The DOI matches its Crossref record; 154 of the 156 references it cites were found in a registry or an index.
A systematic review of factors influencing adherence to antipsychotic medication in schizophrenia-spectrum disorders
Abstract
Adherence to antipsychotics improves outcome in schizophrenia. There is a lack of consensus on which factors most influence adherence behaviour and methodological issues hinder interpretation of existing evidence. A rigorous systematic search designed to identify robustly implicated factors emerging from methodologically rigorous studies narrowed our search to 13 observational studies (total N=6235) relating to adherence, antipsychotics and schizophrenia. Studies varied significantly, with reported adherence rates ranging from 47.2% to 95%. Positive attitude to medication and illness insight were the only factors consistently associated with better adherence, while contradictory results were found for socio-demographic characteristics, symptom severity and side effects. Only distinct aspects of the therapeutic relationship and social support in younger patients were related to good adherence. Antipsychotic type or formulation and neurocognitive functioning did not appear to impact medication adherence. Despite greater methodological rigour in determining studies to include in the present systematic review, it remains difficult to guide clinicians in this vital area and most of the work discussed contained small sample sizes. Future research in this field should therefore prioritise prospective study designs over longer periods and larger samples in naturalistic settings, providing a more appropriate and clinically meaningful framework than widely used cross-sectional designs.
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“In such scenario, SDM is certainly an interesting approach to achieve greater knowledge of LAIs and acceptance on behalf of patients and families [35, 36].”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [36]
In the citing paper
“However, the adoption of SDM appears useful in the long-term treatment of patients with schizophrenia where medication non-adherence plays an important role in relapse rates, poor outcome, and high costs [36]”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [36]
In the citing paper
“However, the adoption of SDM appears useful in the long-term treatment of patients with schizophrenia where medication non-adherence plays an important role in relapse rates, poor outcome, and high costs [36]”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [36]
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Metadata
- Authors
- Sendt, K.-V., Tracy, D. K., & Bhattacharyya, S.
- Affiliations
- King's College London (GB)
- Oxleas NHS Foundation Trust (GB)
- Corresponding author
- Bhattacharyya, Sagnik
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 225
- Issue
- 1-2
- Pages
- 14-30
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2068456588
- Cited by
- 245
- References
- 156
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 16 · 2023: 20 · 2022: 16 · 2021: 21 · 2020: 36 · 2019: 27 · 2018: 20 · 2017: 18 · 2016: 19 · 2015: 10
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Medical Research Council, UK (MR/J012149/1)
- National Institute of Health Research (NIHR) (NIHR CS-11-001)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- medication adherence, antipsychotic drugs, schizophrenia spectrum disorders, treatment adherence factors, insight into illness, therapeutic relationship, social support, adverse effects, symptom severity, neurocognitive function
- MeSH terms
- Adult, Attitude to Health, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Medication Adherence
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