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Cited by 12Heart Rate Variability and Autonomic ControlPregnancy and preeclampsia studiesMaternal and fetal healthcare

Nonlinear analysis of fetal heart rate dynamics in fetuses compromised by asymptomatic partial placental abruption

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Choi, Won-Young, Hoh, Jeong-Kyu·2015·Placenta
DOI 10.1016/j.placenta.2015.10.002
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Abstract

Introduction We analyzed fetal heart rate (FHR) parameters, dynamics, and outcomes in pregnancies with asymptomatic partial placental abruption (PPA) compared with those in normal pregnancies.Methods We examined nonstress test (NST) data acquired from 2003 to 2012 at our institution. Normal pregnancies (N = 170) and PPA cases (N = 17) were matched for gestational age, fetal sex, and mean FHR. NSTs were performed at 33-42 weeks of gestation. FHR parameters obtained from the NST and perinatal outcomes were analyzed using linear methods. Nonlinear indices, including approximate entropy (ApEn), sample entropy (SampEn), short-term and long-term scaling exponents (α1 and α2), and correlation dimension (CD), were used to interpret FHR dynamics and system complexity. The area under a receiver operating characteristic curve (AUC) was used to evaluate the nonlinear indices.Results There were no significant differences in general characteristics and FHR parameters between the PPA and control groups. However, gestational age at delivery, birth weight, 5-min Apgar scores, ApEn, SampEn, and CD were significantly lower in the PPA group than in the control group (P < 0.05). The long-term scaling exponent (α2) and crossover index (α2/α1) of the PPA fetuses were significantly higher than those of the controls (P < 0.01). A multiple regression model showed better performance in predicting PPA (AUC, 0.92; sensitivity 82.35%; specificity, 94.12%).Discussion Nonlinear dynamic indices of FHR in asymptomatic PPA were qualitatively different from those in normal pregnancies, whereas the conventional FHR parameters were not significantly different.

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Authors
Choi, W.-Y., & Hoh, J.-K.
Affiliations
  • Hanbat National University (KR)
  • Hanyang University (KR)
Corresponding author
Hoh, Jeong-Kyu
ORCID
Hoh, Jeong-Kyu
Venue
Placenta
Publisher
Elsevier BV
Published
2015-12
Volume
36
Issue
12
Pages
1474-1479
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/j.placenta.2015.10.002
OpenAlex
W2180241589
Cited by
12
References
26
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
  • The Royal Society of Chemistry’s Journals, Books and Databases (The Royal Society of Chemistry) (submittedVersion, cc-by-nc-nd)
Funders
Research Fund of Hanyang University (201200000000601)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
Keywords
nonlinear dynamics, approximate entropy, sample entropy, correlation dimension, scaling exponents, nonstress test, perinatal outcomes, fetal well-being
MeSH terms
Abruptio Placentae, Adult, Female, Gestational Age, Heart Rate, Fetal, Humans, Male, Pregnancy, Nonlinear Dynamics, Young Adult

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