The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.
Fetal Growth Restriction is Associated with Accelerated Telomere Shortening and Increased Expression of Cell Senescence Markers in the Placenta
Open accessAbstract
A hallmark of fetal growth restriction (FGR) is restricted placental development and insufficient nutrient supply to the fetus. It has previously been shown that activity levels of telomerase, the enzyme responsible for completing replication of telomeric DNA during cell division, is suppressed in FGR placenta samples as compared to control placenta samples from donors of the same gestational age. Here we examine whether telomere length maintenance is also compromised in FGR placenta samples. Southern analysis of telomere length for placenta and cord blood samples from 32 FGR and 36 control donors, ranging in gestational age from 37 to 40 weeks, revealed significantly shorter telomeres (P<or=0.001) in FGR placenta samples, but not cord blood samples. Furthermore, analysis of telomerase extracts, RNA and DNA placental samples from donors with and without idiopathic FGR confirmed a direct association between suppression of telomerase activity and reduced telomere length in FGR placenta. In addition, expression levels of markers of telomere-induced senescence, p21, p16 and EF-1 alpha, were significantly elevated in FGR placenta samples (P<or=0.01). These observations support a direct affect of reduced telomerase activity levels on the placental pathology associated with FGR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Telomeres from fetal growth restriction placentas are shorter and express higher levels of CDKN2A and CDKN1A protein and EEF1A1 RNA compared with placentas from normal growth fetuses265.”
From SenNet recommendations for detecting senescent cells in different tissues (2024) · cites this paper as [265]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“Telomerase activity was assessed for all extracts using the TRAP assay [11] according to manufacturers’ protocol (Chemicon), with the following exceptions.”
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Kinetics and kinematics for translational motions in microgravity during parabolic flight.
Stirling, L., Willcox, K., Ferguson, P., & Newman, D. (2009) · Aviation Space and Environmental Medicine · doi:10.3357/asem.2356.2009 · Cited by 5,455
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Self-citationINTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION
Lubchenco, L. O., Hansman, C., Dressler, M., & Boyd, E. (1963) · PEDIATRICS · doi:10.1542/peds.32.5.793 · Cited by 1,865
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., & Smith, J. R. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1063 · Cited by 1,351
Intrauterine growth restriction
Resnik, R. (2002) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(01)01780-x · Cited by 1,022
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960
Flagged first, then by citations
1 of the 21 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Bianchi, 2000, Chapter 124: intrauterine growth restriction
Cited by
Sorted by citations
SenNet recommendations for detecting senescent cells in different tissues
Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., et al. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00738-8 · Cited by 408
“Telomeres from fetal growth restriction placentas are shorter and express higher levels of CDKN2A and CDKN1A protein and EEF1A1 RNA compared with placentas from normal growth fetuses 265 .”
Placental Apoptosis in Health and Disease
Sharp, A. N., Heazell, A. E. P., Crocker, I. P., & Mor, G. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00837.x · Cited by 336
Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes
Sultana, Z., Maiti, K., Aitken, J., Morris, J., Dedman, L., & Smith, R. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12653 · Cited by 288
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length
Entringer, S., Epel, E. S., Lin, J., Buß, C., Shahbaba, B., Blackburn, E. H., Simhan, H. N., & Wadhwa, P. D. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.11.033 · Cited by 257
Joo, E. H., Kim, Y. R., Kim, N., Jung, J. E., Han, S. H., & Cho, H. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810122 · Cited by 217
The fetal programming of telomere biology hypothesis: an update
Entringer, S., de Punder, K., Buß, C., & Wadhwa, P. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0151 · Cited by 194
Maternal pre-pregnancy body mass index and newborn telomere length
Martens, D. S., Plusquin, M., Gyselaers, W., Vivo, I. D., & Nawrot, T. S. (2016) · BMC Medicine · doi:10.1186/s12916-016-0689-0 · Cited by 189
