Plant lectins as defense proteins against phytophagous insects

The Myriad Plant Responses to Herbivores

Walling, L. L. (2000) · Journal of Plant Growth Regulation · doi:10.1007/s003440000026 · Cited by 1,386

Lectins as Plant Defense Proteins

Peumans, W. J., & Van Damme, E. (1995) · Plant Physiology · doi:10.1104/pp.109.2.347 · Cited by 1,160

Cross Talk in Defense Signaling

Koornneef, A., & Pieterse, C. M. J. (2008) · Plant Physiology · doi:10.1104/pp.107.112029 · Cited by 1,022

Signal Signature and Transcriptome Changes of Arabidopsis During Pathogen and Insect Attack

De Vos, M., Van Oosten, V. R., Van Poecke, R. M. P., Van Pelt, J. A., Pozo, M. J., Mueller, M. J., Buchala, A. J., Métraux, J.-P., Van Loon, L. C., Dicke, M., et al. (2005) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi-18-0923 · Cited by 974

Plant Lectins: A Composite of Several Distinct Families of Structurally and Evolutionary Related Proteins with Diverse Biological Roles

Van Damme, E. (1998) · Critical Reviews in Plant Sciences · doi:10.1016/s0735-2689(98)00365-7 · Cited by 705

New Insights into Peritrophic Matrix Synthesis, Architecture, and Function

Hegedus, D., Erlandson, M., Gillott, C., & Toprak, U. (2009) · Annual Review of Entomology · doi:10.1146/annurev.ento.54.110807.090559 · Cited by 658

Avoiding Effective Defenses: Strategies Employed by Phloem-Feeding Insects

Walling, L. L. (2008) · Plant Physiology · doi:10.1104/pp.107.113142 · Cited by 616

Molecular Responses to Aphid Feeding in Arabidopsis in Relation to Plant Defense Pathways

Moran, P. J., & Thompson, G. A. (2001) · Plant Physiology · doi:10.1104/pp.125.2.1074 · Cited by 595

Antifungal Proteins

Selitrennikoff, C. P. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2883-2894.2001 · Cited by 503

Insect chitin synthases: a review

Merzendorfer, H. (2006) · Journal of Comparative Physiology B · doi:10.1007/s00360-005-0005-3 · Cited by 494

Induced Plant Resistance to Herbivory

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Inducible direct plant defense against insect herbivores: A review

Chen, M. (2008) · Insect Science · doi:10.1111/j.1744-7917.2008.00190.x · Cited by 445

Antinutritional properties of plant lectins

Vasconcelos, I. M., & Oliveira, J. T. A. (2004) · Toxicon · doi:10.1016/j.toxicon.2004.05.005 · Cited by 387

Lectins as Bioactive Plant Proteins: A Potential in Cancer Treatment

De Mejía, E. G., & Prisecaru, V. I. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390591034445 · Cited by 347

Handbook of plant lectins : properties and biomedical applications

Damme, E. J. M. V. (1998) · Cited by 313

Getting In and Out from Calnexin/Calreticulin Cycles

Caramelo, J. J., & Parodi, A. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700048200 · Cited by 307

Characterization of a rice gene showing organ-specific expression in response to salt stress and drought.

Claes, B., Dekeyser, R., Villarroel, R., Van den Bulcke, M., Bauw, G., Van Montagu, M., & Caplan, A. (1990) · The Plant Cell · doi:10.1105/tpc.2.1.19 · Cited by 293

Recent developments and future prospects in insect pest control in transgenic crops

Christou, P., Capell, T., Kohli, A., Gatehouse, J. A., & Gatehouse, A. M. R. (2006) · Trends in Plant Science · doi:10.1016/j.tplants.2006.04.001 · Cited by 289

Integration of Insect-Resistant Genetically Modified Crops within IPM Programs

Kennedy, G. G. (2008) · Integration of Insect-Resistant Genetically Modified Crops within IPM Programs · doi:10.1007/978-1-4020-8373-0_1 · Cited by 288

