The DOI matches its Crossref record; 289 of the 289 references it cites were found in a registry or an index.
Heat shock proteins: Cellular and molecular mechanisms in the central nervous system
Open accessAbstract
Emerging evidence describe heat shock proteins (HSPs) as critical regulators in normal neural physiological function as well as in cell stress responses. The functions of HSPs represent an enormous and diverse range of cellular activities, far beyond the originally identified role in protein folding and chaperoning. Now understood to be involved in processes such as synaptic transmission, autophagy, ER stress response, protein kinase and cell death signaling as well as protein chaperone and folding, manipulation of HSPs have robust effects on the fate of cells in neurological injury and disease states. The ongoing exploration of multiple HSP superfamilies has underscored the pluripotent nature of HSPs in the cellular context, and demanded the recent restructuring of the nomenclature referring to these families to reflect a re-organization based on structure and function. In keeping with this re-organization, we have first discussed the HSP superfamilies in terms of protein structure, regulation and expression and distribution in the brain. We then explore major cellular functions of HSPs that are relevant to neural physiological states, and from there discuss known and proposed HSP impact on major neurological disease states. This review article presents a three-part discussion on the array of HSPs families relevant to neuronal tissue, their cellular functions, and the exploration of therapeutic targets of these proteins in the context of neurological diseases.
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Metadata
- Authors
- Stetler, R. A., Gan, Y., Zhang, W., Liou, A. K., Gao, Y., Cao, G., & Chen, J.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 92
- Issue
- 2
- Pages
- 184-211
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2051479964
- Cited by
- 305
- References
- 289
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Stetler, R. A., Gan, Y., Zhang, W., Liou, A. K., Gao, Y., Cao, G., & Chen, J. (2010). Heat shock proteins: Cellular and molecular mechanisms in the central nervous system. Progress in Neurobiology. https://doi.org/10.1016/j.pneurobio.2010.05.002
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