Neuroanatomy of Apathy and Disinhibition in Frontotemporal Lobar Degeneration
Open accessAbstract
OBJECTIVE: To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress. BACKGROUND: FTLD is a progressive neurodegenerative disease associated with behavioral disturbances. Group studies have related these behaviors to volume loss on MRI. METHODS: Forty caregivers of patients with the clinical diagnosis of FTLD completed the Neuropsychiatric Inventory. Twelve neuropsychiatric symptoms and the associated caregiver distress were assessed. Optimized voxel-based morphometry identified significant atrophy in subgroups of FTLD patients with isolated behavioral symptoms corresponding to the most distressing behaviors, and we correlated cortical atrophy directly with these distressing behavioral disorders in an unbiased group analysis. RESULTS: The greatest stressors for caregivers were apathy and disinhibition (p < 0.005 for both contrasts). Partially distinct areas of cortical atrophy were associated with these behaviors in both individual patients with these symptoms and group-wide analyses, including the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex in apathetic patients, and the medial orbital frontal cortex in disinhibited patients. CONCLUSIONS: Caregiver stress in families of FTLD patients is due in large part to apathy and disinhibition. The anatomic distribution of cortical loss corresponding to these distressing social behaviors includes partially distinct areas within the frontal lobe.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
People with frontotemporal dementia are more likely to experience frequent and serious BPSD.
“People with frontotemporal dementia are more likely to experience frequent and serious BPSD, e.g., agitation, disinhibition, apathy and eating abnormalities [125,126,127,128].”
From Relationship of Psychological Flexibility and Mindfulness to Caregiver Burden, and Depressive and Anxiety Symptoms in Caregivers of People with Dementia (2023) · cites this paper as [126]
The Introduction lists apathy, disinhibition and appetite changes in FTLD, and the Discussion says apathy was the most frequently observed symptom, with disinhibition nearly as common and abnormal eating fairly frequent. The Results also report severity scores and caregiver distress for these symptoms and agitation. The paper does not establish that people with FTLD are more likely than people with other dementias to experience frequent or serious behavioral symptoms. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Zhang, Y., Brady, M., & Smith, S. M. (2001) · IEEE Transactions on Medical Imaging · doi:10.1109/42.906424 · Cited by 7,628 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
Severe disturbance of higher cognition after bilateral frontal lobe ablation: Patient EVR
Eslinger, P. J., & Damasio, A. R. (1985) · Neurology · doi:10.1212/wnl.35.12.1731 · Cited by 1,426 · see citing works
The neural basis of human moral cognition
Moll, J., Zahn, R., de Oliveira-Souza, R., Krueger, F., & Grafman, J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1768 · Cited by 930 · cited 1× · see citing works
“We found mOFC disease in both disinhibited and apathetic subgroups. One possible account may be related to the anatomic extent of atrophy that is greater in the apathetic subgroup than the disinhibited subgroup. Clinically, we have observed that patients who are disinhibited can become apathetic over time. From this p…”
BackgroundDistinct behavioural profiles in frontotemporal dementia and semantic dementia
Snowden, J., Bathgate, D., Varma, A., Blackshaw, A., Gibbons, Z. C., & Neary, D. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.3.323 · Cited by 604 · see citing works
Bozeat, S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.178 · Cited by 603 · see citing works
Neuroanatomical correlates of behavioural disorders in dementia
Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. W., & Miller, B. L. (2005) · Brain · doi:10.1093/brain/awh628 · Cited by 497 · see citing works
Tranel, D., Bechara, A., & Denburg, N. L. (2002) · Cortex · doi:10.1016/s0010-9452(08)70024-8 · Cited by 441 · see citing works
Geodesic estimation for large deformation anatomical shape averaging and interpolation
