The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Neurobiological studies of fatigue
Open accessAbstract
Fatigue is a symptom associated with many disorders, is especially common in women and in older adults, and can have a huge negative influence on quality of life. Although most past research on fatigue uses human subjects instead of animal models, the use of appropriate animal models has recently begun to advance our understanding of the neurobiology of fatigue. In this review, results from animal models using immunological, developmental, or physical approaches to study fatigue are described and compared. Common across these animal models is that fatigue arises when a stimulus induces activation of microglia and/or increased cytokines and chemokines in the brain. Neurobiological studies implicate structures in the ascending arousal system, sleep executive control areas, and areas important in reward. In addition, the suprachiasmatic nucleus clearly plays an important role in homeostatic regulation of the neural network mediating fatigue. This nucleus responds to cytokines, shows decreased amplitude firing rate output in models of fatigue, and responds to exercise, one of our few treatments for fatigue. This is a young field but very important as the symptom of fatigue is common across many disorders and we do not have effective treatments.
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Citations
Cites
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Cited by
Sorted by citations
Tran, Y., Craig, A. R., Craig, R., Chai, R., & Nguyen, H. T. (2020) · Psychophysiology · doi:10.1111/psyp.13554 · Cited by 323
Fatigue, Sleep, and Autoimmune and Related Disorders
Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 281
“Several brain areas are associated with modulating fatigue (Table 2) (243), although this area of research remains poorly investigated.”
BackgroundThe dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders
Dobryakova, E., Genova, H. M., DeLuca, J., & Wylie, G. R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00052 · Cited by 242
“A large body of evidence in support of the cytokine hypothesis comes from animal literature (8, 89).”
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Langeskov‐Christensen, M., Bisson, E. J., Finlayson, M. L., & Dalgas, U. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.01.002 · Cited by 105
Metadata
- Authors
- Harrington, M. E.
- Affiliations
- Smith College (US)
- Corresponding author
- Harrington, Mary E.
- ORCID
- Harrington, Mary E.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 99
- Issue
- 2
- Pages
- 93-105
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC3479364
- OpenAlex
- W2038548714
- Cited by
- 112
- References
- 168
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Smith ScholarWorks (Smith College) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R21CA125215)
- National Institute of Nursing Research (R21NR012845)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- fatigue, microglial activation, cytokines, chemokines, ascending arousal system, reward, suprachiasmatic nucleus, homeostatic regulation, physical activity, quality of life
- MeSH terms
- Animals, Brain, Disease Models, Animal, Fatigue, Humans, Neurobiology, Fatigue Syndrome, Chronic, Autoimmune Diseases of the Nervous System
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