The DOI matches its Crossref record; 228 of the 229 references it cites were found in a registry or an index.
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Open accessAbstract
The high comorbidity of psychological disorders in both functional and organic gastrointestinal diseases suggests the intimate and complex link between the brain and the gut. Termed the brain-gut axis, this bidirectional communication between the central nervous system and enteric nervous system relies on immune, endocrine, neural, and metabolic pathways. There is increasing evidence that the gut microbiome is a key part of this system, and dysregulation of the brain-gut-microbiome axis (BGMA) has been implicated in disorders of brain-gut interaction, including irritable bowel syndrome, and in neuropsychiatric disorders, including depression, Alzheimer's disease, and autism spectrum disorder. Further, alterations in the gut microbiome have been implicated in the pathogenesis of organic gastrointestinal diseases, including inflammatory bowel disease. The BGMA is an attractive therapeutic target, as using prebiotics, probiotics, or postbiotics to modify the gut microbiome or mimic gut microbial signals could provide novel treatment options to address these debilitating diseases. However, despite significant advancements in our understanding of the BGMA, clinical data is lacking. In this article, we will review current understanding of the comorbidity of gastrointestinal diseases and psychological disorders. We will also review the current evidence supporting the key role of the BGMA in this pathology. Finally, we will discuss the clinical implications of the BGMA in the evaluation and management of psychological and gastrointestinal disorders.
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“Furthermore, gastrointestinal disorders such as IBD and IBS are frequently accompanied by persistent psychiatric comorbidities[6], [7], reinforcing the need for an integrated perspective in investigating these interconnected systems. [8].”
From The hidden genetic and microbial networks connecting neuropsychiatric and digestive disorders (2025) · cites this paper as [7]
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Items 201–228 of 228
Cebolla, A., Galiana, L., Campos, D., Oliver, A., Soler, J., Demarzo, M., Baños, R., Feliu‐Soler, A., & García‐Campayo, J. (2017) · Mindfulness · doi:10.1007/s12671-017-0826-7 · Cited by 47
The effect of psychotherapy on quality of life in IBD Patients: A systematic review
Paulides, E., Boukema, I., van der Woude, C. J., & de Boer, N. K. H. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa144 · Cited by 47
Cossu, G., Carta, M. G., Contu, F., Mela, Q., Demelia, L., Elli, L., & Dell’Osso, B. M. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1314952 · Cited by 46
Everitt, H., Landau, S., Little, P., Bishop, F. L., McCrone, P., O'Reilly, G., Coleman, N., Logan, R., Chalder, T., & Moss-Morris, R. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008622 · Cited by 45 · cited 1×
“There are also numerous studies supporting the use of different modes of delivery of CBT, including telephone sessions and internet platforms (Bonnert et al., 2017; H. Everitt et al., 2015).”
Longarzo, M., Quarantelli, M., Aiello, M., Romano, M., PRETE, A. D., Cimminiello, C., Cocozza, S., Olivo, G., Loguercio, C., Trojano, L., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9595-5 · Cited by 43
Increasing Frequency of Opioid Prescriptions for Chronic Abdominal Pain in US Outpatient Clinics
Dorn, S. D., Meek, P. D., & Shah, N. D. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.008 · Cited by 42
Brain-based Correlations Between Psychological Factors and Functional Dyspepsia
Nan, J., Liu, J., Mu, J., Dun, W., Zhang, M., Gong, Q., Qin, W., Tian, J., Liang, F., & Zeng, F. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14096 · Cited by 40
Efficacy and safety of probiotics in irritable bowel syndrome: A systematic review and meta-analysis
Jia, L.-Q., Sun, J.-R., Kong, C.-F., Qu, X.-K., Deng, C., & Lou, Y.-N. (2020) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_384_19 · Cited by 40
Antibiotics and probiotics in inflammatory bowel disease: when to use them?
Abraham, B. P., & Quigley, E. M. M. (2019) · Frontline Gastroenterology · doi:10.1136/flgastro-2018-101057 · Cited by 39
Overview of functional gastrointestinal disorders: dysfunction of the brain–gut axis
Mertz, H. R. (2003) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(03)00019-0 · Cited by 38
Association between gastrointestinal symptoms and affectivity in patients with bipolar disorder
Karling, P., Maripuu, M., Wikgren, M., Adolfsson, R., & Norrback, K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i38.8540 · Cited by 37
A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis
Kashyap, P., Johnson, S. P., Geno, D. M., Lekatz, H. R., Lavey, C. J., Alexander, J. A., Chen, J., & Katzka, D. A. (2019) · Physiological Reports · doi:10.14814/phy2.14261 · Cited by 37
Weinland, S. R., Morris, C. B., Dalton, C. B., Hu, Y., Whitehead, W. E., Toner, B. B., Diamant, N. E., Leserman, J., Bangdiwala, S. I., & Drossman, D. A. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.748 · Cited by 32
Chumpitazi, B. P. (2019) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000608 · Cited by 32
Hypnotherapy for Inflammatory Bowel Disease Across the Lifespan
Szigethy, E. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1040112 · Cited by 31
Food, mood, and brain health: implications for the modern clinician.
