Mechanism of artemisinin phytotoxicity action: Induction of reactive oxygen species and cell death in lettuce seedlings
Abstract
Artemisinin has been recognized as an allelochemical that inhibits growth of several plant species. However, its mode of action is not well clarified. In this study, the mechanism of artemisinin phytotoxicity on lettuce seedlings was investigated. Root and shoot elongation of lettuce seedlings were inhibited by artemisinin in a concentration-dependent manner. The compound effectively arrested cell division and caused loss of cell viability in root tips of lettuce. Overproduction of reactive oxygen species (ROS) was induced by artemisinin. Lipid peroxidation, proline overproduction and reduction of chlorophyll content in lettuce seedlings were found after treatments. These results suggested that artemisinin could induce ROS overproduction, which caused membrane lipids peroxidation and cell death, and impacted mitosis and physiological processes, resulting in growth inhibition of receptor plants.
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Artemisinin is phytotoxic.
“Artemisinin is phytotoxic (4)”
From <i>Artemisia annua</i> mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism (2016) · cites this paper as [4]
Artemisinin is cytotoxic to various cell types.
“the observation that artemisinin is known to be cytotoxic to various cell types (4, 33, 34)”
From <i>Artemisia annua</i> mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism (2016) · cites this paper as [4]
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- Authors
- Yan, Z.-Q., Wang, D.-D., Ding, L., Cui, H.-Y., Jin, H., Yang, X.-Y., Yang, J.-S., & Qin, B.
- Affiliations
- Northwest Normal University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Qin, Bo
- Venue
- Plant Physiology and Biochemistry
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 88
- Pages
- 53-59
- ISSN
- 0981-9428 (ISSN-L)
- OpenAlex
- W1982042182
- Cited by
- 68
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 1
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Plant Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31070386, 31300290)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Allelopathy and phytotoxic interactions
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- artemisinin, phytotoxicity, allelochemicals, reactive oxygen species, oxidative stress, lipid peroxidation, cell death, mitotic arrest, proline accumulation, chlorophyll loss, root elongation inhibition, lettuce seedlings, plant growth inhibition
- MeSH terms
- Cell Membrane, Chlorophyll, Mitosis, Pheromones, Proline, Lipid Peroxidation, Cell Death, Reactive Oxygen Species, Plant Roots, Meristem, Plant Shoots, Lactuca, Artemisia, Seedlings, Artemisinins, Allelopathy
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