Avants, B., & Gee, J. C. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.010 · Cited by 427 · see citing works
Self-citationSnowden, J. S., Neary, D., & Mann, D. M. A. (1996) · Churchill Livingstone eBooks · Cited by 341 · see citing works
The frontal behavioral inventory in the differential diagnosis of frontotemporal dementia
KERTESZ, A., NADKARNI, N., DAVIDSON, W., & THOMAS, A. W. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700644041 · Cited by 317 · see citing works
Behavioral disorders in the frontal and temporal variants of frontotemporal dementia
Liu, W., Miller, B. L., Kramer, J. H., Rankin, K., Wyss-Coray, C., Gearhart, R., Phengrasamy, L., Weiner, M., & Rosen, H. J. (2004) · Neurology · doi:10.1212/01.wnl.0000113729.77161.c9 · Cited by 313 · see citing works
Woolley, J. D., Gorno‐Tempini, M., Seeley, W. W., Rankin, K. P., Lee, S. S., Matthews, B. R., & Miller, B. L. (2007) · Neurology · doi:10.1212/01.wnl.0000277461.06713.23 · Cited by 254 · see citing works
Miller, B. L., Chang, L., Mena, I. G., Boone, K. B., & Lesser, I. M. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107324 · Cited by 206 · see citing works
Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementia
Miller, B. L., Darby, A. L., Benson, D. F., Cummings, J. L., & Miller, M. (1997) · The British Journal of Psychiatry · doi:10.1192/bjp.170.2.150 · Cited by 200 · see citing works
Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal Dementia
Peters, F., Perani, D., Herholz, K., Holthoff‐Detto, V., Beuthien‐Baumann, B., Sorbi, S., Pupi, A., Degueldre, C., Lemaire, C. F., Collette, F., et al. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000091898 · Cited by 190 · see citing works
Activities of daily living in frontotemporal dementia and Alzheimer disease
Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., & Hodges, J. R. (2007) · Neurology · doi:10.1212/01.wnl.0000264897.13722.53 · Cited by 188 · see citing works
Frontotemporal dementia: A review
Grossman, M. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702814357 · Cited by 182 · see citing works
Self-citationPrimary Progressive Aphasia: A Review
Grossman, M., & Ash, S. (2004) · Neurocase · doi:10.1080/13554790490960440 · Cited by 181 · see citing works
Self-citationSpectrum of anterior cerebral artery territory infarction: clinical and MRI findings
Kumral, E., Bayülkem, G., Evyapan, D., & Yünten, N. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.2002.00452.x · Cited by 176 · see citing works
Miller, M. I., Beg, M. F., Ceritoglu, C., & Stark, C. E. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503892102 · Cited by 173 · see citing works
Neural correlates of semantic and behavioural deficits in frontotemporal dementia
Williams, G. B., Nestor, P. J., & Hodges, J. R. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.023 · Cited by 168 · see citing works
The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia
Mychack, P., Kramer, J. H., Boone, K. B., & Miller, B. L. (2001) · Neurology · doi:10.1212/wnl.56.suppl_4.s11 · Cited by 168 · see citing works
Results of proton therapy of uveal melanomas treated in Nice
Courdi, A., Caujolle, J., Grange, J. D., Diallo-Rosier, L., Sahel, J., Bacin, F., Zur, C., Gastaud, P., Iborra-Brassart, N., Hérault, J., et al. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00147-9 · Cited by 140 · see citing works
Oops! Resolving social dilemmas in frontotemporal dementia
Eslinger, P. J., Moore, P., Troiani, V., Antani, S., Cross, K. A., Kwok, S., & Grossman, M. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.098228 · Cited by 136 · see citing works
Self-citationVBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
Whitwell, J. L., Sampson, E. L., Loy, C. T., Warren, J. E., Rossor, M. N., Fox, N. C., & Warren, J. D. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.006 · Cited by 130 · see citing works
Frontotemporal Dementia: Behavioral Symptoms and Caregiver Distress
Mourik, J. C., Rosso, S. M., Niermeijer, M. F., Duivenvoorden, H. J., Swieten, J. C. V., & Tibben, A. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080123 · Cited by 124 · see citing works
Neuropsychiatric Features of Frontotemporal Dementia
Mendez, M. F., & Perryman, K. M. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.4.424 · Cited by 110 · see citing works
