Cited by 624Pharmacology and Obesity TreatmentBioactive natural compoundsMedicinal Plant Research

The DOI matches its Crossref record; 294 of the 294 references it cites were found in a registry or an index.

Possible anti-obesity therapeutics from nature--a review

Yun, Jong Won·2010·Phytochemistry

DOI 10.1016/j.phytochem.2010.07.011

Open this paper in CoChat — free account

Abstract

Obesity is associated with many diseases, particularly diabetes, hypertension, osteoarthritis, and heart disease. The obesity incidence has increased at an alarming rate in recent years, becoming a worldwide health problem, with incalculable social costs. Two different obesity-treatment drugs are currently on the market: orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase; and sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side-effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. These are mainly complex products having several components with different chemical and pharmacological features. This review aimed to survey the literature covering natural products with anti-obesity activity and to review the scientific data, including experimental methodologies, active components, and mechanisms of action against obesity.

Integrity signals

Registry

Crossref · 10.1016/j.phytochem.2010.07.011

Cites

294 of 294 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Items 201–294 of 294

Anti‐obesity action of Salix matsudana leaves (Part 1). Anti‐obesity action by polyphenols of Salix matsudana in high fat‐diet treated rodent animals
Han, L., Sumiyoshi, M., Zhang, J., Liu, M., Zhang, X., Zheng, Y., Okuda, H., & Kimura, Y. (2003) · Phytotherapy Research · doi:10.1002/ptr.1404 · Cited by 77
Purification and identification of adipogenesis inhibitory peptide from black soybean protein hydrolysate
Kim, H. J., Bae, I. Y., Ahn, C.-W., Lee, S., & Lee, H. G. (2007) · Peptides · doi:10.1016/j.peptides.2007.08.030 · Cited by 76
Anti-obesity and Antidiabetic Effects of Deep Sea Water on ob/ob Mice
Hwang, H. S., Kim, H. A., Lee, S. H., & Yun, J. W. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9171-0 · Cited by 74
Self-citation
Esterastin, an inhibitor of esterase, produced by Actinomycetes.
UMEZAWA, H., AOYAGI, T., Hazato, T., Uotani, K., Kojima, F., HAMADA, M., & TAKEUCHI, T. (1978) · The Journal of Antibiotics · doi:10.7164/antibiotics.31.639 · Cited by 74
Green tea (−)-epigallocatechin gallate inhibits insulin stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor pathway
Ku, H., Chang, H.-H., Liu, H.-C., Hsiao, C.-H., Lee, M.-J., Hu, Y.-J., Hung, P.-F., Liu, C.-W., & Kao, Y.-H. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00272.2008 · Cited by 72
Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain
Lane, M. D., & Cha, S. H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.145 · Cited by 71
Different effects of conjugated linoleic acid isomers on lipoprotein lipase activity in 3T3-L1 adipocytes
Lin, Y., Kreeft, A. J., Schuurbiers, J. A. E., & Draijer, R. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00155-8 · Cited by 70
The effect of Korean pine nut oil (PinnoThin™) on food intake, feeding behaviour and appetite: A double-blind placebo-controlled trial
Hughes, G. M., Boyland, E. J., Williams, N. J., Mennen, L. I., Scott, C. E., Kirkham, T. C., Harrold, J. A., Keizer, H. G., & Halford, J. C. G. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-6 · Cited by 70
Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3-L1 adipose cells
Roffey, B., Atwal, A. S., Johns, T., & Kubow, S. J. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.02.003 · Cited by 68
Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-α-mediated transcription of fatty acid metabolic genes
Huang, T. H.-W., Yang, Q., Harada, M., Uberai, J., Radford, J., Li, G. Q., Yamahara, J., Roufogalis, B. D., & Li, Y. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.07.020 · Cited by 68
Guggulsterone Inhibits Adipocyte Differentiation and Induces Apoptosis in 3T3‐L1 Cells
Yang, J., Della‐Fera, M. A., & Baile, C. A. (2008) · Obesity · doi:10.1038/oby.2007.24 · Cited by 68
Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men
Feltrin, K. L., Little, T. J., Meyer, J. H., Horowitz, M., Rades, T., Wishart, J. M., & Feinle‐Bisset, C. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1181 · Cited by 68
How does sibutramine work?
Lean, M. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801931 · Cited by 68
Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1, 2-diglyceride-based colorimetric assay
