Smoking Cessation and Weight Loss After Chronic Deep Brain Stimulation of the Nucleus Accumbens: Therapeutic and Research Implications Case Report
Abstract
OBJECTIVE: Smoking and overeating are compulsory habits that are difficult to stop. Several studies have shown involvement of the nucleus accumbens in these and other addictive behaviors. In this case report, we describe a patient who quit smoking and lost weight without any effort, and we review the underlying mechanisms of action. CLINICAL PRESENTATION: A 47-year-old woman presented with chronic treatment-refractory obsessive-compulsive disorder, nicotine dependence, and obesity. INTERVENTION: The patient was treated with deep brain stimulation of the nucleus accumbens for obsessive-compulsive disorder. Unintended, effortless, and simultaneous smoking cessation and weight loss were observed. CONCLUSION: This study supports the idea of compulsivity with common circuitry in the processing of diverse rewards and suggests that deep brain stimulation of the nucleus accumbens could be a possible treatment of patients with a dependency not responding to currently available treatments.
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One study found that DBS targeting the NAc resulted in an unintended and "effortless" smoking cessation.
“Interestingly, one of these studies found that DBS targeting the NAc resulted in an unintended and “effortless” smoking cessation [94].”
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- Authors
- Mantione, M., van de Brink, W., Schuurman, P. R., & Denys, D.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Neurosurgery
- Published
- 2010-01
- Volume
- 66
- Issue
- 1
- Pages
- E218
- ISSN
- 0148-396X (ISSN-L)
- OpenAlex
- W2074174736
- Cited by
- 194
- References
- 16
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 16 · 2017: 8 · 2016: 11 · 2015: 21 · 2014: 8 · 2013: 16 · 2012: 23
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- smoking cessation, weight loss, nucleus accumbens, deep brain stimulation, nicotine dependence, obesity, obsessive-compulsive disorder, compulsivity, addiction, reward processing
- MeSH terms
- Eating, Female, Humans, Middle Aged, Nucleus Accumbens, Obesity, Obsessive-Compulsive Disorder, Tobacco Use Disorder, Weight Loss, Smoking Cessation, Deep Brain Stimulation
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