Impact of Frontal Systems Behavioral Functioning in Dementia on Caregiver Burden
Davis, J. D., & Tremont, G. N. (2007) · Journal of Neuropsychiatry · doi:10.1176/jnp.2007.19.1.43 · Cited by 99 · see citing works
Distinct Antemortem Profiles in Patients With Pathologically Defined Frontotemporal Dementia
Grossman, M., Libon, D. J., Forman, M. S., Massimo, L. M., Wood, E. M., Moore, P., Anderson, C., Farmer, J. M., Chatterjee, A. K., Clark, C. M., et al. (2007) · Archives of Neurology · doi:10.1001/archneur.64.11.1601 · Cited by 94 · see citing works
Self-citationWhitwell, J. L., Jack, C. R., Baker, M., Rademakers, R., Adamson, J. L., Boeve, B. F., Knopman, D. S., Parisi, J. F., Petersen, R. C., Dickson, D. W., et al. (2007) · Archives of Neurology · doi:10.1001/archneur.64.3.371 · Cited by 82 · see citing works
Disruption of attention to novel events after frontal lobe injury in humans
Daffner, K. R. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.1.18 · Cited by 79 · see citing works
Treatment of Uveal Melanoma by Accelerated Proton Beam
Desjardins, L., Rouïc, L. L.-L., Lévy‐Gabriel, C., Cassoux, N., Dendale, R., Mazal, A., Delacroix, S., Sastre‐Garau, X., Plancher, C., & Asselain, B. J. R. (2011) · Developments in ophthalmology · doi:10.1159/000328257 · Cited by 72 · see citing works
Symmetric Data Attachment Terms for Large Deformation Image Registration
Beg, M. F., & KHAN, A. R. (2007) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2007.898813 · Cited by 69 · see citing works
Dementia of frontal type and the focal lobar atrophies
Gregory, C. A., & Hodges, J. R. (1993) · International Review of Psychiatry · doi:10.3109/09540269309037801 · Cited by 46 · see citing works
Hidden Markov random field model for segmentation of brain MR image
Zhang, Y., Brady, J. M., & Smith, S. M. (2000) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.387617 · Cited by 42 · see citing works
Gallo, J. L., Schmidt, K. S., & Libon, D. J. (2008) · Dementia · doi:10.1177/1471301208093291 · Cited by 15 · see citing works
Self-citationTran, B. K., Schalenbourg, A., BOVEY, E. H., Zografos, L., & Wolfensberger, T. J. (2013) · Retina · doi:10.1097/iae.0b013e318295f758 · Cited by 13 · see citing works
Hidden Markov random field model for segmentation of brain MR images
Zhang, Y., Brady, M., & Smith, S. M. (2000) · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [15]Avants B, Anderson C, Grossman M, Gee JC: Symmetric normalization for patient-specific tracking of longitudinal change in frontotemporal dementia. Med Image Anal, in press.
- [37]Grossman M, Libon DJ, Forman MS, Massimo L, Wood E, Moore P, Anderson C, Farmer J, Chatterjee A, Clark CM, Coslett HB, Hurtig HI, Lee VM, Trojanowski JQ. Distinct antemortem profiles in pathologically defined patients with frontotemporal dementia. Arch Neurol. 2007;64:1601–1609. doi: 10.1001/archneur.64.11.1601. [DOI] [PubMed] [Google Scholar] · DOI
Cited by
Sorted by citations
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Self-citationBehavioral and psychological symptoms of dementia
Cerejeira, J., Lagarto, L., & Mukaetova-Ladinska, E. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00073 · Cited by 1,425 · see citing works
Advanced Normalization Tools (ANTs)
Avants, B. (2020) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.5138159 · Cited by 982 · see citing works
Self-citationDementia Caregiver Burden: a Research Update and Critical Analysis
Cheng, S.-T. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0818-2 · Cited by 595 · see citing works
Advanced Normalization Tools: V1.0
Avants, B., Tustison, N. J., & Song, G. (2009) · The Insight Journal · doi:10.54294/uvnhin · Cited by 559 · see citing works
Self-citationWhitwell, J. L., Przybelski, S. A., Weigand, S. D., Ivnik, R. J., Vemuri, P., Gunter, J. L., Senjem, M. L., Shiung, M. M., Boeve, B. F., Knopman, D. S., et al. (2009) · Brain · doi:10.1093/brain/awp232 · Cited by 306 · see citing works
Healey, M. L., & Grossman, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00491 · Cited by 219 · see citing works
Self-citationLEVENSON, R. W., Sturm, V. E., & Haase, C. M. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153653 · Cited by 193 · see citing works
Diagnostic criteria for apathy in neurocognitive disorders
