No pituitary gland volume change in medication-free depressed patients
Abstract
Increased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N=34) and age and sex matched healthy controls (N=39). PGV did not differ between MDD patients and healthy controls [mean volume+/-S.D.; 0.76+/-0.17 cm3 and 0.75+/-0.14 cm3; ANCOVA, F1,69=1.25 p>0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults.
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Pituitary volume changes have been reported in MDD with both increased, reduced or no change in volume.
“Pituitary volume changes have been reported in MDD with both increased (46, 47), reduced or not change in volume reported (48–50).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [48]
Cites
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Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis
Murphy, F., Nasa, A., Cullinane, D., Raajakesary, K., Gazzaz, A., Sooknarine, V., Haines, M., Roman, E., Kelly, L., O'Neill, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.748372 · Cited by 181 · see citing works
- Authors
- Eker, C., Ovali, G. Y., Ozan, E., Eker, O. D., Kitis, O., Coburn, K., & Gonul, A. S.
- Affiliations
- Atatürk University (TR)
- Mercer University (US)
- ORCID
- Ozan, Erol
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 32
- Issue
- 7
- Pages
- 1628-1632
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W1997610596
- Cited by
- 18
- References
- 5
- Citations by year
- 2023: 2 · 2022: 1 · 2019: 1 · 2017: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- pituitary gland volume, major depressive disorder, untreated depression, hypothalamic-pituitary-adrenal axis, cortisol, depression pathophysiology, brain MRI volumetry
- MeSH terms
- Adult, Analysis of Variance, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pituitary Gland, Chi-Square Distribution, Case-Control Studies
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