The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Selenium and spermine alleviate cadmium induced toxicity in the red seaweed Gracilaria dura by regulating antioxidants and DNA methylation
Abstract
The protective role of exogenously supplied selenium (Se) and polyamines (PAs) such as putrescine (Put) and spermine (Spm) in detoxifying the cadmium (Cd) induced toxicity was studied in the marine red alga Gracilaria dura in laboratory conditions. The Cd exposure (0.4 mM) impede the growth of alga while triggering the reactive oxygen species (ROS viz. O(2)(•-) and H(2)O(2)) generation, inhibition of antioxidant system, and enhancing the lipoxygenase (LOX) activity, malondialdehyde (MDA) level and demethylation of DNA. Additions of Se (50 μM) and/or Spm (1 mM) to the culture medium in contrast to Put, efficiently ameliorated the Cd toxicity by decreasing the accumulation of ROS and MDA contents, while restoring or enhancing the level of enzymatic and nonenzymatic antioxidants and their redox ratio, phycobiliproteins and phytochelatins, over the controls. The isoforms of antioxidant enzymes namely superoxide dismutase (Mn-SOD, ~150 kDa; Fe-SOD ~120 kDa), glutathione peroxidase (GSH-Px, ~120 and 140 kDa), glutathione reductase (GR, ~110 kDa) regulated differentially to Se and/or Spm supplementation. Furthermore, it has also resulted in enhanced levels of endogenous PAs (specially free and bound insoluble Put and Spm) and n-6 PUFAs (C20-3, n-6 and C20-4, n-6). This is for the first time wherein Se and Spm were found to regulate the stabilization of DNA methylation by reducing the events of cytosine demethylation in a mechanism to alleviate the Cd stress in marine alga. The present findings reveal that both Se and Spm play a crucial role in controlling the Cd induced oxidative stress in G. dura.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Photoperoxidation in isolated chloroplasts
Heath, R. L., & Packer, L. (1968) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(68)90654-1 · Cited by 11,413
HEAVY METAL–INDUCED OXIDATIVE STRESS IN ALGAE1
Pinto, E., Sigaud‐kutner, T. C. S., Leitão, M. A. S., Okamoto, O. K., Morse, D., & Colepicolo, P. (2003) · Journal of Phycology · doi:10.1111/j.0022-3646.2003.02-193.x · Cited by 1,066
A biological function for cadmium in marine diatoms
Lane, T. W., & Morel, F. M. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090091397 · Cited by 715
Selenium uptake, translocation, assimilation and metabolic fate in plants
Sors, T. G., Ellis, D. R., & Salt, D. E. (2005) · Photosynthesis Research · doi:10.1007/s11120-005-5222-9 · Cited by 700
Takiguchi, M., Achanzar, W. E., Qu, W., Li, G., & Waalkes, M. P. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00062-4 · Cited by 457
Biotic and heavy metal stress response in plants: evidence for common signals
Mithöfer, A., Schulze, B., & Boland, W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.04.011 · Cited by 423
Singh, S., Eapen, S., & D’Souza, S. F. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2005.05.017 · Cited by 383
Genome-wide transcriptome profiling of the early cadmium response of Arabidopsis roots and shoots
Herbette, S., Taconnat, L., Hugouvieux, V., Piette, L., Magniette, M.-L. M., Cuine, S., Auroy, P., Richaud, P., Forestier, C., Bourguignon, J., et al. (2006) · Biochimie · doi:10.1016/j.biochi.2006.04.018 · Cited by 357
The protective role of selenium in rape seedlings subjected to cadmium stress
Filek, M., Keskinen, R., Hartikainen, H., Szarejko, I., Janiak, A., Miszalski, Z., & Golda, A. (2008) · Journal of Plant Physiology · doi:10.1016/j.jplph.2007.06.006 · Cited by 272
Srivastava, S., Mishra, S., Tripathi, R. D., Dwivedi, S., & Gupta, D. K. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2006.10.006 · Cited by 231
Cited by
Cadmium toxicity in plants: Impacts and remediation strategies
Haider, F. U., Liqun, C., Coulter, J. A., Cheema, S. A., Wu, J., Zhang, R., Wenjun, M., & Farooq, M. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111887 · Cited by 1,541
Spermidine in health and disease
Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154
Gao, M., Zhou, J., Liu, H., Zhang, W., Hu, Y., Liang, J., & Zhou, J. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.03.047 · Cited by 328
Algal lipids, fatty acids and sterols
Kumari, P., Kumar, M., Reddy, C. R. K., & Jha, B. (2013) · Functional Ingredients from Algae for Foods and Nutraceuticals · doi:10.1533/9780857098689.1.87 · Cited by 163
Self-citation
Metadata
- Authors
- Kumar, M., Bijo, A. J., Baghel, R. S., Reddy, C. R. K., & Jha, B.
- Venue
- Plant Physiology and Biochemistry
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 51
- Pages
- 129-138
- ISSN
- 0981-9428 (ISSN-L)
- OpenAlex
- W2000254904
- Cited by
- 277
- References
- 30
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Selenium and spermine alleviate cadmium induced toxicity in the red seaweed Gracilaria dura by regulating antioxidants and DNA methylation. https://app.cochat.ai/papers/10.1016/j.plaphy.2011.10.016
- The paper
- Kumar, M., Bijo, A. J., Baghel, R. S., Reddy, C. R. K., & Jha, B. (2012). Selenium and spermine alleviate cadmium induced toxicity in the red seaweed Gracilaria dura by regulating antioxidants and DNA methylation. Plant Physiology and Biochemistry. https://doi.org/10.1016/j.plaphy.2011.10.016
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