Miller, D. S., Robert, P., Ereshefsky, L., Adler, L., Bateman, D., Cummings, J., Dekosky, S., Fischer, C. E., Husain, M., Ismail, Z., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12358 · Cited by 168 · see citing works
Eslinger, P. J., Moore, P., Anderson, C., & Grossman, M. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.1.74 · Cited by 184 · see citing works
Self-citationDeterminants of behavioral and psychological symptoms of dementia: A scoping review of the evidence
Kolanowski, A., Boltz, M., Galik, E., Gitlin, L. N., Kales, H. C., Resnick, B., Van Haitsma, K. S., Knehans, A., Sutterlin, J. E., Sefcik, J. S., et al. (2017) · Nursing Outlook · doi:10.1016/j.outlook.2017.06.006 · Cited by 165 · see citing works
Self-citationApathy in Neuropsychiatric Disease: Diagnosis, Pathophysiology, and Treatment
Chase, T. N. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9196-9 · Cited by 141 · see citing works
Apathy in Frontotemporal Dementia: Behavioral and Neuroimaging Correlates
Eslinger, P. J., Moore, P., Antani, S., Anderson, C., & Grossman, M. (2012) · Behavioural Neurology · doi:10.1155/2012/286427 · Cited by 131 · see citing works
Self-citationPhenomenology and anatomy of abnormal behaviours in primary progressive aphasia
Rohrer, J. D., & Warren, J. D. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.03.012 · Cited by 129 · see citing works
Johnen, A., & Bertoux, M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00594 · Cited by 102 · see citing works
Gainotti, G. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00055 · Cited by 101 · see citing works
Neural Correlates for Apathy: Frontal-Prefrontal and Parietal Cortical- Subcortical Circuits
Moretti, R., & Signori, R. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00289 · Cited by 99 · see citing works
Irwin, D. J., Trojanowski, J. Q., & Grossman, M. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00006 · Cited by 96 · see citing works
Self-citationStanton, B. R., Leigh, P. N., Howard, R. J., Barker, G. J., & Brown, R. G. (2013) · Journal of Neurology · doi:10.1007/s00415-013-6989-9 · Cited by 92 · see citing works
Pan, P. L., Song, W., Yang, J., Huang, R., Chen, K., Gong, Q. Y., Zhong, J. G., Shi, H. C., & Shang, H. F. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000338176 · Cited by 90 · see citing works
Bertoux, M., Emmanuelle Volle, C., Funkiewiez, A., de Souza, L. C., Leclercq, D., & Dubois, B. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712001300 · Cited by 85 · see citing works
A Multidimensional Approach to Apathy after Traumatic Brain Injury
Arnould, A., Rochat, L., Azouvi, P., & der Linden, M. V. (2013) · Neuropsychology Review · doi:10.1007/s11065-013-9236-3 · Cited by 79 · see citing works
Avants, B., Libon, D. J., Rascovsky, K., Boller, A., McMillan, C. T., Massimo, L. M., Coslett, H. B., Chatterjee, A. K., Gross, R. G., & Grossman, M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.09.048 · Cited by 78 · see citing works
Self-citationAsymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia
Irwin, D. J., McMillan, C. T., Xie, S. X., Rascovsky, K., Deerlin, V. M. V., Coslett, H. B., Hamilton, R. H., Aguirre, G. K., Lee, E. B., Lee, V. M. ‐., et al. (2017) · Brain · doi:10.1093/brain/awx319 · Cited by 74 · see citing works
Self-citationMerrilees, J. J., Klapper, J., Murphy, J. M., Lomen, C. E., & Miller, B. L. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482961003605788 · Cited by 76 · see citing works
Merrilees, J. J., Dowling, G. A., Hubbard, E. M., Mastick, J., Ketelle, R., & Miller, B. L. (2012) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182471c54 · Cited by 75 · see citing works
Clinicopathological correlates of behavioral and psychological symptoms of dementia
Casanova, M. F., STARKSTEIN, S. E., & Jellinger, K. A. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0821-3 · Cited by 73 · see citing works
Grossman, M., Eslinger, P. J., Troiani, V., Anderson, C., Avants, B., Gee, J. C., McMillan, C. T., Massimo, L. M., Khan, A., & Antani, S. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.07.036 · Cited by 72 · see citing works
Self-citationApathy: A neurocircuitry model based on frontotemporal dementia
Ducharme, S., Price, B. H., & Dickerson, B. C. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316277 · Cited by 69 · see citing works
