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Cited by 95Macrophage Migration Inhibitory FactorParasites and Host InteractionsHelminth infection and control

Orthologs of macrophage migration inhibitory factor from parasitic nematodes

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Vermeire, Jon J., Cho, Yoonsang, Lolis, Elias, Bucala, Richard, Cappello, Michael·2008·Trends in Parasitology
DOI 10.1016/j.pt.2008.04.007PMC PMC3615561
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Abstract

Chronic helminth infections are associated with modulation of host cellular immune responses, presumably to prolong parasite survival within the mammalian host. This phenomenon is attributed, at least in part, to the elaboration of parasite molecules, including orthologs of host cytokines and receptors, at the host-parasite interface. This review describes recent progress in the characterization of macrophage migration inhibitory factor (MIF) orthologs from parasitic nematodes. The roles of these molecules in parasite developmental biology and pathogenesis are discussed. Further knowledge of the species-specific activities and three-dimensional structures of human and parasitic nematode MIF molecules should make them ideal targets for drug- and/or vaccine-based strategies aimed at nematode disease control.

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Cited by

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Authors
Vermeire, J. J., Cho, Y., Lolis, E., Bucala, R., & Cappello, M.
Affiliations
Yale University (US)
Corresponding author
Vermeire, Jon J.
ORCID
Venue
Trends in Parasitology
Publisher
Elsevier BV
Published
2008-08
Volume
24
Issue
8
Pages
355-363
ISSN
1471-4922 (ISSN-L)
DOI
10.1016/j.pt.2008.04.007
PMC
PMC3615561
OpenAlex
W2012117769
Cited by
95
References
1
Citations by year
2026: 2 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 9
FWCI
0.71
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01ai065029-05)
  • National Institute of Allergy and Infectious Diseases (R01 AI-065029, AI51306, AI 065029, R01AI051306, AI058980, AI42310, R01AI042310, R01AI058980, R56AI042310)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
Keywords
macrophage migration inhibitory factor, parasitic nematodes, helminthiasis, cytokine receptors, therapeutic target, vaccine targets, host-parasite interface
MeSH terms
Animals, Gene Expression Regulation, Host-Parasite Interactions, Humans, Macrophage Migration-Inhibitory Factors, Macrophages, Nematoda, Nematode Infections

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