarod (males only), cued learning (males only), spatial learning/re-learning, and spatial memory. Hypotensive mice of both genders swam more slowly and performed even worse than hypertensive mice on the rotarod, cued learning, spatial learning/re-learning, and spatial memory tasks. Across all phenotypes, females were generally more active than males in the open field and exhibited more anxiety-like behaviors in the elevated zero maze. Alterations in hemodynamics and/or neurovascular unit function may account for the observed behavioral changes in the hypo- and hypertensive mice.
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BPH/2J mice are a model of spontaneous lifelong hypertension with well-documented and reproducible cognitive deficits.
“In this study, we elected to use middle-aged BPH/2J mice, a model of spontaneous lifelong hypertension resulting in well-documented and reproducible cognitive deficits (38).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [38]
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- Authors
- Hartman, R. E., Kamper, J. E., Goyal, R., Stewart, J. M., & Longo, L. D.
- Affiliations
- Loma Linda University (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 105
- Issue
- 4
- Pages
- 1092-1097
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2029504712
- Cited by
- 25
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD003807)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hypertension, hypotension, blood pressure, motor coordination, anxiety-like behavior, spatial learning and memory, sex differences, rotarod test, elevated zero maze, open field behavior, neurovascular unit, hemodynamics
- MeSH terms
- Animals, Blood Pressure, Female, Hypertension, Hypotension, Male, Mice, Inbred Strains, Motor Activity, Maze Learning, Rotarod Performance Test, Mice
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