Metabolism of α-linolenic acid in humans

The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina

Lauritzen, L. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00017-5 · Cited by 1,063

Conversion of α -linolenic acid to longer-chain polyunsaturated fatty acids in human adults

Burdge, G. C., & Calder, P. C. (2005) · Reproduction Nutrition Development · doi:10.1051/rnd:2005047 · Cited by 939

Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women

Burdge, G. C., & Wootton, S. A. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002689 · Cited by 812

Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men

Burdge, G. C., Jones, A. E., & Wootton, S. A. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002662 · Cited by 598

Physiological compartmental analysis of α-linolenic acid metabolism in adult humans

Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A., & Salem, N. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31576-5 · Cited by 592

Differential oxidation of individual dietary fatty acids in humans

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Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat

Leyton, J., Drury, P. J., & Crawford, M. A. (1987) · British Journal of Nutrition · doi:10.1079/bjn19870046 · Cited by 539

Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males

Emken, E. A., Adlof, R. O., & Gulley, R. M. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00054-9 · Cited by 488

Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants.

Salem, N., Wegher, B., Mena, P., & Uauy, R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.49 · Cited by 482

??-Linolenic acid metabolism in men and women: nutritional and biological implications

Burdge, G. (2004) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200403000-00006 · Cited by 426

Long-chain conversion of [13C]linoleic acid and α-linolenic acid in response to marked changes in their dietary intake in men

Hussein, N., Ah-Sing, E., Wilkinson, P., Leach, C., Griffin, B. A., & Millward, D. J. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400225-jlr200 · Cited by 371

Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n−3 fatty acids

James, M. J., Ursin, V. M., & Cleland, L. G. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1140 · Cited by 354

The Very Low Birth Weight Premature Infant Is Capable of Synthesizing Arachidonic and Docosahexaenoic Acids from Linoleic and Linolenic Acids

Carnielli, V. P., Wattimena, D. J. L., Luijendijk, I. H. T., Boerlage, A., Degenhart, H. J., & Sauer, P. J. J. (1996) · Pediatric Research · doi:10.1203/00006450-199607000-00029 · Cited by 287

Blood Volume

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What is the role of α‐linolenic acid for mammals?

Sinclair, A. J., Attar‐Bashi, N. M., & Li, D. (2002) · Lipids · doi:10.1007/s11745-002-1008-x · Cited by 264

Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]α-linolenic acid to longer-chain fatty acids and partitioning towards β-oxidation in older men

Burdge, G. C., Finnegan, Y. E., Minihane, A. M., Williams, C. M., & Wootton, S. A. (2003) · British Journal of Nutrition · doi:10.1079/bjn2003901 · Cited by 234

Effects of beef- and fish-based diets on the kinetics of n−3 fatty acid metabolism in human subjects

Pawlosky, R. J., Hibbeln, J. R., Lin, Y., Goodson, S., Riggs, P., Sebring, N., Brown, G. L., & Salem Jr, N. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.3.565 · Cited by 180

Compartmental modeling to quantify α-linolenic acid conversion after longer term intake of multiple tracer boluses

Goyens, P. L. L., Spilker, M. E., Zock, P. L., Katan, M. B., & Mensink, R. P. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400514-jlr200 · Cited by 173

Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle

Evans, K., Burdge, G. C., Wootton, S. A., Clark, M. L., & Frayn, K. N. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2684 · Cited by 161

Intermediates in Endogenous Synthesis of C22:6ω3 and C20:4ω6 by Term and Preterm Infants

Sauerwald, T. U., Hachey, D. L., Jensen, C. L., Chen, H., Anderson, R. E., & Heird, W. C. (1997) · Pediatric Research · doi:10.1203/00006450-199702000-00005 · Cited by 149

Effects of dietary α‐linolenic acid on the conversion and oxidation of13C‐α‐linolenic acid

Vermunt, S. H. F., Mensink, R. P., Simonis, M. M. G., & Hornstra, G. (2000) · Lipids · doi:10.1007/bf02664762 · Cited by 148

In vivo conversion of linoleic acid to arachidonic acid in human adults

Salem, N., Pawlosky, R. J., Wegher, B., & Hibbeln, J. R. (1999) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(99)80021-0 · Cited by 136

Oxidative desaturation of α‐linolenic, linoleic, and stearic acids by human liver microsomes

Dumm, I. N. T. D. G., & Brenner, R. R. (1975) · Lipids · doi:10.1007/bf02532451 · Cited by 133

A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women

McCloy, U., Ryan, M. A., Pencharz, P. B., Ross, R. J., & Cunnane, S. C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300304-jlr200 · Cited by 130

The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids

Sprecher, H. W. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0402 · Cited by 126

n-3 Fatty acid metabolism in women

Pawlosky, R. J., Hibbeln, J. R., Lin, Y., & Salem, N. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003985 · Cited by 126

[13C]bicarbonate kinetics in humans: intra- vs. interindividual variations

Irving, C. S., Wong, W. W., Shulman, R. J., Smith, E. O., & Klein, P. (1983) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1983.245.2.r190 · Cited by 118

Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope‐labeled oleic, linoleic, and linolenic acids by male subjects

Emken, E. A., Adlof, R. O., Duval, S. M., & Nelson, G. J. (1999) · Lipids · doi:10.1007/s11745-999-0424-2 · Cited by 115

Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys

Greiner, R. C. S., Zhang, Q., Goodman, K. J., Giussani, D. A., Nathanielsz, P. W., & Brenna, J. T. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37470-8 · Cited by 100

Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?

