Possible anti-obesity therapeutics from nature--a review

Brown Adipose Tissue: Function and Physiological Significance

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Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

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AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

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Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans

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New developments in adipogenesis

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Pancreatic lipase inhibitors from natural sources: Unexplored potential

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Dietary Cyanidin 3-O-β-D-Glucoside-Rich Purple Corn Color Prevents Obesity and Ameliorates Hyperglycemia in Mice

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Regulation of Adipocyte Development

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Malonyl-CoA, fuel sensing, and insulin resistance

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Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues

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Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

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Antidiabetic Effects of Panax ginseng Berry Extract and the Identification of an Effective Component

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Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate

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Inhibitory Effects of Oolong Tea Polyphenols on Pancreatic Lipase in Vitro

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Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

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Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase

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Appetite control

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Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men

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Phytochemicals and regulation of the adipocyte life cycle

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Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

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Anti‐obesity effects of green tea: From bedside to bench

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Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce β-oxidation in white fat

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Medium chain fatty acid metabolism and energy expenditure: obesity treatment implications.

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The potential role of green tea catechins in the prevention of the metabolic syndrome – A review

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Fish Oil Feeding Decreases Mature Sterol Regulatory Element-binding Protein 1 (SREBP-1) by Down-regulation of SREBP-1c mRNA in Mouse Liver

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Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity

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Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome

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Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin

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Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent

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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.

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Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats

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Oleoylethanolamide Stimulates Lipolysis by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor α (PPAR-α)

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Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-Ay Mice

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Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice

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Conjugated linoleic acid and obesity control: efficacy and mechanisms

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Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity

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Mechanisms of hypolipidemic and anti‐obesity effects of tea and tea polyphenols

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Orlistat: its current status as an anti-obesity drug

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Regulation of adipocyte differentiation and function by polyunsaturated fatty acids

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The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase

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Medium‐Chain Triglycerides Increase Energy Expenditure and Decrease Adiposity in Overweight Men

St‐Onge, M., Ross, R., Parsons, W. D., & Jones, P. J. H. (2003) · Obesity Research · doi:10.1038/oby.2003.53 · Cited by 280

Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice

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Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway

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Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats

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Molecular regulation of adipocyte differentiation

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Inhibitory effects of grape seed extract on lipases

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Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase

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The Soy Isoflavone Genistein Decreases Adipose Deposition in Mice

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Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis

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Anti-obesity action of oolong tea

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Dietary Curcuminoids Prevent High-Fat Diet–Induced Lipid Accumulation in Rat Liver and Epididymal Adipose Tissue

Asai, A., & Miyazawa, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.2932 · Cited by 260

Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin

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Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin

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Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice

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Carnosic acid, a new class of lipid absorption inhibitor from sage

Ninomiya, K., Matsuda, H., Shimoda, H., Nishida, N., Kasajima, N., Yoshino, T., Morikawa, T., & Yoshikawa, M. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.01.091 · Cited by 239

Saponins from Platycodi Radix Ameliorate High Fat Diet–Induced Obesity in Mice

Han, L.-K., Zheng, Y., Okuda, H., Xu, B., & Kimura, Y. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2241 · Cited by 235

Docosahexaenoic Acid Inhibits Adipocyte Differentiation and Induces Apoptosis in 3T3-L1 Preadipocytes

Kim, H., Della‐Fera, M. A., Lin, J., & Baile, C. A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.12.2965 · Cited by 234

Green Tea Polyphenol Epigallocatechin Gallate Inhibits Adipogenesis and Induces Apoptosis in 3T3‐L1 Adipocytes

Lin, J., Della‐Fera, M. A., & Baile, C. A. (2005) · Obesity Research · doi:10.1038/oby.2005.115 · Cited by 234

Rapid transformation of white adipocytes into fat-oxidizing machines

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G UGULIPID : A Natural Cholesterol-Lowering Agent

Urizar, N. L., & Moore, D. D. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073102 · Cited by 234

Salacia reticulata and Its Polyphenolic Constituents with Lipase Inhibitory and Lipolytic Activities Have Mild Antiobesity Effects in Rats

Yoshikawa, M., Shimoda, H., Matsuda, H., Nishida, N., & Takada, M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.1819 · Cited by 233

Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet

Han, L.-K., Kimura, Y., & Okuda, H. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800806 · Cited by 231

Current and investigational antiobesity agents and obesity therapeutic treatment targets

Bays, H. E. (2004) · Obesity Research · doi:10.1038/oby.2004.151 · Cited by 228 · cited 2×

Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-α

Pérez‐Matute, P., Pérez-Echarri, N., Martínez, J. A., Martí, A., & Moreno-Aliaga, M. J. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507207627 · Cited by 227

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells

Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., & Miyashita, K. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.1.147 · Cited by 226

Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat

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Effects of astaxanthin in obese mice fed a high-fat diet

IKEUCHI, M., KOYAMA, T., TAKAHASHI, J., & YAZAWA, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60521 · Cited by 222

Tannic Acid Stimulates Glucose Transport and Inhibits Adipocyte Differentiation in 3T3-L1 Cells