Zhao, H. L., & Kim, Y. S. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975852 · Cited by 66
Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats
Kim, Y.-J., Shin, Y., Ha, Y.-W., Lee, S., Oh, J., & Kim, Y. S. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1278 · Cited by 65
A Soybean Peptide Isolate Diet Promotes Postprandial Carbohydrate Oxidation and Energy Expenditure in Type II Diabetic Mice
Ishihara, K., Fukuchi, Y., Segawa, K., Takahashi, M., Mita, Y., Fukuya, Y., YASUMOTO, K., OYAIZU, S., Mizunoya, W., & Fushiki, T. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.752 · Cited by 64
Consumption of an oil composed of medium chain triacyglycerols, phytosterols, and n-3 fatty acids improves cardiovascular risk profile in overweight women
Bourque, C., St‐Onge, M., Papamandjaris, A. A., Cohn, J. S., & Jones, P. J. H. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00070-2 · Cited by 63
Effects of three Chinese herbal medicines on plasma and liver lipids in mice fed a high-fat diet
Nakayama, T., Suzuki, S., Kudo, H., Sassa, S., Nomura, M., & Sakamoto, S. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.07.041 · Cited by 61
American Ginseng Berry Juice Intake Reduces Blood Glucose and Body Weight in ob / ob Mice
Xie, J. T., Wang, C. Z., Ni, M., Wu, J., Mehendale, S. R., Aung, H. H., Foo, A., & Yuan, C. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00481.x · Cited by 61
Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol.
Verma, S. K., & Bordia, A. (1988) · PubMed · Cited by 60
Anti‐adipogenic effects of Garcinia extract on the lipid droplet accumulation and the expression of transcription factor
Kim, M., Kim, J., Kwon, D., & Park, R. (2004) · BioFactors · doi:10.1002/biof.5520220140 · Cited by 60
A Combination of Caffeine, Arginine, Soy Isoflavones, and l-Carnitine Enhances Both Lipolysis and Fatty Acid Oxidation in 3T3-L1 and HepG2 Cells in Vitro and in KK Mice in Vivo
Murosaki, S., Lee, T. R., Muroyama, K., Shin, E. S., Cho, S. Y., Yamamoto, Y., & Lee, S. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.10.2252 · Cited by 60
Anti‐obesity action of Salix matsudana leaves (Part 2). Isolation of anti‐obesity effectors from polyphenol fractions of Salix matsudana
Han, L., Sumiyoshi, M., Zheng, Y., Okuda, H., & Kimura, Y. (2003) · Phytotherapy Research · doi:10.1002/ptr.1405 · Cited by 59
Effect of retinoic acid on differentiation of cultured pig preadipocytes.
Suryawan, A., & Hu, C. Y. (1997) · Journal of Animal Science · doi:10.2527/1997.751112x · Cited by 59
Ajoene exerts potent effects in 3T3‐L1 adipocytes by inhibiting adipogenesis and inducing apoptosis
Ambati, S., Yang, J., Rayalam, S., Park, H. J., Della‐Fera, M. A., & Baile, C. A. (2008) · Phytotherapy Research · doi:10.1002/ptr.2663 · Cited by 58
Hibiscus Extract Inhibits the Lipid Droplet Accumulation and Adipogenic Transcription Factors Expression of 3T3-L1 Preadipocytes
Kim, M., Kim, J.-K., Kim, H. J., Moon, S., Shin, B., Park, K., Yang, H.-O., Kim, S.-M., & Park, R. (2003) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555303322284785 · Cited by 58
Antiobesity Effect of Kochujang (Korean Fermented Red Pepper Paste) Extract in 3T3-L1 Adipocytes
Ahn, I., Do, M., Kim, S., Jung, H.-S., Kim, Y., Kim, H. J., & Park, K.-Y. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.15 · Cited by 57
(-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation
Sakurai, N., Mochizuki, K., Kameji, H., Shimada, M., & Goda, T. (2009) · Nutrition · doi:10.1016/j.nut.2009.02.012 · Cited by 57
Glycyrrhiza glabra L.
Bielenberg, J. (2009) · Zeitschrift für Phytotherapie · doi:10.1055/s-0029-1242929 · Cited by 56
Curcumin (Diferuloylmethane) Inhibits Cell Proliferation, Induces Apoptosis, and Decreases Hormone Levels and Secretion in Pituitary Tumor Cells
Miller, M. R., Chen, S., Woodliff, J. E., & Kansra, S. (2008) · Endocrinology · doi:10.1210/en.2007-1760 · Cited by 56
Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation
Hu, Y., & Davies, G. E. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.03.002 · Cited by 56
Proteomic analysis for inhibitory effect of chitosan oligosaccharides on 3T3‐L1 adipocyte differentiation
Rahman, M. A., Kumar, S. G., Kim, S. W., Hwang, H. J., Baek, Y. M., Lee, S. H., Hwang, H. S., Shon, Y. H., Nam, K. S., & Yun, J. W. (2008) · PROTEOMICS · doi:10.1002/pmic.200700888 · Cited by 56
Self-citation
Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene
