Postprandial prolactin suppression appears absent in antipsychotic-treated male patients
Open accessAbstract
INTRODUCTION: Hyperprolactinemia is a common side-effect of antipsychotic treatment. Antipsychotics and hyperprolactinemia are both considered risk factors of metabolic disturbances and diabetes. Investigations on prolactin response to meal ingestion in antipsychotic-treated patients are missing. MATERIAL AND METHODS: In a case-control design, 49 antipsychotic-treated, clinically stable, non-diabetic, schizophrenia spectrum male patients were compared with 93 healthy male controls by age (33.1, SD 7.4 vs. 32.9, SD 6.6 years), body mass index (26.2, SD 4.6 vs. 26.1, SD 3.9 kg/m(2)) and waist circumference (96.4, SD 13.0 vs. 96.7, SD 11.9 cm). Serum-prolactin was measured in the morning and 90 min after ingestion of a standardized liquid meal (2268 kJ). RESULTS: Fasting prolactin levels varied considerably, and mean fasting prolactin levels did not significantly differ between patients and controls (12.33, SD 11.58 vs. 10.06, SD 8.67 ng/ml, p = 0.623). In the controls, postprandial serum prolactin was significantly reduced (Δ -2.53, SD 9.75 ng/ml, p = 0.016). In antipsychotic-treated patients postprandial serum prolactin tended to increase (Δ 2.62, SD 10.96 ng/ml, p = 0.081). Analyses of subgroups based on the prolactinogenic liability of their antipsychotic treatment indicated 22 to 65% higher postprandial prolactin levels with high and intermediate prolactinogenic antipsychotics. DISCUSSION: A physiological postprandial suppression of serum prolactin appears absent in antipsychotic-treated males. Marked variability in fasting prolactin levels may reflect individual variations in the diurnal cycle. Uniform acquisition procedures accounting for diurnal variation and food intake may enhance reliability of prolactin levels in antipsychotic-treated male patients.
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All blood samples were collected in the morning before food intake (fasting >8 h) to control for diurnal variation of CTX and prolactin.
“Since CTX (8) and prolactin (22) are influenced by diurnal variations, all blood samples were collected in the morning before food intake (fasting >8 h).”
Individual antipsychotic compounds may affect prolactin levels and bone status differentially.
“To this end, individual antipsychotic compounds may affect prolactin levels (22, 31, 32), and bone status differentially, but the current data did not allow for separating effects of specific antipsychotics.”
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“Since CTX (8) and prolactin (22) are influenced by diurnal variations, all blood samples were collected in themorning before food intake (fasting >8 h).”
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“This was consistent with the results of Coelloa et al. [29], which demonstrated a postprandial prolactin suppression in healthy males.”
ResultReeves, G. M., & Sikich, L. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_37
- Authors
- Coello, K., Broberg, B. V., Bak, N., Madsen, A., Mortensen, H. B., Søgaard, B., Szecsi, P. B., Knop, F. K., Lublin, H., & Ebdrup, B. H.
- Affiliations
- Mental Health Services (DK)
- University of Copenhagen (DK)
- Lundbeck (Denmark) (DK)
- Corresponding author
- Ebdrup, Bjørn H.
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 60
- Pages
- 1-6
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W1829522620
- Cited by
- 7
- References
- 15
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Funders
- Lundbeckfonden (R155-2013-16337, R25-A2701)
- Region Hovedstaden (R25-A2701)
- H. Lundbeck A/S
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- antipsychotic drugs, hyperprolactinemia, schizophrenia spectrum, meal ingestion, diurnal variation, metabolic disorders, diabetes risk
- MeSH terms
- Adult, Humans, Hyperprolactinemia, Male, Middle Aged, Prolactin, Risk Factors, Schizophrenia, Antipsychotic Agents, Body Mass Index, Case-Control Studies, Postprandial Period, Waist Circumference, Young Adult
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