Cited by 127Plant biochemistry and biosynthesisSesquiterpenes and Asteraceae StudiesPlant tissue culture and regeneration

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Making artemisinin

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Covello, Patrick S.·2008·Phytochemistry

DOI 10.1016/j.phytochem.2008.10.001

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Abstract

The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.

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Li, Y.,Huang, H., Wu, Y.-L., 2006, qinghaosu (artemisinin) - a fantastic antimalarial drug from a traditional Chinese medicine. In: Liang, X.-T., Fang, W.-S. (Eds.), Medicinal Chemistry of Bioactive Natural Products Wiley Interscience, Hoboken, pp. 183-256.
Willcox, M., Bodeker, G., Bourdy, G., Dhingra, V., Falquet, J., Ferreira, J.F.S., Graz, B., Hirt, H.-M., Hsu, E., Melillo de Magalhaes, P., Provendier, D., Wright, C.W., 2004. Artemisia annua as a traditional herbal antimalarial. In: Willcox, M., Bodeker, G., Rasoanaivo, P. (Eds.), Traditional Medicinal Plants and Malaria CRC Press, Boca Raton, pp. 43-59.

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Sesquiterpenes
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A phylogenetic perspective of antiviral species of the genus Artemisia (Asteraceae-Anthemideae): A proposal of anti SARS-CoV-2 (COVID-19) candidate taxa
Hussain, A. (2022) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2022.100601 · Cited by 19
“Artemisinin is a sesquiterpenoid lactone present in the extracts of different Artemisia species, including A. annua (Covello, 2008; Ikram and Simonsen, 2017; Pellicer et al., 2018; Nganthoi and Sanatombi, 2019) A. apiacea, A. macrocephala and A. thuscula (Pellicer et al., 2018), with 1, 2,…”
Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities
Abdou, A. M., Seddek, A., Abdelmageed, N., et al. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03566-5 · Cited by 16
A regulated synthetic operon facilitates stable overexpression of multigene terpenoid pathway in Bacillus subtilis
Abdallah, I. I., Xue, D., Pramastya, H., et al. (2020) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-019-02257-4 · Cited by 16
Artemisinin content and DNA profiling of Artemisia species of Manipur
Nganthoi, M., & Sanatombi, K. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.06.027 · Cited by 16
Nonclassical CH−π Supramolecular Interactions in Artemisinic Acid Favor a Single Conformation, Yielding High Diastereoselectivity in the Reduction with Diazene
CASTRO, B., Chaudret, R., Ricci, G., Kurz, M. E., Ochsenbein, P., Kretzschmar, G., Kraft, V., Rossen, K., & Eisenstein, O. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo500233z · Cited by 15
Synthesis of the artemisinin‐imprinting polymers on silica surface and its adsorption behavior in supercritical CO2 fluid
Yang, B., & Cao, X. (2011) · AIChE Journal · doi:10.1002/aic.12547 · Cited by 15
Metabolic analyses elucidate non-trivial gene targets for amplifying dihydroartemisinic acid production in yeast
Misra, A., Conway, M. F., Johnnie, J., Qureshi, T. M., Lige, B., Derrick, A. M., Agbo, E. C., & Sriram, G. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00200 · Cited by 14
““fmicb-04-00200” — 2013/7/24 — 20:28 — page 1 — #1 ORIGINAL RESEARCH ARTICLE published: 26 July 2013 doi: 10.3389/fmicb.2013.00200 Metabolic analyses elucidate non-trivial gene targets for amplifying dihydroartemisinic acid production in yeast”
BackgroundInfluential
AaWRKY4 upregulates artemisinin content through boosting the expressions of key enzymes in artemisinin biosynthetic pathway
Huang, H., Xing, S., Tang, K., & Jiang, W. (2021) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-021-02049-8 · Cited by 14
“2002; Covello 2008).”
Background
Optimization of Ultrasound-Assisted Extraction of Artemisinin fromArtemisia annuaL. by Response Surface Methodology
Zhang, H., Zhang, L. R., Hu, X., Zhou, Y., Ding, C., Yang, R., Wang, X., & Li, D. (2013) · Separation Science and Technology · doi:10.1080/01496395.2013.862545 · Cited by 13
Asymmetric Bio‐epoxidation of Unactivated Alkenes
Li, J., Gu, W., Wang, Z., et al. (2023) · ChemBioChem · doi:10.1002/cbic.202200719 · Cited by 13
Singlet oxygen as a signaling transducer for modulating artemisinin biosynthetic genes in Artemisia annua
Zeng, Q. P., Zeng, X.-M., Yang, R., & Yang, X. (2011) · Biologia Plantarum · doi:10.1007/s10535-011-0166-8 · Cited by 12