LaChance, L., & Ramsey, D. (2015) · Europe PMC (PubMed Central) · Cited by 27
Clinical Hypnosis in Pediatric Crohn's Disease
Lee, A. J., Moulton, D. E., McKernan, L. C., Russell, A. C., Slaughter, J. C., Acra, S. A., & Walker, L. S. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002980 · Cited by 27
Catastrophizing the Consequences of Gastrointestinal Symptoms in Irritable Bowel Syndrome
Hunt, M. G., Milonova, M., & Moshier, S. J. (2009) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.23.2.160 · Cited by 26
Cunningham, N. R., Jagpal, A., Peugh, J., Farrell, M. K., Cohen, M. B., Mezoff, A. G., Lynch-Jordan, A. M., & Kashikar‐Zuck, S. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001342 · Cited by 24
Sayuk, G. S., Kanuri, N. D., Gyawali, C. P., Gott, B. M., Nix, B. D., & Rosenheck, R. A. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14503 · Cited by 24
Malagelada, J. R. (2020) · Digestive Diseases · doi:10.1159/000505810 · Cited by 24
Probiotics for paediatric functional abdominal pain disorders: A rapid review
Ding, F. C. L., Karkhaneh, M., Zorzela, L., Jou, H., & Vohra, S. (2019) · Paediatrics & Child Health · doi:10.1093/pch/pxz036 · Cited by 19
Patel, R. S., Goyal, H., Satodiya, R. M., & Tankersley, W. E. (2019) · Substance Use & Misuse · doi:10.1080/10826084.2019.1664591 · Cited by 19
Celiac Disease, Gut-Brain Axis, and Behavior: Cause, Consequence, or Merely Epiphenomenon?
Fasano, A. (2017) · PEDIATRICS · doi:10.1542/peds.2016-4323 · Cited by 18
Adejumo, A., Ajayi, T. O., Adegbala, O. M., & Bukong, T. N. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001382 · Cited by 10
Fecal microbial transplant for inflammatory bowel disease
Claytor, J. D., & El‐Nachef, N. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000676 · Cited by 5
Kanuri, N. D., Abraham, P., Cassell, B. E., Bruce, S. E., White, K. S., Gott, B. M., Nix, B. D., Gyawali, C. P., & Sayuk, G. S. (2015) · Gastroenterology · doi:10.1016/s0016-5085(15)32222-8 · Cited by 4
Oudenhove, L. V., Labus, J. S., Dupont, P. J., Vandenberghe, J. U., Vos, R., Bormans, G. M., Laere, K. V., Demyttenaere, K., Mayer, E. A., & Tack, J. F. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)61710-6 · Cited by 1
Flagged first, then by citations
1 of the 229 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Garland, 2012, Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations, J Behav Med, 35, 591, 10.1007/s10865-011-9391-z · DOI · Paper page
Cited by
Sorted by citations
Gong, W., Guo, P., Li, Y., Liu, L., Yan, R., Liu, S., Wang, S., Xue, F., Zhou, X., & Yuan, Z. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.4974 · Cited by 225
Leigh, S., Uhlig, F., Wilmes, L., Sánchez-Díaz, P., Gheorghe, C. E., Goodson, M. S., Kelley‐Loughnane, N., Hyland, N. P., Cryan, J. F., & Clarke, G. A. (2023) · The Journal of Physiology · doi:10.1113/jp281951 · Cited by 201
Microbiota–neuroepithelial signalling across the gut–brain axis
Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147
Research progress in the treatment of slow transit constipation by traditional Chinese medicine
Wang, L., Wu, F., Hong, Y., Shen, L., Zhao, L., & Lin, X. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115075 · Cited by 76
Hung, L. Y., Alves, N. D., Colle, A. D., Talati, A., Najjar, S. A., Bouchard, V., Gillet, V., Tong, Y., Huang, Z., Browning, K. N., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.11.012 · Cited by 52
Metadata
- Authors
- Person, H., & Keefer, L.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Person, Hannibal
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 107
- Pages
- 110209
- ISSN
- 0278-5846 (ISSN-L)
- PMC
- PMC8382262
- OpenAlex
- W3111424608
- Cited by
- 158
- References
- 229
- Citations by year
- 2026: 31 · 2025: 52 · 2024: 28 · 2023: 23 · 2022: 19 · 2021: 5
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (TL1TR001434)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut-brain axis, psychological comorbidity, gastrointestinal diseases, irritable bowel syndrome, depression, Alzheimer's disease, autism spectrum disorder, inflammatory bowel disease, enteric nervous system, prebiotics, probiotics, postbiotics, gut dysbiosis
- MeSH terms
- Gastrointestinal Microbiome, Brain-Gut Axis, Mental Disorders, Brain, Gastrointestinal Diseases, Humans, Comorbidity, Enteric Nervous System, Probiotics, Irritable Bowel Syndrome, Prebiotics
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