Apathy in Frontotemporal Degeneration: Neuroanatomical Evidence of Impaired Goal-directed Behavior
Massimo, L., Powers, J. P., Evans, L. K., McMillan, C. T., Rascovsky, K., Eslinger, P., Ersek, M., Irwin, D. J., & Grossman, M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00611 · Cited by 69 · see citing works
Self-citationLife Enhancing Activities for Family Caregivers of People With Frontotemporal Dementia
Dowling, G. A., Merrilees, J., Mastick, J., Chang, V. Y., Hubbard, E., & Moskowitz, J. T. (2014) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182a6b905 · Cited by 69 · see citing works
Caring for loved ones with frontotemporal degeneration: The lived experiences of spouses
Massimo, L. M., Evans, L. K., & Benner, P. (2013) · Geriatric Nursing · doi:10.1016/j.gerinurse.2013.05.001 · Cited by 67 · see citing works
Self-citationAreas of Brain Damage Underlying Increased Reports of Behavioral Disinhibition
Knutson, K. M., Monte, O. D., Schintu, S., Wassermann, E. M., Raymont, V., Grafman, J. H., & Krüeger, F. (2015) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.14060126 · Cited by 64 · see citing works
Neuroimaging findings in frontotemporal lobar degeneration spectrum of disorders
Agosta, F., Canu, E., Sarro, L., Comı, G., & Filippi, M. (2011) · Cortex · doi:10.1016/j.cortex.2011.04.012 · Cited by 62 · see citing works
Automatic measurement of prosody in behavioral variant FTD
Nevler, N., Ash, S., Jester, C., Irwin, D. J., Liberman, M., & Grossman, M. (2017) · Neurology · doi:10.1212/wnl.0000000000004236 · Cited by 61 · see citing works
Self-citationCerami, C., Dodich, A., Lettieri, G., Iannaccone, S., Magnani, G., Marcone, A., Gianolli, L., Cappa, S. F., & Perani, D. (2016) · Cortex · doi:10.1016/j.cortex.2016.07.008 · Cited by 61 · see citing works
O’Connor (2017) · doi:10.1212/wnl.0000000000004215 · Cited by 60 · see citing works
Robinson, H. M., Calamia, M. R., Gläscher, J. P., Bruss, J., & Tranel, D. (2013) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771300060x · Cited by 60 · see citing works
Immoral behaviour following brain damage: A review
Roberts, S., Henry, J. D., & Molenberghs, P. (2018) · Journal of Neuropsychology · doi:10.1111/jnp.12155 · Cited by 58 · see citing works
Möller, C., Dieleman, N., van der Flier, W. M., Versteeg, A., Pijnenburg, Y. A. L., Scheltens, P., Barkhof, F., & Vrenken, H. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141230 · Cited by 58 · see citing works
Krueger, C. E., Laluz, V., Rosen, H. J., Neuhaus, J. M., Miller, B. L., & Kramer, J. H. (2011) · Neuropsychology · doi:10.1037/a0021681 · Cited by 58 · see citing works
Apathy and Dementia. Nosology, Assessment and Management
Cipriani, G., Lucetti, C., Danti, S., & Nuti, A. (2014) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000190 · Cited by 55 · see citing works
Massimo, L. M., Kales, H. C., & Kolanowski, A. M. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15343 · Cited by 57 · see citing works
Self-citationCognitive and behavioural inhibition deficits in neurodegenerative dementias
Migliaccio, R., Tanguy, D., Bouzigues, A., Sezer, I., Dubois, B., Ber, I. L., Batrancourt, B., Godefroy, V., & Lévy, R. (2020) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2020.08.001 · Cited by 48 · see citing works
Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries
Knutson, K. M., Monte, O. D., Raymont, V., Wassermann, E. M., Krüeger, F., & Grafman, J. H. (2013) · Human Brain Mapping · doi:10.1002/hbm.22225 · Cited by 54 · see citing works
Wei, G., Irish, M., Hodges, J. R., Piguet, O., & Kumfor, F. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09679-1 · Cited by 54 · see citing works
FTD spectrum: Neuroimaging across the FTD spectrum
Whitwell, J. L. (2019) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2019.05.009 · Cited by 53 · see citing works
Effort avoidance as a core mechanism of apathy in frontotemporal dementia
Bouc, R. L., Borderies, N., Carle, G., Robriquet, C., Vinckier, F., Jean Daunizeau, A., Azuar, C., Lévy, R., & Pessiglione, M. (2022) · Brain · doi:10.1093/brain/awac427 · Cited by 53 · see citing works
Updating the role of dopamine in human motivation and apathy
Chong, T. T. ‐. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.010 · Cited by 50 · see citing works
