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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

Open access
Ariey, Frédéric, Witkowski, Benoit, Amaratunga, Chanaki, Beghain, Johann, Langlois, Anne-Claire, Khim, Nimol, Kim, Saorin, Duru, Valentine, Bouchier, Christiane, Ma, Laurence, Lim, Pharath, Leang, Rithea, Duong, Socheat, Sreng, Sokunthea, Suon, Seila, Chuor, Char Meng, Bout, Denis Mey, Ménard, Sandie, Rogers, William O., Genton, Blaise, Fandeur, Thierry, Miotto, Olivo, Ringwald, Pascal, Le Bras, Jacques, Berry, Antoine, Barale, Jean-Christophe, Fairhurst, Rick M., Benoit-Vical, Françoise, Mercereau-Puijalon, Odile, Ménard, Didier·2014·Nature
DOI 10.1038/nature12876
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Abstract

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain (‘K13-propeller’) with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread.

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Metadata

Authors
Ariey, F., Witkowski, B., Amaratunga, C., Beghain, J., Langlois, A.-C., Khim, N., Kim, S., Duru, V., Bouchier, C., Ma, L., Lim, P., Leang, R., Duong, S., Sreng, S., Suon, S., Chuor, C. M., Bout, D. M., Ménard, S., Rogers, W. O., Genton, B., Fandeur, T., Miotto, O., Ringwald, P., Le Bras, J., Berry, A., Barale, J.-C., Fairhurst, R. M., Benoit-Vical, F., Mercereau-Puijalon, O., & Ménard, D.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2013-12-18
Volume
505
Issue
7481
Pages
50-55
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature12876
OpenAlex
W2124634096
Cited by
2,090
References
5
FWCI
157.25
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. https://app.cochat.ai/papers/10.1038/nature12876
The paper
Ariey, F., Witkowski, B., Amaratunga, C., Beghain, J., Langlois, A.-C., Khim, N., Kim, S., Duru, V., Bouchier, C., Ma, L., Lim, P., Leang, R., Duong, S., Sreng, S., Suon, S., Chuor, C. M., Bout, D. M., Ménard, S., Rogers, W. O., . . . Ménard, D. (2014). A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. https://doi.org/10.1038/nature12876

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.