Oben, J. E., Ngondi, J. L., & Blum, K. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-44 · Cited by 56
The effect of caffeine on food intake in rats: Involvement of corticotropin-releasing factor and the sympatho-adrenal system
Racotta, I. S., LEBLANC, J., & Richard, D. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90196-1 · Cited by 55
Orlistat (Xenical)-induced subacute liver failure
Thurairajah, P. H., Syn, W., Neil, D., Stell, D. A., & Haydon, G. H. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000187680.53389.88 · Cited by 54
Effects of Toona Sinensis Leaf Extract on Lipolysis in Differentiated 3T3‐L1 Adipocytes
Hsu, H., Yang, Y., Hwang, J., & Hong, S. (2003) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/s1607-551x(09)70481-4 · Cited by 54
Panclicins, novel pancreatic lipase inhibitors. I. Taxonomy, fermentation, isolation and biological activity.
Mutoh, M., Nakada, N., Matsukuma, S., Ohshima, S., Yoshinri, K., Watanabe, J. A., & Arisawa, M. (1994) · The Journal of Antibiotics · doi:10.7164/antibiotics.47.1369 · Cited by 54
In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects.
Ho, S.-C., Tai, E. S., Eng, P., Tan, C., & Fok, A. C. K. (2001) · PubMed · Cited by 52
Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice
Park, S. H., Lee, S. G., Kang, S. K., & Chung, S. H. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02974078 · Cited by 52
Effect of Zizyphus jujuba Extract on the Inhibition of Adipogenesis in 3T3-L1 Preadipocytes
Kubota, H., Morii, R., Kojima‐Yuasa, A., Huang, X., Yano, Y., & Matsui‐Yuasa, I. (2009) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x09007089 · Cited by 51
Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway
Park (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000174 · Cited by 49
Screening of Korean medicinal plants for lipase inhibitory activity
Kim, H. Y., & Kang, M. H. (2005) · Phytotherapy Research · doi:10.1002/ptr.1592 · Cited by 48
Inhibitory Effect of Deep-sea Water on Differentiation of 3T3-L1 Adipocytes
Hwang, H. S., Kim, S. H., Yoo, Y. G., Chu, Y. S., Shon, Y. H., Nam, K. S., & Yun, J. W. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9131-8 · Cited by 48
Self-citation
Xanthohumol Influences Preadipocyte Differentiation: Implication of Antiproliferative and Apoptotic Effects
Mendes, V., Monteiro, R., Pestana, D., Teixeira, D., Calhau, C., & Azevedo, I. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802233q · Cited by 47
The Ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions
Kim, E.-J., Lee, H. I., Chung, K.-J., Noh, Y., Ro, Y., & Koo, J.-H. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.4.194 · Cited by 47
Effect of sterols and fatty acids on growth and triglyceride accumulation in 3T3-L1 cells
Awad, A. B., Begdache, L. A., & Fink, C. S. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00087-x · Cited by 45
Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes.
Zong, W., & Zhao, G. (2007) · PubMed · Cited by 43
Anti-Obesity Effects of Natural Products
Hanl, K., Kimura, Y., & Okuda, H. (2005) · Studies in natural products chemistry · doi:10.1016/s1572-5995(05)80031-6 · Cited by 42
Shikonin inhibits fat accumulation in 3T3‐L1 adipocytes
Lee, H., Kang, R., & Yoon, Y. (2009) · Phytotherapy Research · doi:10.1002/ptr.2942 · Cited by 42
Antiobesity properties of two African plants (Afromomum meleguetta and Spilanthes acmella) by pancreatic lipase inhibition
Ekanem, A. P., Wang, M., Simon, J. E., & Moreno, D. A. (2007) · Phytotherapy Research · doi:10.1002/ptr.2239 · Cited by 42
Reduction of fat storage in mice fed a high‐fat diet long term by treatment with saponins prepared fromKochia scopariafruit
Han, L., Nose, R., Li, W., Gong, X., Zheng, Y., Yoshikawa, M., Koike, K., Nikaido, T., Okuda, H., & Kimura, Y. (2006) · Phytotherapy Research · doi:10.1002/ptr.1981 · Cited by 42
Sibutramine and the management of obesity
Poston, W. S. C., & Foreyt, J. P. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.3.633 · Cited by 41
Effects of Pine Needle Extract on Differentiation of 3T3-L1 Preadipocytes and Obesity in High-Fat Diet Fed Rats
Jeon, J.-R., & Kim, J. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2111 · Cited by 41
Baicalein Inhibits Adipocyte Differentiation by Enhancing COX-2 Expression
Ho, M., Kim, I., Lee, B., & Yoon, Y. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.145 · Cited by 40
Effect of some phytoestrogens on metabolism of rat adipocytes
Szkudelska, K., Nogowski, L., & Szkudelski, T. (1999) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19990408 · Cited by 39