Mitochondrial – Endoplasmic reticulum interactions in the trophoblast: Stress and senescence
Burton, G. J., Yung, H. W., & Murray, A. J. (2016) · Placenta · doi:10.1016/j.placenta.2016.04.001 · Cited by 157
Biron‐Shental, T., Halevy, R. S., Sharon, Y. A. M. V., Goldberg-Bittman, L., Kidron, D., Fejgin, M. D., & Amiel, A. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.01.036 · Cited by 146
Sultana, Z., Maiti, K., Dedman, L., & Smith, R. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.567 · Cited by 155
Manna, S., McCarthy, C., & McCarthy, F. P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3095383 · Cited by 147
Sood, A., Salih, S., Roh, D. S., Lacharme‐Lora, L., Parry, M., Hardiman, B., Keehan, R., Grümmer, R., Winterhager, E., Gokhale, P. J., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.188 · Cited by 122
Entringer, S., Buß, C., & Wadhwa, P. D. (2012) · Science Signaling · doi:10.1126/scisignal.2003580 · Cited by 121
Evidence that fetal death is associated with placental aging
Maiti, K., Sultana, Z., Aitken, R. J., Morris, J. M., Park, F. J., Andrew, B., Riley, S. C., & Smith, R. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.015 · Cited by 104
Molecular pathways of senescence regulate placental structure and function
Gal, H., Lysenko, M., Stroganov, S., Vadai, E., Youssef, S. A., Geffen, K. T., Rotkopf, R., Biron‐Shental, T., de Bruin, A., Neeman, M., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100849 · Cited by 103
Bijnens, E. M., Zeegers, M. P., Gielen, M., Kiciński, M., Hageman, G. J., Pachen, D. M. F. A., Derom, C. A., VLIETINCK, R. F., & Nawrot, T. S. (2015) · Environment International · doi:10.1016/j.envint.2015.02.008 · Cited by 85
Wells, J. C. K. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9780511972959 · Cited by 83
Biron‐Shental, T., Halevy, R. S., Goldberg-Bittman, L., Kidron, D., Fejgin, M. D., & Amiel, A. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.06.002 · Cited by 72
Premature placental aging in term small‐for‐gestational‐age and growth‐restricted fetuses
Paulés, C., Dantas, A. P., Miranda, J., Crovetto, F., Eixarch, E., Rodríguez‐Sureda, V., Domínguez, C., Casu, G., Rovira, C., Nadal, A., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20103 · Cited by 73
Sultana, Z., Qiao, Y., Maiti, K., & Smith, R. (2023) · Reproduction · doi:10.1530/rep-22-0278 · Cited by 68
Perinatal Complications and Aging Indicators by Midlife
Shalev, I., Caspi, A., Ambler, A. P., Belsky, D. W., Chapple, S., Cohen, H. J., Israel, S., Poulton, R., Ramrakha, S., Rivera, C. D., et al. (2014) · PEDIATRICS · doi:10.1542/peds.2014-1669 · Cited by 66
Yu, Q., Liu, Y., Xu, L., Zheng, C., Le, F., Qin, X., Liu, Y., & Liu, J. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.05.040 · Cited by 64
Placental aging and oxidation damage in a tissue micro-array model: an immunohistochemistry study
Londero, A. P., Orsaria, M., Marzinotto, S., Grassi, T., Fruscalzo, A., Calcagno, A., Bertozzi, S., Nardini, N., Stella, E., Lellé, R. J., et al. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1435-6 · Cited by 61
Gomez‐Lopez, N., Romero, R. J., Plazyo, O., Schwenkel, G., Garcia‐Flores, V., Unkel, R., Xu, Y., Leng, Y., Hassan, S. S., Panaitescu, B., et al. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.08.008 · Cited by 62
Positive and negative effects of cellular senescence during female reproductive aging and pregnancy
Velarde, M. C., & Menon, R. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0018 · Cited by 65
Zhou, H., Zhao, C., Wang, P., Yang, W., Zhu, H., & Zhang, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1107182 · Cited by 59
Broady, A. J., Loichinger, M. H., Ahn, H. J., Davy, P. M. C., Allsopp, R., & Bryant‐Greenwood, G. D. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.018 · Cited by 58
Self-citationHalevy, R. S., Amiel, A., Kidron, D., Liberman, M., Ganor‐Paz, Y., & Biron‐Shental, T. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.050 · Cited by 56
Gielen, M., Hageman, G. J., Pachen, D. M. F. A., Derom, C. A., VLIETINCK, R. F., & Zeegers, M. P. (2014) · Placenta · doi:10.1016/j.placenta.2014.05.010 · Cited by 57
Sharma, E., Mustafa, M., Pathak, R., Guleria, K., Ahmed, R. S., Vaid, N., & Banerjee, B. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.01.008 · Cited by 56
Jones, C. W., Gambala, C. T., Esteves, K. C., Wallace, M. E., Schlesinger, R. P., O’Quinn, M., Kidd, L. R., Theall, K. P., & Drury, S. S. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.11.1027 · Cited by 55
Placental telomere shortening in stillbirth: a sign of premature senescence?