Regulation of Midgut Growth, Development, and Metamorphosis

Hakim, R. S., Baldwin, K., & Smagghe, G. (2010) · Annual Review of Entomology · doi:10.1146/annurev-ento-112408-085450 · Cited by 279

Thermodynamics of Lectin-Carbohydrate Interactions. Titration Microcalorimetry Measurements of the Binding of N-Linked Carbohydrates and Ovalbumin to Concanavalin A

Mandal, D. K., Kishore, N., & Brewer, C. F. (1994) · Biochemistry · doi:10.1021/bi00171a014 · Cited by 273

Dynamic Developmental Elaboration of N-Linked Glycan Complexity in the Drosophila melanogaster Embryo

Aoki, K., Perlman, M., Lim, J.-M., Cantu, R., Wells, L., & Tiemeyer, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606711200 · Cited by 265

Plant Lectins

Van Damme, E. J. M., Lannoo, N., & Peumans, W. J. (2008) · Advances in Botanical Research · doi:10.1016/s0065-2296(08)00403-5 · Cited by 237

Plant lectins: the ties that bind in root symbiosis and plant defense

De Hoff, P. L., Brill, L. M., & Hirsch, A. M. (2009) · Molecular Genetics and Genomics · doi:10.1007/s00438-009-0460-8 · Cited by 231

Diversity of the Superfamily of Phloem Lectins (Phloem Protein 2) in Angiosperms

Dinant, S., Clark, A. M., Zhu, Y., Vilaine, F., Palauqui, J.-C., Kusiak, C., & Thompson, G. A. (2003) · Plant Physiology · doi:10.1104/pp.013086 · Cited by 227

Structural Basis of Multivalent Binding to Wheat Germ Agglutinin

Schwefel, D., Maierhofer, C., Beck, J. G., Seeberger, S., Diederichs, K., Möller, H. M., Welte, W., & Wittmann, V. (2010) · Journal of the American Chemical Society · doi:10.1021/ja101646k · Cited by 215

Expression of the insecticidal lectin from snowdrop (Galanthus nivalis agglutinin; GNA) in transgenic wheat plants: effects on predation by the grain aphid Sitobion avenae

Stoger, E., Williams, S., Christou, P., Down, R. E., & Gatehouse, J. A. (1999) · Molecular Breeding · doi:10.1023/a:1009616413886 · Cited by 210

Immunohistochemical and developmental studies to elucidate the mechanism of action of the snowdrop lectin on the rice brown planthopper, Nilaparvata lugens (Stal).

Powell, K. S., Spence, J., Bharathi, M., Gatehouse, J. A., & Gatehouse, A. M. R. (1998) · Journal of Insect Physiology · doi:10.1016/s0022-1910(98)00054-7 · Cited by 188

Cloning and Expression

Aftab, M. N. (2011) · Cited by 179

Tri-trophic interactions involving pest aphids, predatory 2-spot ladybirds and transgenic potatoes expressing snowdrop lectin for aphid resistance

Birch, A. N. E., Geoghegan, I. E., Majerus, M. E. N., McNicol, J. W., Hackett, C. A., Gatehouse, A. M. R., & Gatehouse, J. A. (1999) · Molecular Breeding · doi:10.1023/a:1009659316170 · Cited by 165

Evolutionary history and stress regulation of the lectin superfamily in higher plants

Jiang, S.-Y., Ma, Z., & Ramachandran, S. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-79 · Cited by 160

Stability of Plant Defense Proteins in the Gut of Insect Herbivores

Chen, H., Gonzales-Vigil, E., Wilkerson, C. G., & Howe, G. A. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.095588 · Cited by 159

Hevein, a lectin-like protein from Hevea brasiliensis (rubber tree) is involved in the coagulation of latex.

