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Associations between sedentary behaviour and metabolic parameters in patients with schizophrenia
Abstract
This study examined the association between sedentary behaviour and metabolic parameters among patients with schizophrenia. A total of 76 patients and 38 healthy age-, gender- and BMI-matched volunteers were included. Participants were asked for their overall sitting and physical activity behaviour using the International Physical Activity Questionnaire. Patients were additionally screened for psychiatric symptoms and extrapyramidal side-effects of antipsychotic medication. On average, patients with schizophrenia spent 8.5h per day sitting (versus 6.21h in healthy controls). Patients sitting more than 10.4h per day had a higher BMI, waist circumference and fasting glucose concentrations and experienced more negative and cognitive symptoms than those sitting less than 5.8h per day. Overall sitting time was associated with a significantly greater likelihood of metabolic syndrome. A stepwise backward-elimination multivariate regression analysis demonstrated that sitting time is a significant predictor for BMI. Current results suggest patients with schizophrenia may benefit from reducing total sitting time.
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“Thus, other diagnosticindependent factors likely influence T2DM frequency, including hyperglycaemia following psychotropic medication use 26 and long-term exposure to unhealthy lifestyle behaviors 27,28 , as well as potential genetic factors linking psychiatric and medical risk 29 .”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [27]
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Metadata
- Authors
- Vancampfort, D., Probst, M., Knapen, J., Carraro, A., & De Hert, M.
- Affiliations
- KU Leuven (BE)
- University of Padua (IT)
- Corresponding author
- Vancampfort, Davy
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 200
- Issue
- 2-3
- Pages
- 73-78
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2155434312
- Cited by
- 149
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 17 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 7 · 2018: 20 · 2017: 15 · 2016: 19 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 3
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- sedentary behavior, sitting time, schizophrenia, metabolic parameters, metabolic syndrome, body mass index, waist circumference, fasting blood glucose, physical activity, negative symptoms, cognitive symptoms, antipsychotic adverse effects, extrapyramidal symptoms
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Motor Activity, Surveys and Questionnaires, Risk Factors, Schizophrenia, Antipsychotic Agents, Body Mass Index, Metabolic Syndrome, Waist Circumference, Sedentary Behavior
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