The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Artemisinin Action and Resistance in Plasmodium falciparum
Open accessAbstract
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in recent years to a substantial reduction in deaths resulting from Plasmodium falciparum malaria. Resistance to artemisinins, however, has emerged in Southeast Asia. Clinically, resistance is defined as a slower rate of parasite clearance in patients treated with an artemisinin derivative or an ACT. These slow clearance rates associate with enhanced survival rates of ring-stage parasites briefly exposed in vitro to dihydroartemisinin. We describe recent progress made in defining the molecular basis of artemisinin resistance, which has identified a primary role for the P. falciparum K13 protein. Using K13 mutations as molecular markers, epidemiological studies are now tracking the emergence and spread of artemisinin resistance. Mechanistic studies suggest potential ways to overcome resistance.
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Cites
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Cited by
White, N. J. (2017) · Malaria Journal · doi:10.1186/s12936-017-1731-1 · Cited by 230
Nayak, S., Peto, T. J., Kucharski, M., Tripura, R., Callery, J. J., Quang Huy, D. T., Gendrot, M., Lek, D., Nghia, H. D. T., van der Pluijm, R. W., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54915-6 · Cited by 15
Malaria – Current Treatment Options
Virginia, D. M., Shegokar, R., & Pathak, Y. (2023) · Malarial Drug Delivery Systems · doi:10.1007/978-3-031-15848-3_4 · Cited by 1
Metadata
- Authors
- Tilley, L., Straimer, J., Gnädig, N. F., Ralph, S. A., & Fidock, D. A.
- Venue
- Trends in Parasitology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 32
- Issue
- 9
- Pages
- 682-696
- ISSN
- 1471-4922 (ISSN-L)
- OpenAlex
- W2415187468
- Cited by
- 359
- References
- 120
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Tilley, L., Straimer, J., Gnädig, N. F., Ralph, S. A., & Fidock, D. A. (2016). Artemisinin Action and Resistance in Plasmodium falciparum. Trends in Parasitology. https://doi.org/10.1016/j.pt.2016.05.010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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