Ferrari, F., Facchinetti, F., Saade, G. R., & Menon, R. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1046045 · Cited by 54
Unexplained antepartum stillbirth: A consequence of placental aging?
Smith, R., Maiti, K., & Aitken, R. J. (2013) · Placenta · doi:10.1016/j.placenta.2013.01.015 · Cited by 52
Reduced Placental Telomere Length during Pregnancies Complicated by Intrauterine Growth Restriction
Toutain, J., Prochazkova‐Carlotti, M., Cappellen, D., Jarné, A., Chevret, E., Ferrer, J., Idrissi, Y., Pelluard, F., Carles, D., Maugey-Laulon, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054013 · Cited by 49
Pathak, R., Mustafa, M., Ahmed, T., Ahmed, R. S., Tripathi, A. K., Guleria, K., & Banerjee, B. D. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.02.007 · Cited by 49
A tale of the good and bad: Cell senescence in bone homeostasis and disease
Liu, X., & Wan, M. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.03.005 · Cited by 45
United we stand not dividing: The syncytiotrophoblast and cell senescence
Goldman-Wohl, D., & Yagel, S. (2014) · Placenta · doi:10.1016/j.placenta.2014.03.012 · Cited by 44
Candidate Placental Biomarkers for Intrauterine Alcohol Exposure
Shukla, P. K., Sittig, L. J., Ullmann, T. M., & Redei, E. E. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01373.x · Cited by 44
Telomerase activity in pregnancy complications (Review)
Fragkiadaki, P., Tsoukalas, D., Fragkiadoulaki, I., Psycharakis, C., Nikitovic, D., Spandidos, D. A., & Tsatsakis, A. M. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5231 · Cited by 41
Cell death mechanisms and their roles in pregnancy related disorders
Kasture, V., Sahay, A. S., & Joshi, S. (2021) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2021.01.006 · Cited by 40
Kajdy, A., Modzelewski, J., Cymbaluk‐Płoska, A., Kwiatkowska, E., Bednarek-Jędrzejek, M., Borowski, D., Stefanska, K. A., Rabijewski, M., Torbè, A., & Kwiatkowski, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084186 · Cited by 42
The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease
Hallows, S. E., Regnault, T. R. H., & Betts, D. H. (2012) · Journal of Pregnancy · doi:10.1155/2012/638476 · Cited by 42
Wilson, S. L., Liu, Y., & Robinson, W. P. (2016) · Placenta · doi:10.1016/j.placenta.2016.10.001 · Cited by 40
Biron‐Shental, T., Kidron, D., Halevy, R. S., Goldberg-Bittman, L., Sharony, R., Fejgin, M. D., & Amiel, A. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.08.024 · Cited by 39
A role for cellular senescence in birth timing
Cha, J. M., & Aronoff, D. M. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1371888 · Cited by 41
Imam, T., Jitratkosol, M. H. J., Soudeyns, H., Sattha, B., Gadawski, I., Maan, E. J., Forbes, J. C., Alimenti, A., Lapointe, N., Lamarre, V., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825aa89c · Cited by 36
Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos
Singh, V. P., McKinney, S., & Gerton, J. L. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.05.025 · Cited by 37
Hadchouel, A., Marchand‐Martin, L., Franco‐Montoya, M., Peaudecerf, L., Ancel, P., Delacourt, C., & EPIPAGEADO study group (2015) · PLoS ONE · doi:10.1371/journal.pone.0136123 · Cited by 35
Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
Ciampa, E. J., Flahardy, P., Srinivasan, H., Jacobs, C. L., Tsai, L. T.-Y., Karumanchi, S. A., & Parikh, S. M. (2023) · eLife · doi:10.7554/elife.85597 · Cited by 39
Telomere shortening in intra uterine growth restriction placentas
Biron‐Shental, T., Halevy, R. S., Sharon, Y. A. M. V., Laish, I., Fejgin, M. D., & Amiel, A. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2014.06.003 · Cited by 33
Luo, Z., Luo, W., Li, S., Zhao, S., Sho, T., Xu, X., Zhang, J., Xu, W., & Xu, J. (2018) · Reproductive Biology · doi:10.1016/j.repbio.2018.09.002 · Cited by 33
