The Frontotemporal Dementias
Abstract
Frontotemporal dementia (FTD) is a heterogeneous group of hereditary and sporadic neurodegenerative disorders affecting frontotemporal areas. FTD, a leading cause of young-onset dementia, is often initially mistaken for primary psychiatric disorders. Based on early and predominant symptoms, different clinical syndromes can be distinguished: the behavioral variant and 2 variants of progressive aphasia; semantic dementia and progressive nonfluent aphasia. Neuropathological classification is based on protein accumulation in the brain. Pathogenic mutations in different genes have been identified. Specific pharmacological treatment is the main research goal. Meanwhile the management must focus on early correct diagnosis, symptom alleviation, caregiver support and educational interventions.
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bvFTD presentation is characterized by changes in personality and behavior, most notably apathy, disinhibition, loss of self-awareness, and loss of empathy.
“Typically, the presentation is characterized by changes in personality and behavior, most notably apathy, disinhibition, loss of self-awareness, and loss of empathy [11, 18].”
From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [18]
Cites
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Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road
Sawyer, R. P., Rodriguez-Porcel, F., Hagen, M., Shatz, R., & Espay, A. J. (2017) · Journal of Clinical Movement Disorders · doi:10.1186/s40734-017-0052-4 · Cited by 40 · see citing works
- Authors
- Waldö, M. L.
- Affiliations
- Lund University (SE)
- Corresponding author
- Waldö, Maria Landqvist
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 38
- Issue
- 2
- Pages
- 193-209
- ISSN
- 0193-953X (ISSN-L)
- OpenAlex
- W1977093186
- Cited by
- 18
- References
- 7
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Demensförbundet
- Stiftelsen Konsul Thure Carlssons Minne
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, early-onset dementia, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, progressive aphasia, genetic mutations, protein accumulation, neuropathology, pharmacotherapy, early diagnosis, caregiver support, symptom management
- MeSH terms
- C9orf72 Protein, Behavioral Symptoms, Diagnostic Errors, Humans, Microtubule-Associated Proteins, Middle Aged, Personality Assessment, Proteins, Psychiatric Status Rating Scales, Psychotropic Drugs, Frontotemporal Dementia, Neuroimaging
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