Liu, X., Kim, J. K., Li, Y., Li, J., Liu, F., & Chen, X. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.165 · Cited by 219

Capsaicin-Induced -Adrenergic Action on Energy Metabolism in Rats: Influence of Capsaicin on Oxygen Consumption, the Respiratory Quotient, and Substrate Utilization

Kawada, T., Watanabe, T., Takaishi, T., Tanaka, T., & Iwai, K. (1986) · Experimental Biology and Medicine · doi:10.3181/00379727-183-42414 · Cited by 214

Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK)

AOYAMA, T., Fukui, K., Takamatsu, K., Hashimoto, Y., & Yamamoto, T. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00230-6 · Cited by 213

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes

Tsuda, T., Ueno, Y., Aoki, H., Koda, T., Horio, F., Takahashi, N., Kawada, T., & Osawa, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.031 · Cited by 213

Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ.

Cinti, S. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344046 · Cited by 213

Effects of Capsaicin on Induction of Apoptosis and Inhibition of Adipogenesis in 3T3-L1 Cells

Hsu, C., & Yen, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062912b · Cited by 210

Phenolic compounds: Evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms

Hsu, C., & Yen, G. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700393 · Cited by 210

Antidiabetes and Anti‐Obesity Activity of Lagerstroemia speciosa

Klein, G., Kim, J. K., Himmeldirk, K. B., Cao, Y., & Chen, X. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem013 · Cited by 209

Soybean β-Conglycinin Diet Suppresses Serum Triglyceride Levels in Normal and Genetically Obese Mice by Induction of β-Oxidation, Downregulation of Fatty Acid Synthase, and Inhibition of Triglyceride Absorption

Moriyama, T., KISHIMOTO, K., Nagai, K., Urade, R., Ogawa, T., Utsumi, S., Maruyama, N., & Maebuchi, M. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.352 · Cited by 208

Genistein Decreases Food Intake, Body Weight, and Fat Pad Weight and Causes Adipose Tissue Apoptosis in Ovariectomized Female Mice

Kim, H.-K., Nelson-Dooley, C., Della-Fera, M. A., Yang, J.-Y., Zhang, W., Duan, J., Hartzell, D. L., Hamrick, M. W., & Baile, C. A. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.2.409 · Cited by 206

Curcumin Exerts Antidifferentiation Effect through AMPKα-PPAR-γ in 3T3-L1 Adipocytes and Antiproliferatory Effect through AMPKα-COX-2 in Cancer Cells

Lee, Y. K., Lee, W. S., Hwang, J. T., Kwon, D. Y., Surh, Y. J., & Park, O. J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802737z · Cited by 204

Hesperidin as an Inhibitor of Lipases from Porcine Pancreas andPseudomonas

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Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator‐Activated Receptors

Sheng, X., Zhang, Y., Gong, Z., Huang, C., & Zang, Y. Q. (2008) · PPAR Research · doi:10.1155/2008/581348 · Cited by 203

Platycodi Radix Affects Lipid Metabolism in Mice with High Fat Diet–Induced Obesity

Li-kun, H., Kimura, Y., Okuda, H., Xu, B., & Zheng, Y. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2760 · Cited by 201

Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3‐L1 preadipocytes

Evans, M., Geigerman, C., Cook, J., Curtis, L., Kuebler, B., & McIntosh, M. (2000) · Lipids · doi:10.1007/s11745-000-0599-6 · Cited by 201

An Extract of Lagerstroemia speciosa L. Has Insulin-Like Glucose Uptake–Stimulatory and Adipocyte Differentiation–Inhibitory Activities in 3T3-L1 Cells

Liu, F., Kim, J.-K., Li, Y., Liu, X.-Q., Li, J., & Chen, X. (2001) · Journal of Nutrition · doi:10.1093/jn/131.9.2242 · Cited by 197

Anti-obesity Effect ofDioscorea nipponicaMakino with Lipase-inhibitory Activity in Rodents

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The Effects of Epigallocatechin-3-Gallate on Thermogenesis and Fat Oxidation in Obese Men: A Pilot Study

Boschmann, M., & Thielecke, F. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719627 · Cited by 194

Differential effects of central fructose and glucose on hypothalamic malonyl–CoA and food intake

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Overfeeding with medium-chain triglyceride diet results in diminished deposition of fat

Geliebter, A., Torbay, N., Bracco, E., Hashim, S., & Itallie, T. V. (1983) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.1.1 · Cited by 190

Vibralactone: A Lipase Inhibitor with an Unusual Fused β-Lactone Produced by Cultures of the Basidiomycete Boreostereum vibrans

Liu, D., Wang, F., Liao, T., Tang, J., Steglich, W., Zhu, H., & Liu, J. (2006) · Organic Letters · doi:10.1021/ol062307u · Cited by 189

Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR‐γ signal pathways

Hwang, J., Lee, M., Kim, H., Sung, M., Kim, H. Y., Kim, M., & Kwon, D. Y. (2008) · Phytotherapy Research · doi:10.1002/ptr.2606 · Cited by 185

Anti-hyperglycemic effects of ginseng: Comparison between root and berry

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