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Making artemisinin
Open accessAbstract
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
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“Instead, the chemistry of undifferentiated callus and suspension cultures of A. annua seems to be dominated by sterols, such as stigmasterol (570) and sitosterol (568) (Section 2.7.2) [86,313]; as well as phenylpropanoids, such as scopoletin (184) (Section 2.3; Table 17), all of which are also found in significant quantities in the parent plants [86,313].”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [313]
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- Li, Y.,Huang, H., Wu, Y.-L., 2006, qinghaosu (artemisinin) - a fantastic antimalarial drug from a traditional Chinese medicine. In: Liang, X.-T., Fang, W.-S. (Eds.), Medicinal Chemistry of Bioactive Natural Products Wiley Interscience, Hoboken, pp. 183-256.
- Willcox, M., Bodeker, G., Bourdy, G., Dhingra, V., Falquet, J., Ferreira, J.F.S., Graz, B., Hirt, H.-M., Hsu, E., Melillo de Magalhaes, P., Provendier, D., Wright, C.W., 2004. Artemisia annua as a traditional herbal antimalarial. In: Willcox, M., Bodeker, G., Rasoanaivo, P. (Eds.), Traditional Medicinal Plants and Malaria CRC Press, Boca Raton, pp. 43-59.
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“Another reason why a putative immediate artemisinin precursor dihydroartemisinic acid has not eventually led to the generation of artemisinin is that the non-enzymatic conversion of dihydroartemisinic acid to artemisinin is actually unclear, as illustrated in Figure 1 (Covello 2008).”
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Metadata
- Authors
- Covello, P. S.
- Affiliations
- Plant Biotechnology Institute (CA)
- Corresponding author
- Covello, Patrick S.
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 69
- Issue
- 17
- Pages
- 2881-2885
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W4236404432
- Cited by
- 127
- References
- 0
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 9
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- NPARC (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
- Keywords
- artemisinin, antimalarial drugs, Artemisia annua, biosynthesis, genetic modification, microbial engineering, total synthesis, semisynthesis, drug production
- MeSH terms
- Escherichia coli, Genetic Engineering, Molecular Structure, Artemisia, Artemisinins
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