The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
Open accessAbstract
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecular chaperones. Upon ER stress, ATF6 translocates from the ER to the Golgi where it is processed to its active form. We have found that the ER chaperone BiP/GRP78 binds ATF6 and dissociates in response to ER stress. Loss of BiP binding correlates with the translocation of ATF6 to the Golgi, which was slowed in cells overexpressing BiP. Two Golgi localization signals (GLSs) were identified in ATF6. Removal of BiP binding sites from ATF6, while retaining a GLS, resulted in its constitutive translocation to the Golgi. These results suggest that BiP retains ATF6 in the ER by inhibiting its GLSs and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi.
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Self-citationIRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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Self-citationRegulated Intramembrane Proteolysis
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The Unfolded Protein Response and Cell Fate Control
Hetz, C., & Papa, F. R. (2018) · Molecular Cell · doi:10.1016/j.molcel.2017.06.017 · Cited by 1,544
Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond
Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272
The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus
Eizirik, D. L., Cardozo, A. K., & Cnop, M. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0015 · Cited by 1,173
Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086
Metadata
- Authors
- Shen, J., Chen, X., Hendershot, L., & Prywes, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 3
- Issue
- 1
- Pages
- 99-111
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1988482079
- Cited by
- 1,456
- References
- 47
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shen, J., Chen, X., Hendershot, L., & Prywes, R. (2002). ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals. Developmental Cell. https://doi.org/10.1016/s1534-5807(02)00203-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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