The many faces of macrophage activation

NITRIC OXIDE AND MACROPHAGE FUNCTION

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M-1/M-2 Macrophages and the Th1/Th2 Paradigm

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Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

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Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

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Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

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Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

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Other Functions, Other Genes

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Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

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Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

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Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts

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Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages

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Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

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A novel phenotype for an activated macrophage: the type 2 activated macrophage

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Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I

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Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production

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Alternative versus Classical Activation of Macrophages

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Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.

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Alternatively Activated Macrophages Differentially Express Fibronectin and Its Splice Variants and the Extracellular Matrix Protein βIG‐H3

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Reversing Lipopolysaccharide Toxicity by Ligating the Macrophage Fcγ Receptors

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Mycobacterium tuberculosis Inhibits IFN-γ Transcriptional Responses Without Inhibiting Activation of STAT1

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Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.

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Alternative Macrophage Activation-Associated CC-Chemokine-1, a Novel Structural Homologue of Macrophage Inflammatory Protein-1α with a Th2-Associated Expression Pattern

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Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fcγ Receptors

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Interferon‐lnduced Indoleamine 2,3‐Dioxygenase Activity in Human Mononuclear Phagocytes

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TGF-β in infections and infectious diseases

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Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro

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Interleukin-10 and its receptor.

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Interleukin-3 and its receptor

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Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport

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Activation of the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase by Macrophage-Stimulating Protein Results in the Induction of Arginase Activity in Murine Peritoneal Macrophages

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Infection and Nitric Oxide

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Association of lung carcinoma and tuberculosis.

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Alterations of Surface Properties by Macrophage Activation: Expression of Receptors for Fc and Mannose-Terminal Glycoproteins and Differentiation Antigens

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Mechanisms and modulation of macrophage activation.

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Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis

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Treatment of murine macrophages with interferon-γ inhibits their ability to bind leishmania promastigotes

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The Relationship of Inflammation and Initiation of Autoimmune Disease: Role of TNF Super Family Members

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Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works

NF-κB signaling in inflammation

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The chemokine system in diverse forms of macrophage activation and polarization

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Monocyte and macrophage heterogeneity

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Foreign body reaction to biomaterials

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Macrophage activation and polarization

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Alternative Activation of Macrophages: An Immunologic Functional Perspective

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Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

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Transition from inflammation to proliferation: a critical step during wound healing

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Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

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Epidemiology of and Diagnostic Strategies for Toxoplasmosis

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Inflammation and wound healing: the role of the macrophage

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The Isolation and Characterization of Murine Macrophages

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Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy

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Repertoire of microglial and macrophage responses after spinal cord injury

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Immune responses to implants – a review of the implications for the design of immunomodulatory biomaterials

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THP-1 cell line: An in vitro cell model for immune modulation approach

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Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

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Macrophage Polarization in Bacterial Infections

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The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.

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Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation

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Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

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Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

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Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine

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Protective immune mechanisms in helminth infection

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Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component

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Role of tumor-associated macrophages in tumor progression and invasion

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Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

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CD4 + CD25 + Foxp3 + regulatory T cells induce alternative activation of human monocytes/macrophages

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Immune response to biologic scaffold materials

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Biomaterial based modulation of macrophage polarization: a review and suggested design principles

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Macrophages in skin injury and repair.

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Circular RNA and its mechanisms in disease: From the bench to the clinic

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Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

Kim, J., & Hematti, P. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.09.004 · Cited by 785 · see citing works

Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials

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Functional plasticity of macrophages: reversible adaptation to changing microenvironments

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Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling

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Macrophage diversity in renal injury and repair

Ricardo, S. D., van Goor, H., & Eddy, A. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36150 · Cited by 726 · see citing works

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

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Mechanisms of insulin resistance in obesity

Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699 · see citing works

Medical biofilms

Bryers, J. D. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21838 · Cited by 705 · see citing works

Glial reactions in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701 · see citing works

Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials

Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701 · see citing works

A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)

Biswas, S. K. (2005) · Blood · doi:10.1182/blood-2005-01-0428 · Cited by 693 · see citing works

Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas

Komohara, Y., Ohnishi, K., Kuratsu, J., & Takeya, M. (2008) · The Journal of Pathology · doi:10.1002/path.2370 · Cited by 738 · see citing works

Macrophage phenotypes in atherosclerosis

Colin, S., Chinetti‐Gbaguidi, G., & Staels, B. (2014) · Immunological Reviews · doi:10.1111/imr.12218 · Cited by 657 · see citing works

Macrophage phenotypes during tissue repair

Novak, M. L., & Koh, T. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012512 · Cited by 658 · see citing works

Inflammation and its role in age-related macular degeneration

Kauppinen, A., Paterno, J. J., Błasiak, J., Salminen, A., & Kaarniranta, K. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2147-8 · Cited by 660 · see citing works

Macrophage subsets in atherosclerosis

Chinetti, G., Colin, S., & Staels, B. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.173 · Cited by 640 · see citing works

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Rayahin, J., Buhrman, J. S., Zhang, Y., Koh, T. J., & Gemeinhart, R. A. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00181 · Cited by 615 · see citing works

Macrophages in bone fracture healing: Their essential role in endochondral ossification

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Macrophage activation by endogenous danger signals

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Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

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NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

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Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

The mannose receptor

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Tumour immunity: effector response to tumour and role of the microenvironment

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Inflammation and the Degenerative Diseases of Aging

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Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

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Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation

Fleetwood, A. J., Lawrence, T., Hamilton, J. A., & Cook, A. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5245 · Cited by 607 · see citing works

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

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Wallerian degeneration: the innate-immune response to traumatic nerve injury

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PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

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