Cited by 68Allelopathy and phytotoxic interactionsPlant Stress Responses and TolerancePlant biochemistry and biosynthesis

Mechanism of artemisinin phytotoxicity action: Induction of reactive oxygen species and cell death in lettuce seedlings

Yan, Zhi-Qiang, Wang, Dan-Dan, Ding, Lan, Cui, Hai-Yan, Jin, Hui, Yang, Xiao-Yan, Yang, Jian-She, Qin, Bo·2015·Plant Physiology and Biochemistry

Abstract

Artemisinin has been recognized as an allelochemical that inhibits growth of several plant species. However, its mode of action is not well clarified. In this study, the mechanism of artemisinin phytotoxicity on lettuce seedlings was investigated. Root and shoot elongation of lettuce seedlings were inhibited by artemisinin in a concentration-dependent manner. The compound effectively arrested cell division and caused loss of cell viability in root tips of lettuce. Overproduction of reactive oxygen species (ROS) was induced by artemisinin. Lipid peroxidation, proline overproduction and reduction of chlorophyll content in lettuce seedlings were found after treatments. These results suggested that artemisinin could induce ROS overproduction, which caused membrane lipids peroxidation and cell death, and impacted mitosis and physiological processes, resulting in growth inhibition of receptor plants.

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Crossref · 10.1016/j.plaphy.2015.01.010

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Authors
Yan, Z.-Q., Wang, D.-D., Ding, L., Cui, H.-Y., Jin, H., Yang, X.-Y., Yang, J.-S., & Qin, B.
Affiliations
  • Northwest Normal University (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
Qin, Bo
Venue
Plant Physiology and Biochemistry
Publisher
Elsevier BV
Published
2015-03
Volume
88
Pages
53-59
ISSN
0981-9428 (ISSN-L)
OpenAlex
W1982042182
Cited by
68
References
44
Citations by year
2026: 3 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 1
FWCI
5.64
Type
journal article
Language
en
Open access
closed
Locations
  • Plant Physiology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31070386, 31300290)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Allelopathy and phytotoxic interactions
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords
artemisinin, phytotoxicity, allelochemicals, reactive oxygen species, oxidative stress, lipid peroxidation, cell death, mitotic arrest, proline accumulation, chlorophyll loss, root elongation inhibition, lettuce seedlings, plant growth inhibition
MeSH terms
Cell Membrane, Chlorophyll, Mitosis, Pheromones, Proline, Lipid Peroxidation, Cell Death, Reactive Oxygen Species, Plant Roots, Meristem, Plant Shoots, Lactuca, Artemisia, Seedlings, Artemisinins, Allelopathy

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