Raghavan, S., Bineesh, C., Varghese, T., Kesavadas, C., Verghese, J., & Mathuranath, P. S. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00150-3 · Cited by 51 · see citing works
Recent Advances in the Imaging of Frontotemporal Dementia
Whitwell, J. L., & Josephs, K. A. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0317-0 · Cited by 50 · see citing works
Borroni, B., Grassi, M., Premi, E., Gazzina, S., Alberici, A., Cosseddu, M., Paghera, B., & Padovani, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.003 · Cited by 49 · see citing works
Onoda, K., & Yamaguchi, S. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.07.030 · Cited by 47 · see citing works
Fernández‐Matarrubia, M., Matías‐Guiu, J. A., Cabrera‐Martín, M. N., Moreno‐Ramos, T., Valles‐Salgado, M., Carreras, J. L., & Matías‐Guiu, J. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4695 · Cited by 45 · see citing works
UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis
Placek, K., Baer, G. M., Elman, L. B., McCluskey, L. F., Hennessy, L., Ferraro, P. M., Lee, E. B., Lee, V. M. ‐., Trojanowski, J. Q., Deerlin, V. M. V., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.031 · Cited by 43 · see citing works
Self-citationPowers, J., Massimo, L. M., McMillan, C. T., Yushkevich, P. A., Zhang, H. G., Gee, J. C., & Grossman, M. (2014) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000044 · Cited by 43 · see citing works
Self-citationCerebral correlates of psychotic syndromes in neurodegenerative diseases
Jellinger, K. A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01311.x · Cited by 43 · see citing works
Quaranta, D., Marra, C., Rossi, C., Gainotti, G., & Masullo, C. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/719250 · Cited by 42 · see citing works
Automated analysis of lexical features in frontotemporal degeneration
Cho, S., Nevler, N., Ash, S., Shellikeri, S., Irwin, D. J., Massimo, L., Rascovsky, K., Olm, C., Grossman, M., & Liberman, M. (2021) · Cortex · doi:10.1016/j.cortex.2021.01.012 · Cited by 41 · see citing works
Self-citationTorrisi, M., Cacciola, A., Marra, A., Luca, R. D., Bramanti, P., & Calabrò, R. S. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12854 · Cited by 40 · see citing works
A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia
Jenkins, L. M., Wang, L., Rosen, H. J., & Weıntraub, S. (2022) · Brain · doi:10.1093/brain/awac133 · Cited by 38 · see citing works
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
Magrath Guimet, N., Miller, B. L., Allegri, R. F., & Rankin, K. P. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.707799 · Cited by 38 · see citing works
Virani, K., Jesso, S., KERTESZ, A. E., Mitchell, D. G. V., & Finger, E. C. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120008 · Cited by 38 · see citing works
Raimo, S., Santangelo, G., D’Iorio, A., Trojano, L., & Grossi, D. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9959-0 · Cited by 37 · see citing works
White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes
Lansdall, C. J., Coyle-Gilchrist, I. T. S., Jones, P. S., Rodríguez, P. V., Wilcox, A., Wehmann, E., Dick, K. M., Robbins, T. W., & Rowe, J. B. (2018) · Neurology · doi:10.1212/wnl.0000000000005175 · Cited by 36 · see citing works
Atrophy network mapping of clinical subtypes and main symptoms in frontotemporal dementia
Chu, M., Jiang, D., Li, D., Yan, S., Liu, L., Nan, H., Wang, Y., Wang, Y., Yue, A., Ren, L., et al. (2024) · Brain · doi:10.1093/brain/awae067 · Cited by 35 · see citing works
Differentiating Subtypes of Apathy to Improve Person-Centered Care in Frontotemporal Degeneration
Massimo, L. M., Evans, L. K., & Grossman, M. (2014) · Journal of Gerontological Nursing · doi:10.3928/00989134-20140827-01 · Cited by 35 · see citing works
Self-citationFirst Symptoms and Neurocognitive Correlates of Behavioral Variant Frontotemporal Dementia
Santamaría‐García, H. A., Reyes, P. A., García, A. M., Báez, S., Martínez, Á. V., Escudero, J. M. S., Slachevsky, A., Sigman, M., Matallana, D., & Ibáñez, A. M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160501 · Cited by 33 · see citing works
A Clinical Guide to Frontotemporal Dementias
Ljubenkov, P. A., & Miller, B. L. (2016) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20160018 · Cited by 32 · see citing works