“Following catalysis by Δ11(13)-doublebond reductase 2 (DBR2), artemisinic aldehyde is reduced to dihydroartemisinic aldehyde, which is then oxidized to dihydroartemisinic acid (DHAA) by a trichome-specific aldehyde dehydrogenase, ALDH1 (Covello 2008).”
BackgroundInfluential
STUDY OF EFFECT OF EXTRACTION CONDITIONS ON THE BIOCHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF ARTEMISIA ABSINTHIUM BY HPLC AND TLC
Ghafouri, H., Sariri, R., & Naghavi, M. R. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2013.803200 · Cited by 12
“Artemisinin is a sesquiterpenoid produced in glandular trichomes of Artemisia annua.([16]) Other species of Artemisia have been screened as potential new sources for agricultural production.”
Background
Antimalarial and Antileishmanial Activities of Phytophenolics and Their Synthetic Analogues
Morimoto, M., Cantrell, C. L., Khan, S. I., et al. (2017) · Chemistry & Biodiversity · doi:10.1002/cbdv.201700324 · Cited by 12
Unravelling the Impact of Essential Mineral Nutrients on Active Constituents of Selected Medicinal and Aromatic Plants
Singh, M., Ali, A. A., & Qureshi, M. I. (2017) · Springer eBooks · doi:10.1007/978-3-319-58841-4_9 · Cited by 12
Root regulation of artemisinin production in Artemisia annua: trichome and metabolite evidence
Wang, S., Towler, M. J., & Weathers, P. J. (2016) · Planta · doi:10.1007/s00425-016-2560-0 · Cited by 9
Socioeconomic Values of Herbal Medicine
Odubo, T. C., Iyiola, A. O., Adetola, B. O., Kolawole, A. S., Izah, S. C., Raimi, M. O., & Ogwu, M. C. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-43199-9_3 · Cited by 12
Using β-ocimene to increase the artemisinin content in juvenile plants of Artemisia annua L.
Xiao, M., Liu, R., Long, C., Ruan, Y., & Liu, C. (2020) · Biotechnology Letters · doi:10.1007/s10529-020-02849-6 · Cited by 9
“Currently, it is understood that the precursors for artemisinin biosynthesis originate from the cytosolic mevalonic acid (MVP) pathway and methylerythritol phosphate (MEP) pathway (Covello 2008; Ma et al. 2015).”
Background
New Medical Applications of Plant Secondary Metabolites
Heilmann, J. (2010) · Wiley-Blackwell eBooks · doi:10.1002/9781444318876.ch5 · Cited by 10
Terpenoid Biosynthesis
Ro, D. (2011) · Wiley eBooks · doi:10.1002/9781119991311.ch8 · Cited by 11
Inducing Effect of Dihydroartemisinic Acid in the Biosynthesis of Artemisinins with Cultured Cells ofArtemisia annuaby Enhancing the Expression of Genes
Zhu, J., Yang, J., Zeng, Z., Zhang, W., Song, L., Wen, W., & Yu, R. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/293190 · Cited by 8
Yeast Synthetic Biology for Production of Artemisinin as an Antimalarial Drug
Kashkooli, A. B., Kalalagh, K. F., & Babaei, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-89680-5_6 · Cited by 7
Medicinal Plants: Guests and Hosts in the Heterologous Expression of High-Value Products
Vasilev, N. P. (2021) · Planta Medica · doi:10.1055/a-1576-4148 · Cited by 6
Socioeconomic Values of Herbal Medicine
Odubo, T. C., Iyiola, A. O., Adetola, B. O., Kolawole, A. S., Izah, S. C., Raimi, M. O., & Ogwu, M. C. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-21973-3_3-1 · Cited by 6
Recent Trends on Production Sources, Biosynthesis Pathways and Antiviral Efficacies of Artemisinin: A Candidate Phytomedicine against SARS-CoV-2
Hussain, A. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666230327082051 · Cited by 6

Authors: Covello, P. S.
Affiliations: Plant Biotechnology Institute (CA)
Corresponding author: Covello, Patrick S.
Venue: Phytochemistry
Publisher: Elsevier BV
Published: 2008-12
Volume: 69
Issue: 17
Pages: 2881-2885
ISSN: 0031-9422 (ISSN-L)
DOI: 10.1016/j.phytochem.2008.10.001
OpenAlex: W4236404432
Cited by: 127
References: 0
Citations by year: 2026: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 9
FWCI: 5.33
Type: journal article
Language: en
Open access: green
nrc-publications.canada.ca
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Phytochemistry (publishedVersion)
PubMed (publishedVersion)
NPARC (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
Keywords: artemisinin, antimalarial drugs, Artemisia annua, biosynthesis, genetic modification, microbial engineering, total synthesis, semisynthesis, drug production
MeSH terms: Escherichia coli, Genetic Engineering, Molecular Structure, Artemisia, Artemisinins

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