The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Therapeutic potential of cannabis-related drugs
Abstract
In this review, I will consider the dual nature of Cannabis and cannabinoids. The duality arises from the potential and actuality of cannabinoids in the laboratory and clinic and the 'abuse' of Cannabis outside the clinic. The therapeutic areas currently best associated with exploitation of Cannabis-related medicines include pain, epilepsy, feeding disorders, multiple sclerosis and glaucoma. As with every other medicinal drug of course, the 'trick' will be to maximise the benefit and minimise the cost. After millennia of proximity and exploitation of the Cannabis plant, we are still playing catch up with an understanding of its potential influence for medicinal benefit.
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“Chronic pain is one of the most frequent reasons why patients are accessing medicinal cannabis [15,16,24].”
From Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications (2023) · cites this paper as [16]
In the citing paper
“The majority of the studies implicate the CB1 receptor in the analgesic effects of cannabinoids, but there is also good evidence that CB2 receptor also contributes to these effects [16].”
From Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications (2023) · cites this paper as [16]
In the citing paper
“Several studies have already demonstrated that ECS is expressed in the areas responsible for pain control; indeed, endocannabinoids are considered pain modulators, exhibiting an analgesic effect in both inflammatory and neuropathic pain models [1,16].”
From Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications (2023) · cites this paper as [16]
In the citing paper
“However, other studies consider that there is substantial evidence to support that cannabis is effective in treating epilepsy [1,8,16,20].”
From Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications (2023) · cites this paper as [16]
Citations
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“Alexander [39] underscores the therapeutic potential of cannabis-related drugs, which can be further explored and optimized through AI-driven drug discovery and development.”
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“These properties include anti-epileptic and anti-convulsant effects (Alexander, 2016), neuroprotective actions (Tikoo et al., 2012), antiemetic capabilities (Whiting et al., 2015), analgesic effects (Bonini et al., 2018), as well as antibacterial and anti-in fl ammatory activities (Saxena, 2009).”
Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review
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“It also includes metabolic enzymes such as fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MAGL), which are responsible for the synthesis and degradation of endocannabinoids (Alexander, 2016; Aizpurua-Olaizola et al., 2017) (Figure 4).”
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“Anecdotal evidence and recent case reports talked about the therapeutic effect of cannabis sativa [1].”
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BindingDB Entry 7478: FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.
BindingDB (2016) · UC San Diego · doi:10.7270/q2ms3rjj
Metadata
- Authors
- Alexander, S. P. H.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Alexander, Stephen P.H.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 64
- Pages
- 157-166
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W1580068968
- Cited by
- 149
- References
- 135
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 24 · 2022: 13 · 2021: 15 · 2020: 10 · 2019: 28 · 2018: 14 · 2017: 14 · 2016: 6
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Keywords
- cannabis, cannabinoids, medical cannabis, pain, epilepsy, feeding disorders, multiple sclerosis, glaucoma, drug abuse, therapeutic potential
- MeSH terms
- Animals, Cannabinoids, Cannabis, Marijuana Abuse, Humans, Phytotherapy, Endocannabinoids
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