CoChat
Sign Up
Cited by 562Stress Responses and CortisolMemory and Neural MechanismsMemory Processes and Influences

The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.

Stress hormones and human memory function across the lifespan

Lupien, Sonia J., Fiocco, Alexandra, Wan, Nathalie, Maheu, Francoise, Lord, Catherine, Schramek, Tania, Tu, Mai Thanh·2005·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2004.08.003
Open this paper in CoChat — free account

Abstract

In this paper, we summarize the data obtained in our laboratory showing the effects of glucocorticoids on human cognitive function in older adults, young adults and children. We first present data obtained in the aged human population which showed that long-term exposure to high endogenous levels of glucocorticoids is associated with both memory impairments and a 14% smaller volume of the hippocampus. We then report on studies showing that in older adults with moderate levels of glucocorticoids, memory performance can be acutely modulated by pharmacological manipulations of glucocorticoids. In young adults, we present data obtained in our laboratory showing that cognitive processing sustained by the frontal lobes is also sensitive to acute increases of glucocorticoids. We also summarize studies showing that just as in older adults, memory performance in young adults can be acutely modulated by pharmacological manipulations of glucocorticoids. We then present a study in which we showed a differential involvement of adrenergic and glucocorticoid hormones for short- and long-term memory of neutral and emotional information. In the last section of the paper, we present data obtained in a population of young children and teenagers from low and high socioeconomic status (SES), where we showed that children from low SES present significantly higher levels of basal cortisol when compared to children from high SES. We then present new data obtained in this population showing that children and teenagers from low and high SES do not process the plausibility of positive and negative attributes in the same way. Children from low SES tended to process positive and negative attributes on a more negative note than children from high SES, and this type of processing was significantly related to basal cortisol at age 10, 12 and 14. Altogether, the results of these studies show that both bottom-up (effects of glucocorticoids on cognitive function), and top-down (effects of cognitive processing on glucocorticoid secretion) effects exist in the human population.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.psyneuen.2004.08.003

Cites

117 of 117 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 115 references

Research works printed but not linked: 3

  1. Chrousos, 1988, Glucocorticoids and glucocorticoids antagonist: lesson from RU 486, Kidney Int., 34, S18
  2. Lupien, 1993, All things being otherwise unequal: reflection on the increased inter-individual differences in cognitive function during human aging, Rev. de Neuropsychol., 3, 3
  3. Scolville, 1957, Hippocampal damage and memory dysfunction, J. Neurol. Psychiatry, 20, 11

Cited by

Sorted by citations

Items 501–560 of 560

Related

See all

Metadata

Authors
Lupien, S. J., Fiocco, A., Wan, N., Maheu, F., Lord, C., Schramek, T., & Tu, M. T.
Affiliations
Douglas Mental Health University Institute (CA)
Corresponding author
Lupien, Sonia J.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2005-04
Volume
30
Issue
3
Pages
225-242
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2004.08.003
OpenAlex
W2008112018
Cited by
562
References
115
Citations by year
2026: 6 · 2025: 16 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 30 · 2020: 19 · 2019: 30 · 2018: 30 · 2017: 18 · 2016: 30 · 2015: 35 · 2014: 33 · 2013: 29 · 2012: 35
FWCI
10.19
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
glucocorticoids, stress hormones, memory, hippocampal volume, aging, cortisol, socioeconomic status, children, adolescents, emotional memory, cognitive processes, frontal lobe, top-down effects, bottom-up effects
MeSH terms
Adolescent, Adult, Aged, Aging, Animals, Child, Cognition, Frontal Lobe, Glucocorticoids, Hippocampus, Humans, Memory, Middle Aged, Organ Size, Stress, Physiological, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review