Mariano, L. I., O’Callaghan, C., Guimarães, H. C., Gambogi, L. B., da Silva, T. B. L., Yassuda, M. S., Amaral, J. S., Caramelli, P., Hornberger, M., Teixeira, A. L., et al. (2019) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617719000973 · Cited by 32 · see citing works
Beyond cognitive reserve: Behavioural reserve hypothesis in Frontotemporal Dementia
Premi, E., Garibotto, V., Gazzina, S., Grassi, M., Cosseddu, M., Paghera, B., Turla, M., Padovani, A., & Borroni, B. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.030 · Cited by 31 · see citing works
Olabi, B., Ellison-Wright, I., Bullmore, E. T., & Lawrie, S. M. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-104 · Cited by 31 · see citing works
Exploring social cognition in patients with apathy following acquired brain damage
Njomboro, P., Humphreys, G. W., & Deb, S. S. (2014) · BMC Neurology · doi:10.1186/1471-2377-14-18 · Cited by 30 · see citing works
Gonçalves, S. D. A. B., Caramelli, P., Mariano, L. I., Guimarães, H. C., Gambogi, L. B., Resende, E. D. P. F., Teixeira, A. L., & de Souza, L. C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146799 · Cited by 29 · see citing works
Positive behaviour support in frontotemporal dementia: a pilot study
O’Connor, C. M. C., Mioshi, E., Kaizik, C., Fisher, A., Hornberger, M., & Piguet, O. (2021) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2019.1707099 · Cited by 29 · see citing works
Healey, M. L., McMillan, C. T., Golob, S., Spotorno, N., Rascovsky, K., Irwin, D. J., Clark, R., & Grossman, M. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.01.028 · Cited by 28 · see citing works
Self-citationGait and Apathy as Relevant Symptoms of Subcortical Vascular Dementia
Moretti, R., Cavressi, M., & Tomietto, P. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317514550329 · Cited by 27 · see citing works
Eldaief, M. C., Brickhouse, M. J., Katsumi, Y., Rosen, H. J., Carvalho, N., Touroutoglou, A., & Dickerson, B. C. (2023) · Brain · doi:10.1093/brain/awad167 · Cited by 24 · see citing works
Serra, L., Cercignani, M., Carlesimo, G. A., Fadda, L., Tini, N., Giulietti, G., Caltagirone, C., & Bozzali, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064578 · Cited by 25 · see citing works
Overcoming apathy in frontotemporal dementia: challenges and future directions
Johnson, E., & Kumfor, F. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.022 · Cited by 22 · see citing works
Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights
Scarioni, M., Gami‐Patel, P., Peeters, C. F. W., de Koning, F., Seelaar, H., Mol, M. O., Swieten, J. C. V., Bank, N. B., Rozemüller, A. J. M., Hoozemans, J. J. M., et al. (2022) · Brain · doi:10.1093/brain/awac043 · Cited by 24 · see citing works
Otero, M. C., & Levenson, R. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000468146 · Cited by 20 · see citing works
Tan, K. P., Ang, J. K., Koh, E. B. Y., Pang, N. T. P., & Mat Saher, Z. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054232 · Cited by 23 · see citing works
Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease
Nakaaki, S., Banno, K., Sato, J., Torii, K., Narumoto, J., Miyata, J., Hirono, N., Furukawa, T. A., Mimura, M., & Akechi, T. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s57522 · Cited by 21 · see citing works
Grey and White Matter Clinico-Anatomical Correlates of Disinhibition in Neurodegenerative Disease
Santillo, A. F., Lundblad, K., Nilsson, M., Waldö, M. L., van Westen, D., Lätt, J., Nordström, E., Vestberg, S., Lindberg, O. E., & Nilsson, C. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164122 · Cited by 21 · see citing works
Paholpak, P., Carr, A. R., Barsuglia, J. P., Barrows, R. J., Jimenez, E. E., Lee, G. J., & Mendez, M. F. (2016) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988716666377 · Cited by 20 · see citing works
Chapman, K. R., Tremont, G. N., Malloy, P. F., & Spitznagel, M. B. (2019) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719856688 · Cited by 20 · see citing works
Exploration Deficits Under Ecological Conditions as a Marker of Apathy in Frontotemporal Dementia
Batrancourt, B., Lecouturier, K., Ferrand-Verdejo, J., Guillemot, V., Azuar, C., Bendetowicz, D., Migliaccio, R., Rametti‐Lacroux, A., Dubois, B., & Lévy, R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00941 · Cited by 23 · see citing works