Gidrol, X., Chrestin, H., Tan, H., & Kush, A. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37104-1 · Cited by 155

The evolution of N-glycan-dependent endoplasmic reticulum quality control factors for glycoprotein folding and degradation

Banerjee, S., Vishwanath, P., Cui, J., Kelleher, D. J., Gilmore, R., Robbins, P. W., & Samuelson, J. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704862104 · Cited by 151

Proteins with antifungal properties and other medicinal applications from plants and mushrooms

Wong, J. H., Ng, T. B., Cheung, R. C. F., Ye, X. J., Wang, H. X., Lam, S. K., Lin, P., Chan, Y. S., Fang, E. F., Ngai, P. H. K., et al. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2690-4 · Cited by 151

Plant‐insect interactions: what can we learn from plant lectins?

Michiels, K., Damme, E. J. M. V., & Smagghe, G. J. (2010) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.20351 · Cited by 135

Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins

Pusztai, A. J., Ewen, S. W. B., Grant, G., Brown, D. S., Stewart, J. C., Peumans, W. J., Damme, E. J. M. V., & Bardócz, S. (1993) · British Journal Of Nutrition · doi:10.1079/bjn19930124 · Cited by 130

Lectinomics

Gemeiner, P., Mislovičová, D., Tkáč, J., Švitel, J., Pätoprstý, V., Hrabárová, E., Kogan, G., & Kožár, T. (2008) · Biotechnology Advances · doi:10.1016/j.biotechadv.2008.07.003 · Cited by 129

Nucleocytoplasmic plant lectins

Lannoo, N., & Damme, E. J. M. V. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.021 · Cited by 124

Binding Properties of the N-Acetylglucosamine and High-Mannose N-Glycan PP2-A1 Phloem Lectin in Arabidopsis

Bénéteau, J., Renard, D., Marché, L., Douville, É., Lavenant, L., Rahbé, Y., Dupont, D., Vilaine, F., & Dinant, S. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.153882 · Cited by 104

Structural insights into what glycan arrays tell us about how glycan-binding proteins interact with their ligands

Taylor, M. E., & Drickamer, K. (2009) · Glycobiology · doi:10.1093/glycob/cwp076 · Cited by 97

A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA)

Poulsen, M., Kroghsbo, S., Schrøder, M., Wilcks, A., Jacobsen, H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., et al. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.09.002 · Cited by 93

Potential of carbohydrate‐binding agents as therapeutics against enveloped viruses

François, K. O., & Balzarini, J. M. (2010) · Medicinal Research Reviews · doi:10.1002/med.20216 · Cited by 90

Enhancement of resistance to aphids by introducing the snowdrop lectin genegna into maize plants

Wang, Z., Zhang, K., Sun, X., et al. (2005) · Journal of Biosciences · doi:10.1007/bf02703563 · Cited by 84

Diversity in Protein Glycosylation among Insect Species

Vandenborre, G., Smagghe, G. J., Ghesquière, B., Menschaert, G., Rao, R. N., Gevaert, K., & Damme, E. J. M. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016682 · Cited by 84

The effect of snowdrop lectin (GNA) delivered via artificial diet and transgenic plants on Eulophus pennicornis (Hymenoptera: Eulophidae), a parasitoid of the tomato moth Lacanobia oleracea (Lepidoptera: Noctuidae)

Bell, H. A., Fitches, E., Down, R. E., Marris, G. C., Edwards, J., Gatehouse, J. A., & Gatehouse, A. M. R. (1999) · Journal of Insect Physiology · doi:10.1016/s0022-1910(99)00077-3 · Cited by 75

Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent

Huskens, D., Vermeire, K., Vandemeulebroucke, E., Balzarini, J. M., & Schols, D. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.023 · Cited by 73

Direct and indirect sublethal effects of Galanthus nivalis agglutinin (GNA) on the development of a potato-aphid parasitoid, Aphelinus abdominalis (Hymenoptera: Aphelinidae)

Couty, A., de la Viña, G., Clark, S. J., Kaiser, L., Pham-Delègue, M. H., & Poppy, G. M. (2001) · Journal of Insect Physiology · doi:10.1016/s0022-1910(00)00148-7 · Cited by 68

An acoustic postconflict display in the duetting tropical boubou (Laniarius aethiopicus): a signal of victory?

Grafe, T. U., & Bitz, J. H. (2004) · BMC Ecology · doi:10.1186/1472-6785-4-1 · Cited by 67

Evaluation of the ability of lectin from snowdrop (Galanthus nivalis) to protect plants against root-knot nematodes

Ripoll, C., Favery, B., Lecomte, P., Damme, E. J. M. V., Peumans, W. J., Abad, P., & Jouanin, L. (2003) · Plant Science · doi:10.1016/s0168-9452(02)00448-x · Cited by 65

Beyond Bt: Alternative Strategies for Insect-Resistant Genetically Modified Crops

Malone, L. A., Gatehouse, A. M. R., & Barratt, B. I. P. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8373-0_13 · Cited by 64

Consumption of snowdrop lectin (Galanthus nivalis agglutinin) causes direct effects on adult parasitic wasps

Romeis, J., Babendreier, D., & WÄCKERS, F. L. (2003) · Oecologia · doi:10.1007/s00442-002-1144-9 · Cited by 63

Localization and in vitro binding studies suggest that the cytoplasmic/nuclear tobacco lectin can interact in situ with high‐mannose and complex N‐glycans

Lannoo, N., Peumans, W. J., Pamel, E. V., Alvarez, R., Xiong, T. C., Hause, G., Mazars, C., & Damme, E. J. M. V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.10.044 · Cited by 62

Transgenic GNA Expressing Potato Plants Augment the Beneficial Biocontrol of Lacanobia Oleracea (Lepidoptera: Noctuidae) by the parasitoid Eulophus Pennicornis (Hymenoptera; Eulophidae)

Bell, H. A., Fitches, E., Marris, G. C., Bell, J., Edwards, J., Gatehouse, J. A., & Gatehouse, A. M. R. (2001) · Transgenic Research · doi:10.1023/a:1008923103515 · Cited by 61

Tannins, Trypsin Inhibitors and Lectin Cytotoxicity in Tepary (Phaseolus acutifolius) and Common (Phaseolus vulgaris) Beans

de Mejı́a, E. G., Valadez-Vega, M. D. C., Reynoso‐Camacho, R., & Loarca-Piña, G. F. (2005) · Plant Foods for Human Nutrition · doi:10.1007/s11130-005-6842-0 · Cited by 60

Safety testing of GM-rice expressing PHA-E lectin using a new animal test design

Poulsen, M., Schrøder, M., Wilcks, A., Kroghsbo, S., Lindecrona, R. H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., et al. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.09.003 · Cited by 58

Plant Lectins as Part of the Plant Defense System Against Insects

Damme, E. J. M. V. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8182-8_14 · Cited by 56

Enhanced Resistance to Helicoverpa zea in Tobacco Expressing an Activated Form of Maize Ribosome- Inactivating Protein

Dowd, P. F., Zuo, W., Gillikin, J. W., Johnson, E. T., & Boston, R. S. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0211433 · Cited by 54

Direct effects of snowdrop lectin (GNA) on larvae of three aphid predators and fate of GNA after ingestion

Hogervorst, P. A. M., Ferry, N., Gatehouse, A. M. R., WÄCKERS, F. L., & Romeis, J. (2006) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2006.02.011 · Cited by 52

Paucimannose N-glycans in Caenorhabditis elegans and Drosophila melanogaster

Schachter, H. (2009) · Carbohydrate Research · doi:10.1016/j.carres.2009.04.028 · Cited by 51

Tritrophic Interactions Between Transgenic Potato Expressing Snowdrop Lectin (GNA), an Aphid Pest (Peach–Potato Aphid; Myzus Persicae (Sulz.) and a Beneficial Predator (2-Spot Ladybird; Adalia Bipunctata L.)