Cunnane, S. C., Ryan, M. A., Nadeau, C. R., Bazinet, R. P., Musa‐Veloso, K., & McCloy, U. (2003) · Lipids · doi:10.1007/s11745-003-1087-8 · Cited by 94

Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy

Burdge, G. C., Hunt, A. N., & Postle, A. D. (1994) · Biochemical Journal · doi:10.1042/bj3030941 · Cited by 78

Pathway of α-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids

Clouet, P., Niot, I., & Bezard, J. A. (1989) · Biochemical Journal · doi:10.1042/bj2630867 · Cited by 77

Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women

Jones, A. E., Stolinski, M., Smith, R. D., Murphy, J. L., & Wootton, S. A. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599000124 · Cited by 73

The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy

Postle, A. D., Al, M. D. M., Burdge, G. C., & Hornstra, G. (1995) · Early Human Development · doi:10.1016/0378-3782(95)01663-n · Cited by 70

Dietary Trans Fatty Acids Alter the Compositions of Microsomes and Mitochondria and the Activities of Microsome Δ6-Fatty Acid Desaturase and Glucose-6-Phosphatase in Livers of Pregnant Rats

Larqué, E., García-Ruiz, P. A., Pérez‐Llamas, F., Zamora, S., & Gil, Á. (2003) · Journal of Nutrition · doi:10.1093/jn/133.8.2526 · Cited by 70

Research Communication: Plant and Marine Derived (n-3) Polyunsaturated Fatty Acids Do Not Affect Blood Coagulation and Fibrinolytic Factors in Moderately Hyperlipidemic Humans

Finnegan, Y. E., Minihane, A. M., Williams, C. M., Howarth, D., Kew, S., Miller, G. J., & Calder, P. C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2210 · Cited by 68

Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women

Giltay, E. J., Duschek, E., Katan, M., Zock, P. L., Neele, S. J. M., & Netelenbos, J. C. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1820399 · Cited by 68

Evidence that liver microsomes of human neonates desaturate essential fatty acids

Poisson, J., Dupuy, R.-P., Sarda, P., Descomps, B., Narce, M., Rieu, D., & de Paulet, A. C. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90149-4 · Cited by 64

Analysis of the putative role of 24‐carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n‐6) and docosahexaenoic (22:6n‐3) acids

Infante, J. P., & Huszagh, V. A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00720-0 · Cited by 61

Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women

Burdge, G. C., & Wootton, S. A. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(03)00111-x · Cited by 61

Stable isotope approaches, applications, and issues related to polyunsaturated fatty acid metabolism studies

Emken, E. A. (2001) · Lipids · doi:10.1007/s11745-001-0807-4 · Cited by 40

Effect of the Δ6‐desaturase inhibitor SC‐26196 on PUFA metabolism in human cellsinhibitor SC‐26196 on PUFA metabolism in human cells

Harmon, S. D., Kaduce, T. L., Manuel, T. D., & Spector, A. A. (2003) · Lipids · doi:10.1007/s11745-003-1086-9 · Cited by 40

Hepatic microsomal and peroxisomal docosahexaenoate biosynthesis during piglet development

Li, Z., Kaplan, M. L., & Hachey, D. L. (2000) · Lipids · doi:10.1007/s11745-000-0649-0 · Cited by 37

Relative Fatty Acid Composition of Lecithin during Postmenopausal Replacement Therapy – A Comparison between Ethinyl Estradiol and Estradiol Valerate

Ottosson, U. B., Lagrelius, A., Rosing, U., & von Schoultz, B. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000299096 · Cited by 37

Preferential reduction in adipose tissue α‐linolenic acid (18∶3ω3) during very low calorie dieting despite supplementation with 18∶3ω3

Tang, A. B., Nishimura, K. Y., & Phinney, S. D. (1993) · Lipids · doi:10.1007/bf02537119 · Cited by 31

Isomerization increases the postprandial oxidation of linoleic acid but not α-linolenic acid in men

Brétillon, L., Chardigny, J., Sébédio, J. L., Noël, J. P., Scrimgeour, C. M., Fernie, C. E., Loreau, O., Gachon, P., & Beaufrère, B. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31624-2 · Cited by 31

Absorption of triglyceride by human small intestine: dose-response relationships

Saunders, D., & Sillery, J. K. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.4.988 · Cited by 30

The effect of age and gender on the metabolic disposal of [1-13C]palmitic acid

Jones, A., Murphy, J., Stolinski, M., & Wootton, S. A. (1998) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600501 · Cited by 28

Adipose tissue fatty acids in men from two populations with different cardiovascular risk: the LiVicordia study

Kaminskas, A., Ziedén, B., Elwing, B., Kristenson, M., Abaravičius, A., Bergdahl, B., OLSSON, A. G., & Kučinskienė, Z. A. (1999) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519950185751 · Cited by 12

The fundamentals and practice of docosahexaenoic acid therapy in peroxisomal disorders

Martínez, M. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200003000-00004 · Cited by 4

Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids: Nutrition Reviews©, Vol. 68, No. 5

Wall, R., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00287.x · Cited by 1,101

Dietary n−6 and n−3 polyunsaturated fatty acids: From biochemistry to clinical implications in cardiovascular prevention

Russo, G. L. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.020 · Cited by 844

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements

Plourde, M., & Cunnane, S. C. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-034 · Cited by 583

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

Baker, E. J., Miles, E. A., Burdge, G. C., Yaqoob, P., & Calder, P. C. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.07.002 · Cited by 472

Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans

Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.016 · Cited by 412