Coleman, K. K. L., Berry, S. M., Cummings, J. L., Hsiung, G. R., Laforce, R. J., Huey, E. D., Ducharme, S., Tartaglia, M. C., Mendez, M. F., Onyike, C. U., et al. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00456-3 · Cited by 19 · see citing works
Basavaraju, R., Feng, X., France, J., Huey, E. D., & Provenzano, F. A. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720964258 · Cited by 18 · see citing works
The Neuropsychiatric Features of Behavioral Variant Frontotemporal Dementia
Peet, B. T., Castro‐Suárez, S., & Miller, B. L. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_2 · Cited by 17 · see citing works
Regional prefrontal cortical atrophy predicts specific cognitive-behavioral symptoms in ALS-FTD
Ratti, E., Domoto‐Reilly, K., Caso, C., Murphy, A., Brickhouse, M. J., Hochberg, D., Makris, N., Cudkowicz, M., & Dickerson, B. C. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00456-1 · Cited by 17 · see citing works
Prefrontal cortical thickness in motor neuron disease
Machts, J., Cárdenas‐Blanco, A., Acosta‐Cabronero, J., Kaufmann, J., Loewe, K., Kasper, E., Schuster, C., Prudlo, J., Vielhaber, S., & Nestor, P. J. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.03.002 · Cited by 17 · see citing works
Gray Matter Vulnerabilities Predict Longitudinal Development of Apathy in Huntington's Disease
Paepe, A. E. D., Ara, A., García-Gorro, C., Martínez-Horta, S., Pèrez-Pèrez, J., Kulisevsky, J., Rodríguez-Dechicha, N., Vaquer, I., Subirà, S., Calopa, M., et al. (2021) · Movement Disorders · doi:10.1002/mds.28638 · Cited by 14 · see citing works
Waldö, M. L. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.02.001 · Cited by 18 · see citing works
Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates
Rouse, M., Husain, M., Garrard, P., Patterson, K., Rowe, J., & Ralph, M. L. (2024) · medRxiv · doi:10.1093/brain/awaf061 · Cited by 15 · see citing works
Yan, H., Wu, H., Cai, Z., Du, S., Li, L., Xu, B., Chang, C., & Wang, N. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1181558 · Cited by 15 · see citing works
Symptoms of apathy and passivity in dementia: A simultaneous concept analysis
Gilmore‐Bykovskyi, A. L., Block, L., Johnson, R. E., & Goris, E. D. (2018) · Journal of Clinical Nursing · doi:10.1111/jocn.14663 · Cited by 16 · see citing works
Frontotemporal dementia subtypes based on behavioral inhibition deficits
Godefroy, V., Tanguy, D., Bouzigues, A., Sezer, I., Ferrand-Verdejo, J., Azuar, C., Bendetowicz, D., Carle, G., Rametti‐Lacroux, A., Bombois, S., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/dad2.12178 · Cited by 15 · see citing works
Racial Differences in Clinical Presentation in Individuals Diagnosed With Frontotemporal Dementia
Jin, H. A., McMillan, C. T., Yannatos, I., Fisher, L., Rhodes, E., Jacoby, S. F., Irwin, D. J., & Massimo, L. M. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.3093 · Cited by 14 · see citing works
Self-citation
- Authors
- Massimo, L., Powers, C., Moore, P., Vesely, L., Avants, B., Gee, J., Libon, D. J., & Grossman, M.
- Affiliations
- University of Pennsylvania (US)
- Drexel University (US)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2009
- Volume
- 27
- Issue
- 1
- Pages
- 96-104
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC2820577
- OpenAlex
- W2169733225
- Cited by
- 156
- References
- 46
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 12 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 11
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NS53488, AG 17586, AG15116)
- National Institute on Aging (AG15116, R01AG015116, P01AG017586, AG17586)
- National Institute of Neurological Disorders and Stroke (NS53488, NS-44266, P50NS053488, R01NS044266)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- frontotemporal lobar degeneration, apathy, disinhibition, caregiver distress, neuropsychiatric symptoms, cortical atrophy, voxel-based morphometry, dorsal anterior cingulate cortex, dorsolateral prefrontal cortex, frontal lobe, behavioral symptoms
- MeSH terms
- Aged, Behavior, Brain, Dementia, Female, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Stress, Psychological, Caregivers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
