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Cited by 1,204Stress Responses and CortisolAdrenal Hormones and DisordersFibromyalgia and Chronic Fatigue Syndrome Research

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A new view on hypocortisolism

Fries, Eva, Hesse, Judith, Hellhammer, Juliane, Hellhammer, Dirk H.·2005·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2005.04.006
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Abstract

Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and post-traumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisolism may occur after a prolonged period of hyperactivity of the hypothalamic-pituitary-adrenal axis due to chronic stress as illustrated in an animal model. Further evidence suggests that despite symptoms such as pain, fatigue and high stress sensitivity, hypocortisolism may also have beneficial effects on the organism. This assumption will be underlined by some studies suggesting protective effects of hypocortisolism for the individual.

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Metadata

Authors
Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H.
Affiliations
Universität Trier (DE)
Corresponding author
Hellhammer, Dirk H.
ORCID
Hellhammer, Dirk H.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2005-11
Volume
30
Issue
10
Pages
1010-1016
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2005.04.006
OpenAlex
W1968787277
Cited by
1,204
References
8
Citations by year
2026: 30 · 2025: 39 · 2024: 41 · 2023: 39 · 2022: 62 · 2021: 67 · 2020: 73 · 2019: 60 · 2018: 72 · 2017: 70 · 2016: 58 · 2015: 72 · 2014: 79 · 2013: 80 · 2012: 76
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
adrenal insufficiency, chronic stress, hypothalamic-pituitary-adrenal axis, chronic fatigue syndrome, fibromyalgia, post-traumatic stress disorder, stress sensitivity, pain, fatigue
MeSH terms
Humans, Hydrocortisone, Immune System, Stress, Psychological, Sympathetic Nervous System

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