Joó, J. G., Sulyok, E., Bódis, J., & Kornya, L. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45100511 · Cited by 38
Iozzo, P., Holmes, M. C., Schmidt, M. V., Cirulli, F., Guzzardi, M. A., Berry, A., Balsevich, G., Andreassi, M. G., Wesselink, J., Liistro, T., et al. (2014) · Obesity Facts · doi:10.1159/000362656 · Cited by 32
Cheng, S., Davis, S., & Sharma, S. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12851 · Cited by 31
Telomere-Related Disorders in Fetal Membranes Associated With Birth and Adverse Pregnancy Outcomes
Polettini, J., & da Silva, M. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.561771 · Cited by 34
Telomere homeostasis in IUGR placentas – A review
Biron‐Shental, T., Sadeh-Mestechkin, D., & Amiel, A. (2016) · Placenta · doi:10.1016/j.placenta.2015.11.006 · Cited by 30
Brooker, I. A., Fisher, J. J., Sutherland, J. M., & Pringle, K. G. (2024) · Placenta · doi:10.1016/j.placenta.2024.11.005 · Cited by 30
Regulatory Network of ARF in Cancer Development.
Ko, A., Han, S. Y., & Song, J. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0100 · Cited by 27
Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis
García-Martín, I., Janssen, A. B., Jones, R. E., Grimstead, J. W., Penketh, R., Baird, D. M., & John, R. M. (2017) · Placenta · doi:10.1016/j.placenta.2017.09.007 · Cited by 25
Telomere erosion as a placental clock: From placental pathologies to adverse pregnancy outcomes
Kohlrausch, F. B., & Keefe, D. L. (2020) · Placenta · doi:10.1016/j.placenta.2020.06.022 · Cited by 27
Farladansky‐Gershnabel, S., Gal, H., Kidron, D., Krizhanovsky, V., Amiel, A., Halevy, R. S., & Biron‐Shental, T. (2018) · Reproductive Sciences · doi:10.1177/1933719118811644 · Cited by 25
Duan, L., Schimmelmann, M., Wu, Y., Reisch, B., Faas, M. M., Kimmig, R., Winterhager, E., Köninger, A., & Gellhaus, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.597549 · Cited by 24
Strohmaier, J., van Dongen, J., Willemsen, G. A. H. M., Nyholt, D. R., Zhu, G., Codd, V., Novakovic, B., Hansell, N. K., Wright, M. J., Rietschel, L., et al. (2015) · Twin Research and Human Genetics · doi:10.1017/thg.2015.3 · Cited by 20
Adverse Birth Outcomes and Birth Telomere Length: A Systematic Review and Meta-Analysis
Niu, Z., Li, K., Xie, C., & Wen, X. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.08.040 · Cited by 22
Cellular senescence in normal and adverse pregnancy
Farfán-Labonne, B., Leff-Gelman, P., Pellón-Díaz, G., & Camacho-Arroyo, I. (2023) · Reproductive Biology · doi:10.1016/j.repbio.2023.100734 · Cited by 19
Maternal Smoking in the First Trimester and its Consequence on the Early Placenta
Hoch, D., Majali‐Martinez, A., Bankoglu, E. E., Stopper, H., Glasner, A., Desoyé, G., Gauster, M., & Hiden, U. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2022.100059 · Cited by 23
Pearce, M. S., Mann, K. D., Martin-Ruiz, C. M., Parker, L., White, M. J., von Zglinicki, T., & Adams, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040116 · Cited by 21
Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
Kajdy, A., Sys, D., Modzelewski, J., Bogusławska, J., Cymbaluk‐Płoska, A., Kwiatkowska, E., Bednarek-Jędrzejek, M., Borowski, D., Stefanska, K. A., Rabijewski, M., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11071785 · Cited by 20
Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes
Lai, T., Simpson, M., Patel, K., Verhulst, S., Noh, J., Roche, N., Heller, D. S., Guirguis, G. F., Shay, J. W., Herbig, U., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84728-2 · Cited by 18
Christian, L. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.010 · Cited by 18
Laganović, M., Bendix, L., Rubelj, I., Kirhmajer, M. V., Slade, N., Lela, I. V., Premužić, V., Nilsson, P. M., & Jelaković, B. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000217 · Cited by 17
