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Cited by 28Surgical Sutures and Adhesivesbiodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applications

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

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Zhu, Shuzhuang, Dou, Wenguang, Zeng, Xiaojun, Chen, Xingchao, Gao, Yonglin, Liu, Hongliang, Li, Sidi·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25105249PMC PMC11121545
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Abstract

In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal tissue damage. Since most tissue adhesives are designed for internal use or wound treatments, the biodegradation of adhesives is important. To endow tissue adhesives with biodegradability, in the past few decades, various biodegradable polymers, either natural polymers (such as chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional proteins, and peptides) or synthetic polymers (such as poly(lactic acid), polyurethanes, polycaprolactone, and poly(lactic-co-glycolic acid)), have been utilized to develop novel biodegradable tissue adhesives. Incorporated biodegradable polymers are degraded in vivo with time under specific conditions, leading to the destruction of the structure and the further degradation of tissue adhesives. In this review, we first summarize the strategies of utilizing biodegradable polymers to develop tissue adhesives. Furthermore, we provide a symmetric overview of the biodegradable polymers used for tissue adhesives, with a specific focus on the degradability and applications of these tissue adhesives. Additionally, the challenges and perspectives of biodegradable polymer-based tissue adhesives are discussed. We expect that this review can provide new inspirations for the design of novel biodegradable tissue adhesives for biomedical applications.

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  • Diabetic wounds often involve exacerbated inflammation and an overabundance of reactive oxygen species (ROS).

    “Diabetic wounds often involve exacerbated inflammation and an overabundance of reactive oxygen species (ROS) [109,110].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [109]

    Section 3.1 (Natural Polymers; page not provided) says high blood sugar causes excessive ROS accumulation in diabetic wounds, supporting the ROS portion. It discusses infection and difficulty healing but does not state that diabetic wounds involve exacerbated inflammation. (LLM, conf=0.88)

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200 of 214 shown

Cited by

Sorted by citations

Authors
Zhu, S., Dou, W., Zeng, X., Chen, X., Gao, Y., Liu, H., & Li, S.
Affiliations
Yantai University (CN)
Corresponding author
  • Liu, Hongliang
  • Li, Sidi
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-05-11
Volume
25
Issue
10
Pages
5249
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms25105249
PMC
PMC11121545
OpenAlex
W4396891791
Cited by
28
References
3
Citations by year
2026: 7 · 2025: 16 · 2024: 5
FWCI
3.09
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541)
  • Natural Science Foundation of Shandong Province (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541)
  • Taishan Young Scholar Program (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541)
  • Fundamental Research Projects of Science and Technology Innovation and Development Plan in Yantai City (52203280, 22375172, ZR2022QE040, tsqn202103053, 2022YTJC06002541)
Topics
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
tissue adhesives, biodegradable polymers, biodegradation, wound closure, natural polymers, synthetic polymers, chitosan, hyaluronic acid, gelatin, polylactic acid, poly(lactic-co-glycolic acid), polycaprolactone, polyurethane, sodium alginate, starch, pectin, glucan, biodegradable biomaterials
MeSH terms
Animals, Biocompatible Materials, Humans, Polymers, Tissue Adhesives, Chitosan, Biodegradable Plastics

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