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Preparation and controlled degradation of oxidized sodium alginate hydrogel
Open accessAbstract
Abstract Degradation is often a critical property of materials utilized in tissue engineering. Although alginate, a naturally derived polysaccharide, is an attractive material due to its biocompatibility and ability to form hydrogels, its slow and uncontrollable degradation can be an undesirable feature. In this study, the degradation behavior of hydrogel based on oxidized sodium alginate (OSA) crosslinked with Ca 2+ was studied in phosphate buffer solution (PBS, pH = 7.4) and Tris-(hydroxymethyl) aminomethane–HCl (Tris–HCl, pH = 7.4) at 37 °C. The degradation behavior of OSA hydrogels with different degrees of oxidation was evaluated as a function of degradation time by monitoring the changes of molecular weight and weight loss. It was found that the degradation behavior relied heavily on the degree of oxidation and the surrounding medium. This result indicates that the degradation rates of OSA hydrogels can be controlled by changing the degree of oxidation.
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Hernández-González, A. C., Téllez-Jurado, L., & Rodríguez-Lorenzo, L. M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115514 · Cited by 549
Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels
Gul, K., Gan, R.-Y., Sun, C.-X., Jiao, G., Wu, D.-T., Li, H.-B., Kenaan, A., Corke, H., & Fang, Y.-P. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1870034 · Cited by 144
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Zhu, S., Dou, W., Zeng, X., Chen, X., Gao, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105249 · Cited by 28
Metadata
- Authors
- Gao, C., Liu, M., Chen, J., & Zhang, X.
- Venue
- Polymer Degradation and Stability
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 94
- Issue
- 9
- Pages
- 1405-1410
- ISSN
- 0141-3910 (ISSN-L)
- OpenAlex
- W2061581943
- Cited by
- 177
- References
- 0
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Gao, C., Liu, M., Chen, J., & Zhang, X. (2009). Preparation and controlled degradation of oxidized sodium alginate hydrogel. Polymer Degradation and Stability. https://doi.org/10.1016/j.polymdegradstab.2009.05.011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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