Louis‐Jacques, A. F., Salihu, H. M., King, L., Paothong, A., Sinkey, R. G., Pradhan, A., Riggs, B. M., Siegel, E. M., Salemi, J. L., & Whiteman, V. E. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.01.009 · Cited by 17
Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney
DeFreitas, M. J., Katsoufis, C. P., Benny, M., Young, K. C., Kulandavelu, S., Ahn, H., Sfakianaki, A. K., & Abitbol, C. L. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.853722 · Cited by 17
Impact of Dehydroepiandrosterone Sulfate on Newborn Leukocyte Telomere Length
Liu, H., Zhou, G., Chen, Q., Ouyang, F., Little, J., Zhang, J., & Chen, D. (2017) · Scientific Reports · doi:10.1038/srep42160 · Cited by 17
Pregnancy outcomes in mothers of offspring with inherited bone marrow failure syndromes
Giri, N., Reed, H. D., Stratton, P., Savage, S. A., & Alter, B. P. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26757 · Cited by 15
Symptoms of Prenatal Depression Associated with Shorter Telomeres in Female Placenta
García-Martín, I., Penketh, R., Garay, S. M., Jones, R. E., Grimstead, J. W., Baird, D. M., & John, R. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147458 · Cited by 14
Transcriptional profiles of genes related to mitochondrial aging in placental pathologies
Bartho, L. A., McKeating, D. R., Hannan, N. J., Kaitu’u‐Lino, T. J., & Perkins, A. V. (2022) · Molecular Human Reproduction · doi:10.1093/molehr/gaac026 · Cited by 14
Gestational exposure to NO2 aggravates placental senescence
Zhu, N., Geng, X., Ji, X., Gao, R., Li, D., Yue, H., Li, G., & Sang, N. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113263 · Cited by 13
Montero, C. G., Fraile‐Μartinez, O., León-Oliva, D. D., Boaru, D. L., García-Puente, L. M., León-Luis, J. A. D., Bravo, C., Dı́az, R., López-González, L., Álvarez‐Mon, M., et al. (2023) · Antioxidants · doi:10.3390/antiox12111918 · Cited by 15
Pregnancy Disorders: A Potential Role for Mitochondrial Altered Homeostasis
Toledano, J. M., Puche-Juárez, M., Gálvez-Navas, J. M., Moreno‐Fernández, J., Díaz‐Castro, J., & Ochoa, J. J. (2024) · Antioxidants · doi:10.3390/antiox13080979 · Cited by 16
Can telomere shortening be the main indicator of non-viable fetus elimination?
Huleyuk, N. L., Tkach, I. R., Zastavna, D. V., & Tyrka, M. (2018) · Molecular Cytogenetics · doi:10.1186/s13039-018-0361-9 · Cited by 13
Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood
Ravlić, S., Vidaček, N. Š., Nanić, L., Laganović, M., Slade, N., Jelaković, B., & Rubelj, I. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.014 · Cited by 12
Pathomechanisms of Prenatally Programmed Adult Diseases
Sulyok, E., Farkas, B., & Bódis, J. (2023) · Antioxidants · doi:10.3390/antiox12071354 · Cited by 13
Telomere Length and Telomerase Activity in Foetal Membranes from Term and Spontaneous Preterm Births
Colatto, B. N., Nascimento, I. R. V., Schinke, L. A. A., Noda-Nicolau, N. M., da Silva, M. G., Morceli, G., Menon, R., & Polettini, J. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00054-z · Cited by 11
Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length
Lis, N., Lamnisos, D., Tzanetakou, A. B. , Hadjimbei, E., & Tzanetakou, I. P. (2023) · Nutrients · doi:10.3390/nu15234975 · Cited by 13
Hay, E., Lucariello, A., Contieri, M., Trucillo, M., Pavese, L., Guerra, G., Falco, M. D., Luca, A. D., & Perna, A. (2020) · Placenta · doi:10.1016/j.placenta.2020.04.006 · Cited by 10
Başer, E., İnandıklıoğlu, N., Kırmızı, D. A., Ercan, F., Caniklioğlu, A., Kara, M., Onat, T., & Yalvaç, S. (2022) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-1938-0010 · Cited by 9
Kell, D. B., Kell, L., Kenny, L. C., Merriel, A., Moore, J. B., & Pretorius, E. (2025) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2025.104621 · Cited by 10
