FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression

Bryushkova, Lyubov; Zai, Clement; Chen, Sheng; Pappa, Irene; Mileva, Viara; Tiemeier, Henning; Bakermans-Kranenburg, Marian; Kennedy, James L.; Beitchman, Joseph H.

doi:10.1016/j.psychres.2015.09.052

Cited by 13Child Abuse and TraumaChild and Adolescent Psychosocial and Emotional DevelopmentNeurotransmitter Receptor Influence on Behavior

FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression

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Bryushkova, Lyubov, Zai, Clement, Chen, Sheng, Pappa, Irene, Mileva, Viara, Tiemeier, Henning, Bakermans-Kranenburg, Marian, Kennedy, James L. +1 more·2016·Psychiatry Research

DOI 10.1016/j.psychres.2015.09.052

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Abstract

Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.

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There was a gene-environment interaction: rs4713916 A-carriers with maltreatment had highest scores.
“GxE: rs4713916 A-carriers with maltreatment had highest scores”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Bryushkova [103]
There was no significant case-control association for CBCL aggression.
“NS: case-control, CBCL aggression”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Bryushkova [103]

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Authors: Bryushkova, L., Zai, C., Chen, S., Pappa, I., Mileva, V., Tiemeier, H., Bakermans-Kranenburg, M., Kennedy, J. L., & Beitchman, J. H.
Affiliations: University of Toronto (CA)
Centre for Addiction and Mental Health (CA)
Erasmus MC (NL)
Corresponding author: Bryushkova, Lyubov
ORCID: Zai, Clement
Pappa, Irene
Tiemeier, Henning
Kennedy, James L.
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2016-08
Volume: 242
Pages: 277-280
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2015.09.052
OpenAlex: W2415284423
Cited by: 13
References: 35
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2018: 4 · 2017: 2
FWCI: 2.67
Type: journal article
Language: en
Open access: green
www.sciencedirect.com
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: FKBP5, child abuse, aggression, genetic polymorphism, externalizing traits, anxiety, stress response, gene-environment interaction, child psychopathology
MeSH terms: Tacrolimus Binding Protein 5, Aggression, Anxiety, Child, Child Abuse, Female, Genotype, Humans, Male, Polymorphism, Genetic, Genetic Variation, Case-Control Studies, Polymorphism, Single Nucleotide, Tacrolimus Binding Proteins, Gene-Environment Interaction

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FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression

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