Effects ofin vitro-Digested Ginsenosides on Lipid Accumulation in 3T3-L1 Adipocytes
Kim, S., Lee, J., Shin, H., Son, S., & Kim, Y. S. (2009) · Planta Medica · doi:10.1055/s-0029-1185358 · Cited by 36
Oral oleoyl-estrone induces the rapid loss of body fat in Zucker lean rats fed a hyperlipidic diet
Remesar, X., Guijarro, P., Torregrosa, C. J., Grasa, M., López, J., Fernández–Löpez, J., & Alemany, M. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801393 · Cited by 36
Sibutramine: Balancing weight loss benefit and possible cardiovascular risk
SIMONE, G. D., & D’Addeo, G. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.03.008 · Cited by 36
Suppressive effect of hot water extract of wasabi (Wasabia japonica Matsum.) leaves on the differentiation of 3T3-L1 preadipocytes
Ogawa, T., Tabata, H., Katsube, T., Ohta, Y., Yamasaki, Y., Yamasaki, M., & Shiwaku, K. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.04.113 · Cited by 35
Uncoupled protein 3 and p38 signal pathways are involved in anti-obesity activity of Solanum tuberosum L. cv. Bora Valley
Yoon, S.-S., Rhee, Y., Lee, H., Lee, E., Lee, M., Ahn, K.-S., Lim, H., & Kim, S. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.05.014 · Cited by 32
Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation.
YOSHINARI, K., Aoki, M., Ohtsuka, T., NAKAYAMA, N., Itezono, Y., Mutoh, M., Watanabe, J. A., & Yokose, K. (1994) · The Journal of Antibiotics · doi:10.7164/antibiotics.47.1376 · Cited by 32
Effect of orally and intraperitoneally administered plant lectins on food consumption of rats
Baintner, K., Kiss, P., Pfüller, U., Bardócz, S., & Pusztai, A. J. (2003) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.90.2003.2.2 · Cited by 31
Differences in Basal Energy Expenditure and Obesity
Flatt, J. P. (2007) · Obesity · doi:10.1038/oby.2007.304 · Cited by 30
Medium‐Chain Fatty Acids Attenuate Agonist‐Stimulated Lipolysis, Mimicking the Effects of Starvation
Lei, T., Xie, W., Han, J., Corkey, B. E., Hamilton, J. A., & Guo, W. (2004) · Obesity Research · doi:10.1038/oby.2004.69 · Cited by 29
Indigenous Use of Hoodia gordonii and Appetite Suppression
Lee, R. A., & Balick, M. J. (2007) · EXPLORE · doi:10.1016/j.explore.2007.05.005 · Cited by 29
Screening of wood damaging fungi and macrofungi for inhibitors of pancreatic lipase
Slanc, P., Doljak, B., Mlinarič, A., & Štrukelj, B. (2004) · Phytotherapy Research · doi:10.1002/ptr.1548 · Cited by 29
Down-regulation of PPARγ2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis
Moon, H. S., Lee, H. G., Seo, J., Chung, C. S., Kim, T. G., Kim, I. Y., Lim, K. W., Seo, S., Choi, Y.-J., & Cho, C. S. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.10.002 · Cited by 29
Microbial metabolites with inhibitory activity against lipid metabolism
Tomoda, H., Namatame, I., & Ōmura, S. (2002) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.78.217 · Cited by 29
The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR-α and Adipocyte PPAR-γ Gene Expressions
Matsuo, K., Arai, H., Muto, K., Fukaya, M., Sato, T., Mizuno, A., Sakuma, M., Yamanaka‐Okumura, H., Sasaki, H., Yamamoto, H., et al. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.40.234 · Cited by 29
Rehmannia inhibits adipocyte differentiation and adipogenesis
Lin, J., Zhang, N.-X., Mo, W., Rui, W., Ma, C.-G., Li, X., Gu, Y.-L., Yang, X.-Y., Tang, Q.-Q., & Song, H.-Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.129 · Cited by 28
The effect of salatrim, a low-calorie modified triacylglycerol, on appetite and energy intake
Sørensen, L. B., Cueto, H. T., Andersen, M. T., Bitz, C., Holst, J. J., Rehfeld, J. F., & Astrup, A. V. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1163 · Cited by 28
Acanthopanax senticosus Extract Prepared from Cultured Cells Decreases Adiposity and Obesity Indices in C57BL/6J Mice Fed a High Fat Diet
Cha, Y., Rhee, S., & Heo, Y. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.422 · Cited by 26
Altered mRNA expression of hepatic lipogenic enzyme and PPARα in rats fed dietary levan from Zymomonas mobilis
Kang, S. A., Hong, K.-H., Jang, K., Kim, Y., Choue, R., & Lim, Y. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.08.012 · Cited by 26
Activity of two different polyglucosamines, L112® and FF45®, on body weight in male rats
Bondiolotti, G., Bareggi, S. R., Frega, N. G., Strabioli, S., & Cornelli, U. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.054 · Cited by 25
Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity
Abidov, M. T., del Rio, M. J., Ramazanov, T. Z., Klimenov, A. L., Dzhamirze, S., & Kalyuzhin, O. V. (2006) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-006-0167-3 · Cited by 25
Consumption of Dietary Supplements Containing Citrus aurantium (Bitter Orange)—2004 California Behavioral Risk Factor Surveillance Survey (BRFSS)
Klontz, K. C., Timbo, B. B., & Street, D. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1h196 · Cited by 25
(−)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells
Ito, M., Itô, J., Kitazawa, H., Shimamura, K., Fukami, T., Tokita, S., Shimokawa, K., Yamada, K., Kanatani, A., & Uemura, D. (2009) · Peptides · doi:10.1016/j.peptides.2009.02.008 · Cited by 25
An aqueous extract of Salacia oblonga root, a herb-derived peroxisome proliferator-activated receptor-alpha activator, by oral gavage over 28 days induces gender-dependent hepatic hypertrophy in rats
Rong, X., Kim, M. S., Su, N., Wen, S., Matsuo, Y., Yamahara, J., Murray, M. T., & Li, Y. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.02.022 · Cited by 25
Suppression of adipocyte differentiation byCordyceps militaristhrough activation of the aryl hydrocarbon receptor
Shimada, T., Hiramatsu, N., Kasai, A., Mukai, M., Okamura, M., Yao, J. Q., Huang, T., Tamai, M., Takahashi, S., Nakamura, T., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90373.2008 · Cited by 25
The effect of sibutramine therapy on occurrence of depression symptoms among obese patients
Slováček, L., Pavlík, V., & Slováčková, B. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.04.002 · Cited by 24
The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity
Tominaga, S., Sugahara, T., Nishimoto, S., Yamawaki, M., NAKASHIMA, Y., Kishida, T., Akiyama, K., Maruyama, M., & Yamauchi, S. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80393 · Cited by 24
Effects of Mannooligosaccharides from Coffee Mannan on Fat Storage in Mice Fed a High Fat Diet
Takao, I., FUJII, S., Ishii, A., Han, L.-K., Kumao, T., Ozaki, K., & Asakawa, A. (2006) · Eisei kagaku · doi:10.1248/jhs.52.333 · Cited by 24
Inhibitory effect of Eucommia ulmoides Oliver on adipogenic differentiation through proteome analysis
Lee, G. W., Yoon, H. C., & Byun, S. Y. (2004) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2004.08.037 · Cited by 23
Oleoyl-estrone treatment activates apoptotic mechanisms in white adipose tissue
Salas, A., Remesar, X., & Esteve, M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.09.025 · Cited by 20
The Differentiation- and Proliferation-Inhibitory Effects of Sporamin from Sweet Potato in 3T3-L1 Preadipocytes
XIONG, Z.-D., Li, P.-G., & Mu, T. (2009) · Agricultural Sciences in China · doi:10.1016/s1671-2927(08)60263-1 · Cited by 19
Antiobesity Effects ofIsaria sinclairiiby Repeated Oral Treatment in Obese Zucker Rats Over a 4-Month Period∗
Ahn, M. Y., Jee, S. D., & Lee, B. M. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701428556 · Cited by 16
The Effect of Ephedra and High Fat Dieting: A Cause for Concern!
Fleming, R. M. (2007) · Angiology · doi:10.1177/0003319706297965 · Cited by 14
Effect of trans8, cis10+cis9, trans11 Conjugated Linoleic Acid Mixture on Lipid Metabolism in 3T3‐L1 Cells
Joseph, S. V., Miller, J. R., McLeod, R. S., & Jacques, H. (2009) · Lipids · doi:10.1007/s11745-009-3309-3 · Cited by 9
Proteome analysis for 3T3-L1 adipocyte differentiation.
Atiar Rahman, M., Kumar, S. G., Sh, L., Hwang, H. S., Kim, H. A., & Yun, J. W. (2008) · PubMed · Cited by 9
Self-citation
The Differentiation- and Proliferation-Inhibitory Effects of Sporamin from Sweet Potato in 3T3-L1 Preadipocytes
Xiong, Zhi-Dong, Li, PengGao, Mu, & Tai-hua (2009) · Journal of Integrative Agriculture · Cited by 9
Effects of Combined Oleoyl-Estrone and Rimonabant on Overweight Rats
Ferrer‐Lorente, R., Cabot, C., Fernández–Löpez, J., & Alemany, M. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0061441 · Cited by 7
The conjugated linoleic acid ester of estrone induces the mobilisation of fat in male Wistar rats
Romero, M. D. M., Esteve, M., Fernández–Löpez, J., & Alemany, M. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0148-8 · Cited by 6
Differential Effects of Chitooligosaccharides on Serum Cytokine Levels in Aged Subjects
Kim, H.-M., Hong, S.-H., Yoo, S., Baek, K. S., Jeon, Y.-J., & Choung, S. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.427 · Cited by 3
Rubus idaeus, raspberry
Tobyn, G., Denham, A. E., & Whitelegg, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-10344-5.00031-8 · Cited by 3