Characterization of senescence-associated transcripts in the human placenta
Barak, O., Bauer, A. D., Parks, W. T., Lovelace, T. C., Benos, P. V., Chu, T., & Sadovsky, Y. (2025) · Placenta · doi:10.1016/j.placenta.2025.01.009 · Cited by 8
Manna, S., McElwain, C. J., Maher, G. M., Martín, M. G., Musumeci, A., McCarthy, F. P., & McCarthy, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043101 · Cited by 8
Perales‐Puchalt, A., Soberón, N. E., Monterde, M., Hervás, D., Foronda, M., Real, D. D., Soler, I., Alfredo Perales, M., Pellicer, A., & Blasco, M. A. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.12.008 · Cited by 8
Reduced telomere length in amniocytes: an early biomarker of abnormal fetal development?
Goumy, C., Véronèse, L., Stamm, R., Domas, Q., Hadjab, K., Gallot, D., Laurichesse‐Delmas, H., Delabaere, A., Gouas, L., Salaün, G., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac054 · Cited by 8
Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates
Minamoto, T., Nakayama, K., Ishibashi, T., Ishikawa, M., Nakamura, K., Yamashita, H., Shanta, K., Mahmud, H. M., Razia, S., Iida, K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249688 · Cited by 9
Krapivin, M. I., Tikhonov, A. V., Efimova, O. A., Pendina, A. A., Smirnova, A. A., Chiryaeva, O. G., Евгеньевна, Т. О., Petrova, L., Dudkina, V. S., & Баранов, В. С. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126622 · Cited by 9
Lane‐Cordova, A. D., Puterman, E. M., Gunderson, E. P., Chan, C., Hou, L., & Carnethon, M. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186495 · Cited by 7
Understanding the Role of Telomere Dynamics in Normal and Dysfunctional Human Reproduction
Arias-Sosa, L. A. (2018) · Reproductive Sciences · doi:10.1177/1933719118804409 · Cited by 7
Placental telomere length and risk of placental abruption
Workalemahu, T., Enquobahrie, D. A., Yohannes, E., Sánchez, S. E., Gelaye, B., Qiu, C., & Williams, M. A. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1103224 · Cited by 7
Colicino, E., Cowell, W., Bozack, A. K., Pedretti, N. F., Joshi, A., Niedzwiecki, M. M., Bollati, V., Berin, M. C., Wright, R. O., & Wright, R. J. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110113 · Cited by 7
Increase in short telomeres during the third trimester in human placenta
Edelson, P. K., Sawyer, M. R., Gray, K. J., Cantonwine, D. E., McElrath, T. F., & Phillippe, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271415 · Cited by 6
Zinková, A., Marová, D., Koperdáková, J., Mirchi, T. P., Korabečná, M., & Jirkovská, M. (2017) · Placenta · doi:10.1016/j.placenta.2017.04.016 · Cited by 6
Metadata
- Authors
- Davy, P., Nagata, M., Bullard, P., Fogelson, N. S., & Allsopp, R.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Corresponding author
- Allsopp, R.
- ORCID
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 30
- Issue
- 6
- Pages
- 539-542
- ISSN
- 0143-4004 (ISSN-L)
- PMC
- PMC2692289
- OpenAlex
- W2048877882
- Cited by
- 137
- References
- 21
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 16 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 15 · 2016: 12 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 6
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p20rr011091-15)
- National Center for Research Resources (P20-RR011091)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- fetal growth restriction, telomere shortening, telomerase activity, cellular senescence, p21, p16, EF-1α, umbilical cord blood, placental development
- MeSH terms
- Adolescent, Adult, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Middle Aged, Pregnancy, Biomarkers, Up-Regulation, Case-Control Studies, Telomere, Cellular Senescence, Chromosomal Instability, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review