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Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids
Open accessAbstract
Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and multifaceted, resulting in an incomplete understanding of their molecular mechanisms of action. Here, we focus on a highly conserved mechanism of n-3 PUFA, which is the alteration of the organization of the plasma membrane. We highlight recent work demonstrating that enrichment of n-3 PUFA in the plasma membrane alters the lateral organization of membrane signaling assemblies (i.e. lipid rafts). This mechanism is central for n-3 PUFA regulation of downstream signaling, T-cell activation, transcriptional activation, and cytokine secretion. We conclude that these studies provide strong evidence for a predominant mechanism by which n-3 PUFA function in colon cancer prevention.
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Distribution, interconversion, and dose response of n-3 fatty acids in humans.
Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162
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Zalba, S., & ten Hagen, T. L. M. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.10.008 · Cited by 365
Harris, W. S., Del Gobbo, L., & Tintle, N. L. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.05.007 · Cited by 183
Metadata
- Authors
- Turk, H. F., & Chapkin, R. S.
- Venue
- Prostaglandins, Leukotrienes and Essential Fatty Acids
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 88
- Issue
- 1
- Pages
- 43-47
- ISSN
- 0952-3278 (ISSN-L)
- OpenAlex
- W2034888385
- Cited by
- 192
- References
- 1
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Turk, H. F., & Chapkin, R. S. (2013). Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. https://doi.org/10.1016/j.plefa.2012.03.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
