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Nucleus accumbens stimulation in pathological obesity
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“In 3 studies, deep brain stimulation was used for treatment of hypothalamic obesity in 6 patients (5 patients with PWS and 1 patient with CP). Targets of deep brain stimulation included the nucleus accumbens and the lateral hypothalamic area. In the reported CP patient, nucleus accumbens deep brain stimulation led to a decrease in BMI (−8.7%) (157). No severe side effects were observed in these”
From Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity (2025) · cites this paper as [157]
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Research works printed but not linked: 19
- Weismann, 2012, Bariatric surgery for morbid obesity in craniopharyngioma, Clin Endocrinol (Oxf)
- Melega, 2012, Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model, Neurosurg Rev, 35, 37
- Tomycz, 2011, Deep brain stimulation for obesity – from theoretical foundations to designing the first human pilot study, Acta Neurochir (Wien), 153, 2293
- Benabid, 2012, New targets for DBS, Parkinsonism Relat Disord, 18, S21, 10.1016/S1353-8020(11)70009-8 · DOI
- Halpern, 2011, Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management, Acta Neurochir (Wien), 153, 2293, 10.1007/s00701-011-1166-3 · DOI
- Mantione, 2010, Neurosurgery smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report, Neurosurgery, 66, E218, 10.1227/01.NEU.0000360570.40339.64 · DOI · Paper page
- Halpern, 2008, Deep brain stimulation in the treatment of obesity, J Neurosurg, 109, 625, 10.3171/JNS/2008/109/10/0625 · DOI
- Sun, 2012, Grading refractory anorexia nervosa for surgical treatment, Stereotact Funct Neurosurg, 90, 99
- Taghva, 2012, Obesity and brain addiction circuitry: implications for deep brain stimulation, Neurosurgery, 71, 224, 10.1227/NEU.0b013e31825972ab · DOI
- Berthoud, 2006, Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance, Obesity, Suppl 5, 197S, 10.1038/oby.2006.308 · DOI · Paper page
- Teasure, 2008, Eating disorders, Medicine, 36, 430, 10.1016/j.mpmed.2008.05.003 · DOI
- Volkov, 2008, Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology, Philos Trans R Soc Lond B Biol Sci, 393, 3191, 10.1098/rstb.2008.0107 · DOI · Paper page
- Haahr, 2012, Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry, Neuroimage, 61, 884, 10.1016/j.neuroimage.2012.03.050 · DOI
- Stoeckel, 2009, Brain effective connectivity of a reward network in obese women, Res Bull, 79, 388, 10.1016/j.brainresbull.2009.05.016 · DOI
- Skorzewska, 1989, Abnormal food-seeking behavior after surgery for craniopharyngioma, Neuropsychobiology, 21, 17, 10.1159/000118545 · DOI
- Vinchon, 2009, Craniopharyngioma and hypothalamic obesity in children, Childs Nerv Syst, 25, 347, 10.1007/s00381-008-0754-x · DOI
- Simoneau-Roy, 2010, Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma, Clin Endocrinol (Oxf), 72, 364, 10.1111/j.1365-2265.2009.03639.x · DOI
- Iughetti, 2011, Obesity and craniopharyngioma, Ital J Pediatr, 37, 38, 10.1186/1824-7288-37-38 · DOI
- Goncalves-Ferreira, 2012, Deep brain stimulation for the treatment of refractory cocaine dependence, Stereotact Funct Neurosurg, 90, 90
Cited by
van Iersel, L., Brokke, K. E., Adan, R. A. H., Bulthuis, L. C. M., van den Akker, E. L. T., & van Santen, H. M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00017 · Cited by 146
Müller, H. L., Tauber, M., Lawson, E. A., Özyurt, J., Bison, B., Martinez-Barbera, J.-P., Puget, S., Merchant, T. E., & van Santen, H. M. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00351-z · Cited by 144
van Santen, H. M., & Müller, H. L. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf025 · Cited by 21
Metadata
- Authors
- Harat, M., Rudaś, M., Zieliński, P., Birska, J., & Sokal, P.
- Venue
- Neurologia i Neurochirurgia Polska
- Publisher
- VM Media Group sp. z o.o
- Published
- 2016-05
- Volume
- 50
- Issue
- 3
- Pages
- 207-210
- ISSN
- 0028-3843
- Cited by
- 65
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- CoChat. (2026). Citation check: Nucleus accumbens stimulation in pathological obesity. https://app.cochat.ai/papers/10.1016/j.pjnns.2016.01.014
- The paper
- Harat, M., Rudaś, M., Zieliński, P., Birska, J., & Sokal, P. (2016). Nucleus accumbens stimulation in pathological obesity. Neurologia i Neurochirurgia Polska. https://doi.org/10.1016/j.pjnns.2016.01.014
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.