Down, R. E., Ford, L., Woodhouse, S. D., Davison, G. M., Majerus, M. E. N., Gatehouse, J. A., & Gatehouse, A. M. R. (2003) · Transgenic Research · doi:10.1023/a:1022904805028 · Cited by 48

Interactions of concanavalin A with asparagine‐linked glycopeptides

Bhattacharyya, L., & Brewer, C. F. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14503.x · Cited by 48

Potential Effects of Oilseed Rape Expressing Oryzacystatin-1 (OC-1) and of Purified Insecticidal Proteins on Larvae of the Solitary Bee Osmia bicornis

Konrad, R., Ferry, N., Gatehouse, A. M. R., & Babendreier, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002664 · Cited by 47

Impact of insecticidal proteins expressed in transgenic plants on bumblebee microcolonies

Babendreier, D., Reichhart, B., Romeis, J., & Bigler, F. (2008) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.2007.00652.x · Cited by 45

Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity

Fouquaert, E., Smith, D. F., Peumans, W. J., Proost, P., Balzarini, J. M., Savvides, S. N., & Damme, E. J. M. V. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.048 · Cited by 43

Transformation of Tobacco with Genes Encoding Helianthus Tuberosus Agglutinin (HTA) Confers Resistance to Peach-Potato Aphid (Myzus persicae)

Chang, T., Chen, L., Chen, S., et al. (2003) · Transgenic Research · doi:10.1023/a:1025810213869 · Cited by 38

Ribosome‐inactivating lectins with polynucleotide:adenosine glycosidase activity

Battelli, M. G., Barbieri, L. L., Bolognesi, A., Buonamici, L., Valbonesi, P., Polito, L., Damme, E. J. M. V., Peumans, W. J., & Stirpe, F. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00463-8 · Cited by 38

Glycosylation Signatures in Drosophila: Fishing with Lectins

Vandenborre, G., Damme, E. J. M. V., Ghesquière, B., Menschaert, G., Hamshou, M., Rao, R. N., Gevaert, K., & Smagghe, G. J. (2010) · Journal of Proteome Research · doi:10.1021/pr1001753 · Cited by 36

Impact of snowdrop lectin (Galanthus nivalis agglutinin; GNA) on adults of the green lacewing, Chrysoperla carnea

Li, Y., & Romeis, J. (2008) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2008.10.015 · Cited by 24

How a Plant Lectin Recognizes High Mannose Oligosaccharides

Garcia‐Pino, A., Buts, L., Wyns, L., Imberty, A., & Loris, R. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.100867 · Cited by 24

Does host‐feeding on GNA‐intoxicated aphids by Aphelinus abdominalis affect their longevity and/or fecundity?

Couty, A., & Poppy, G. M. (2001) · Entomologia Experimentalis et Applicata · doi:10.1046/j.1570-7458.2001.00880.x · Cited by 23

Natural Products: Plant Lectins as Important Tools in Controlling Pest Insects

Vandenborre, G., Damme, E. J. M. V., & Smagghe, G. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-2316-2_7 · Cited by 20

Laboratory study of the effects of leek lectin (APA) in transgenic tobacco plants on the development of cotton leafworm Spodoptera littoralis (Lepidoptera: Noctuidae)

Sadeghi, A., Smagghe, G. J., JURADO-JÁCOME, E., Peumans, W. J., & Damme, E. J. M. V. (2009) · European Journal of Entomology · doi:10.14411/eje.2009.003 · Cited by 12

Plant–arthropod interactions: who is the winner?

Stahl, E., Hilfiker, O., & Reymond, P. (2018) · The Plant Journal · doi:10.1111/tpj.13773 · Cited by 164

Exposure to polyphenol-rich purple corn pericarp extract restricts fall armyworm(Spodoptera frugiperda)growth

Singh, S., & Kariyat, R. R. (2020) · Plant Signaling & Behavior · doi:10.1080/15592324.2020.1784545 · Cited by 26