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Severity of depressive and motor symptoms impacts quality of life in Parkinson’s disease patients at an academic movement clinic: A cross-sectional study
Open accessAbstract
Introduction: Parkinson's disease (PD) is a neurodegenerative disease with motor and non-motor manifestations that have been previously reported to affect patient quality of life (QoL). Our objective is to investigate the factors that contribute to QoL in a cohort of PD patients receiving care at a major academic institution. Methods: In this cross-sectional study of 124 participants (71.77% male, mean age 65.20, mean UPDRS-III score 11.25), we analyzed if certain clinical features such as UPDRS-III, QIDS-C, and total disease duration contributed to QoL as measured by two different metrics (PDQ-39 and EQ-5D) in PD patients at a university Movement Disorders Clinic. Results: Total score) contributing most to QoL scores. Of the specific depressive and motor symptoms, anhedonia and rigidity contributed the most to QoL. Disease duration was significantly correlated with lower QoL for participants with Parkinson's according to the QoL metric PDQ-39 but not ED-5D. Parkinson's patients with access to high-quality healthcare are at risk for having diminished QoL due to both depressive and motor symptoms. Conclusion: While severity of motor symptoms certainly impacted QoL in our cohort, our findings suggest that depressive symptoms contribute more to impaired QoL than severe motor symptoms do. This phenomenon suggests that concomitant depression in PD as well as one's psychological adjustment to disability may have a greater impact on QoL than severe motor symptoms.
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The majority of people with Parkinson's disease experience significant distress affecting their psychological wellbeing and quality of life.
“the majority of people with PD experience significant distress affecting their psychological wellbeing and quality of life (Lacy et al., 2023)”
From A Systematic Review of Third-Wave Therapies to Reduce Distress and Improve Wellbeing and Quality of Life in People with Parkinson's Disease. (2025) · cites this paper as Lacy et al., 2023
The Introduction (page not provided) says Parkinson’s disease can significantly affect quality of life and identifies depression as a common symptom. The Discussion (page not provided) links depressive symptoms with poorer quality of life. Neither section establishes that a majority of people with Parkinson’s disease experience significant psychological distress. (LLM, conf=0.86)
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Metadata
- Authors
- Lacy, B., Piotrowski, H. J., Dewey, R. B., & Husain, M. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Piotrowski, Hien J.
- Venue
- Clinical Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2023
- Volume
- 8
- Pages
- 100180
- ISSN
- 2590-1125 (ISSN-L)
- PMC
- PMC9795528
- OpenAlex
- W4312083157
- Cited by
- 27
- References
- 29
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 7 · 2023: 4
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Parkinsonism & Related Disorders (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (1RC1NS068983, K23MH087739)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, quality of life, depressive symptoms, motor symptoms, anhedonia, rigidity, disease duration, UPDRS-III, PDQ-39, EQ-5D
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