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Cited by 71Management of metastatic bone diseaseSpinal Fractures and Fixation TechniquesBone health and treatments

The effect of resistance training during radiotherapy on spinal bone metastases in cancer patients—a randomized trial

Rief, Harald, Petersen, Lina C., Omlor, Georg, Akbar, Michael, Bruckner, Thomas, Rieken, Stefan, Haefner, Matthias F., Schlampp, Ingmar +3 more·2014·Radiotherapy and Oncology
DOI 10.1016/j.radonc.2014.06.008
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Abstract

Purpose To compare the effects of resistance training versus passive physical therapy on bone density in the metastatic bone during radiation therapy (RT) as combined treatment in patients with spinal bone metastases. Secondly, to quantify pathological fractures after combined treatment.Material and methods In this randomized trial, 60 patients were allocated from September 2011 until March 2013 into one of the two groups: resistance training (group A) or passive physical therapy (group B) with thirty patients in each group during RT. Bone density in metastatic and non-metastatic vertebral bone was assessed at baseline, 3 and 6 months after RT.Results Bone density in all metastases increased significantly by 28.3% (IQR 11.4-139.0) and 80.3% (IQR 32.6-250.6) after 3 and 6 months in group A (both p < 0.01). The bone density in group A was significantly increased compared to control group after 3 and 6months (both p < 0.01, median 59.7; IQR 21.1-98.3 and median 62.9; IQR -9.7 to 161.7). The bone density data in group B showed no significant increase over the course of time (p = 0.289, median 5.5, IQR 0.0-62.2 and p = 0.057, median 52.1, IQR 0.0-162.7). 23.3% of the patients in group A and 30.0% of the patients in group B had pathological fractures, no fracture was assigned to intervention, and no difference between groups after 3 and 6 months was observed (p = 0.592 and p = 0.604).Conclusions Our trial demonstrated that resistance training concomitant to RT can improve bone density in spinal bone metastases. This combined treatment is effective, practicable, and without side effects for patients. Importantly, the pathological fracture rate in the intervention group was not increased. The results offer a rationale for future large controlled investigations to confirm these findings.Trial registration Clinical trial identifier NCT01409720.

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  • Consistent observational evidence shows that physical activity after cancer diagnosis reduces the risk of cancer-specific and all-cause mortality for individuals with early stage breast, colorectal, and prostate cancer.

    “There is consistent observational evidence that engaging in physical activity following a cancer diagnosis reduces the risk of cancer-specific and all-cause mortality for individuals diagnosed with early stage breast, colorectal and prostate cancer(104).”

    From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [104]

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Authors
Rief, H., Petersen, L. C., Omlor, G., Akbar, M., Bruckner, T., Rieken, S., Haefner, M. F., Schlampp, I., Förster, R., Debus, J., & Welzel, T.
Affiliations
University Hospital Heidelberg (DE)
Corresponding author
  • Rief, Harald
  • Petersen, Lina C.
  • Omlor, Georg
  • Bruckner, Thomas
  • Rieken, Stefan
  • Haefner, Matthias F.
  • Schlampp, Ingmar
  • Debus, Jürgen
  • Welzel, Thomas
ORCID
Venue
Radiotherapy and Oncology
Publisher
Elsevier BV
Published
2014-07
Volume
112
Issue
1
Pages
133-139
ISSN
0167-8140 (ISSN-L)
DOI
10.1016/j.radonc.2014.06.008
OpenAlex
W2091726011
Cited by
71
References
30
Citations by year
2026: 1 · 2025: 11 · 2024: 4 · 2023: 3 · 2022: 12 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 1
FWCI
3.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Radiotherapy and Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Management of metastatic bone disease
  • Health Sciences › Medicine › Surgery › Spinal Fractures and Fixation Techniques
  • Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords
resistance training, spinal bone metastases, radiotherapy, bone mineral density, pathological fracture, cancer patients
MeSH terms
Aged, Breast Neoplasms, Carcinoma, Combined Modality Therapy, Female, Humans, Kidney Neoplasms, Lung Neoplasms, Male, Melanoma, Middle Aged, Neoplasms, Palliative Care, Prostatic Neoplasms, Skin Neoplasms, Spinal Neoplasms, Bone Density, Physical Therapy Modalities, Resistance Training

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