Sorted by citations

Extraction and quantification of saponins: A review
Cheok, C. Y., Salman, H. A. K., & Sulaiman, R. (2014) · Food Research International · doi:10.1016/j.foodres.2014.01.057 · Cited by 450
Limonene: Aroma of innovation in health and disease
Vieira, A. J., Beserra, F. P., de Souza, M. C., Totti, B. M., & Rozza, A. L. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.007 · Cited by 388
Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity
Marrelli, M., Conforti, F., Araniti, F., & Statti, G. A. (2016) · Molecules · doi:10.3390/molecules21101404 · Cited by 310
Effects of extraction solvents on total phenolic and flavonoid contents and biological activities of extracts from Sudanese medicinal plants
Dirar, A. I., Alsaadi, D. H. M., Wada, M., Mohamed, M. A., Watanabe, T., & Devkota, H. P. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.07.003 · Cited by 270
In Vitro Inhibitory Effect on Digestive Enzymes and Antioxidant Potential of Commonly Consumed Fruits
Podsędek, A., Majewska, I., Redzynia, M., Sosnowska, D., & Koziołkiewicz, M. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5008264 · Cited by 267

See all 624

Authors: Yun, J. W.
Affiliations: Daegu University (KR)
Corresponding author: Yun, Jong Won
ORCID: Yun, Jong Won
Venue: Phytochemistry
Publisher: Elsevier BV
Published: 2010-10
Volume: 71
Issue: 14-15
Pages: 1625-1641
ISSN: 0031-9422 (ISSN-L)
DOI: 10.1016/j.phytochem.2010.07.011
OpenAlex: W2167277714
Cited by: 619
References: 294
Citations by year: 2026: 7 · 2025: 21 · 2024: 25 · 2023: 29 · 2022: 50 · 2021: 40 · 2020: 37 · 2019: 55 · 2018: 57 · 2017: 49 · 2016: 64 · 2015: 50 · 2014: 47 · 2013: 37 · 2012: 36
FWCI: 3.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Phytochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: obesity, anti-obesity drugs, natural products, orlistat, sibutramine, pancreatic lipase inhibition, appetite suppressants, mechanism of action, obesity-related comorbidities
MeSH terms: Appetite Depressants, Biological Products, Energy Metabolism, Lipase, Obesity, Plants, Medicinal, Adipocytes, Anti-Obesity Agents, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Possible anti-obesity therapeutics from nature--a review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks