Cited by 57Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Pharmacological studies with endogenous enhancer substances: β-phenylethylamine, tryptamine, and their synthetic derivatives

Shimazu, Seiichiro, Miklya, Ildikó·2004·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

The discovery of enhancer regulation in the mesencephalon and the concept that it plays a key role in the operation of innate and acquired drives [Neurochem. Res. 28 (2003) 1187] sets the trace amines (TAs) in their true physiological perspective. The regulation is defined as the existence of enhancer-sensitive neurons in the brain capable of working in a split-second on a high activity level due to endogenous enhancer substances. For the time being, only beta-phenylethylamine (PEA) and tryptamine are the experimentally analyzed examples. (-)-Deprenyl (selegiline), widely used in Parkinson's disease and Alzheimer's disease today, and known as the first selective monoamine oxidase (MAO) type-B inhibitor for decades, was identified as a PEA-derived synthetic mesencephalic enhancer substance. An important and convincing confirmation of the enhancer concept was the recent development of a highly specific and potent tryptamine-derived synthetic mesencephalic enhancer substance, (-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP]. This substance, which is specific and hundreds of times more potent than selegiline, is now the best experimental tool to study the enhancer regulation in the mesencephalon and a promising candidate to significantly surpass the therapeutic efficiency of selegiline in depression, Parkinson's disease, and Alzheimer's disease.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2003.11.016

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Beta-phenylethylamine derived from phenylalanine or tryptamine originated from tryptophan can exert beneficial actions such as mood control and appetite/satiety balance regulation when administered to humans.

    “beta-phenylethylamine derived from phenylalanine or tryptamine originated from tryptophan can exert beneficial actions (such as mood control and appetite/satiety balance regulation) when administered to humans (Shimazu and Miklya, 2004).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Shimazu, S., & Miklya, I.
Affiliations
  • Fujimoto Pharmaceutical Corporation (Japan) (JP)
  • Semmelweis University (HU)
Corresponding author
Shimazu, Seiichiro
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2004-05
Volume
28
Issue
3
Pages
421-427
ISSN
0278-5846 (ISSN-L)
OpenAlex
W2070245731
Cited by
57
References
60
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
0.20
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
trace amines, enhancer regulation, phenylethylamine, tryptamine, selegiline, bilevel positive airway pressure, midbrain, monoamine oxidase B inhibition, depression, Parkinson's disease, Alzheimer's disease
MeSH terms
Animals, Antidepressive Agents, Benzofurans, Humans, Mesencephalon, Nervous System Diseases, Phenethylamines, Psychotropic Drugs, Selegiline, Tryptamines, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review