A systematic review of health economic evaluation in adjuvant breast radiotherapy: Quality counted by numbers

Monten, Chris; Veldeman, Liv; Verhaeghe, Nick; Lievens, Yolande

doi:10.1016/j.radonc.2017.08.034

Cited by 22Health Systems, Economic Evaluations, Quality of LifeMeta-analysis and systematic reviewsBreast Cancer Treatment Studies

A systematic review of health economic evaluation in adjuvant breast radiotherapy: Quality counted by numbers

Monten, Chris, Veldeman, Liv, Verhaeghe, Nick, Lievens, Yolande·2017·Radiotherapy and Oncology

DOI 10.1016/j.radonc.2017.08.034

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Abstract

Background Evolving practice in adjuvant breast radiotherapy inevitably impacts healthcare budgets. This is reflected in a rise of health economic evaluations (HEE) in this domain. The available HEE literature was analysed qualitatively and quantitatively, using available instruments.Methods HEEs published between 1/1/2000 and 31/10/2016 were retrieved through a systematic search in Medline, Cochrane and Embase. A quality-assessment using CHEERS (Consolidated Health Economic Evaluation Reporting Standards) was translated into a quantitative score and compared with Tufts Medical Centre CEA registry and Quality of Health Economic Studies (QHES) results.Results Twenty cost-effectiveness analyses (CEA) and thirteen cost comparisons (CC) were analysed. In qualitative evaluation, valuation or justification of data sources, population heterogeneity and discussion on generalizability, in addition to declaration on funding, were often absent or incomplete. After quantification, the average CHEERS-scores were 74% (CI 66.9-81.1%) and 75.6% (CI 70.7-80.5%) for CEAs and CCs respectively. CEA-scores did not differ significantly from Tufts and QHES-scores.Conclusion Quantitative CHEERS evaluation is feasible and yields comparable results to validated instruments. HEE in adjuvant breast radiotherapy is of acceptable quality, however, further efforts are needed to improve comprehensive reporting of all data, indispensable for assessing relevance, reliability and generalizability of results.

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From Cost and cost-effectiveness of mHealth interventions for the prevention and control of type 2 diabetes mellitus: A systematic review (2020) · cites this paper as [59]

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Methods for the Economic Evaluation of Health Care Programmes
Drummond, M. E., Sculpher, M. J., Torrance, G. W., O’Brien, B. J., & Stoddart, G. L. (2005) · doi:10.1093/oso/9780198529446.001.0001 · Cited by 13,648 · see citing works
Long-Term Results of Hypofractionated Radiation Therapy for Breast Cancer
Whelan, T. J., Pignol, J., Levine, M. N., Julian, J. A., MacKenzie, R., Parpia, S., Shelley, W. E., Grimard, L., Bowen, J., Lukka, H. R., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906260 · Cited by 1,881 · see citing works
Guidelines for authors and peer reviewers of economic submissions to the BMJ
Drummond, M. F., & Jefferson, T. O. (1996) · BMJ · doi:10.1136/bmj.313.7052.275 · Cited by 1,827 · see citing works
Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement
Husereau, D., Drummond, M., Petrou, S., Carswell, C., Moher, D., Greenberg, D., Augustovski, F., Briggs, A. H., Mauskopf, J., Loder, E., et al. (2013) · BMJ · doi:10.1136/bmj.f1049 · Cited by 1,776 · see citing works
The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials
Haviland, J., Owen, J. R., Dewar, J. A., Agrawal, R. K., Barrett, J., Barrett-Lee, P. J., Dobbs, H. J., Hopwood, P., Lawton, P. A., Magee, B., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70386-3 · Cited by 1,485 · see citing works
Expanding global access to radiotherapy
Atun, R., Jaffray, D. A., Barton, M. B., Bray, F., Baumann, M., Vikram, B., Hanna, T. P., Knaul, F. M., Lievens, Y., Lui, T. Y. M., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00222-3 · Cited by 1,112 · see citing works
Self-citation
Criteria list for assessment of methodological quality of economic evaluations: Consensus on Health Economic Criteria
Evers, S., Goossens, M. E. J. B., de Vet, H. C. W., van Tulder, M. W., & Ament, A. J. H. A. (2005) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462305050324 · Cited by 860 · see citing works
Model Transparency and Validation
Eddy, D. M., Hollingworth, W., Jaime, J., Tsevat, J., McDonald, K. M., & Wong, J. B. (2012) · Medical Decision Making · doi:10.1177/0272989x12454579 · Cited by 803 · see citing works
Delivering affordable cancer care in high-income countries
Sullivan, R., Peppercorn, J., Sikora, K., Zalcberg, J., Meropol, N. J., Amir, E., Khayat, D., Boyle, P., Autier, P., Tannock, I. F., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70141-3 · Cited by 718 · see citing works
Model Transparency and Validation: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-7
Eddy, D. M., Hollingworth, W., Caro, J. J., Tsevat, J., McDonald, K. M., & Wong, J. B. (2012) · Value in Health · doi:10.1016/j.jval.2012.04.012 · Cited by 466 · see citing works
Examining the Value and Quality of Health Economic Analyses: Implications of Utilizing the QHES
Ofman, J. J., Sullivan, S. D., Neumann, P. J., Chiou, C.-F., Henning, J. M., Wade, S. W., & Hay, J. W. (2003) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2003.9.1.53 · Cited by 366 · see citing works
Development and Validation of a Grading System for the Quality of Cost-Effectiveness Studies
Chiou, C., Hay, J. W., Wallace, J. F., Bloom, B. S., Neumann, P. J., Sullivan, S. D., Yu, H.-T., Keeler, E. B., Henning, J. M., & Ofman, J. J. (2003) · Medical Care · doi:10.1097/00005650-200301000-00007 · Cited by 308 · see citing works
Uptake and Costs of Hypofractionated vs Conventional Whole Breast Irradiation After Breast Conserving Surgery in the United States, 2008–2013
Bekelman, J. E., Sylwestrzak, G., Barron, J. O., Liu, J., Epstein, A. J., Freedman, G. M., Malin, J. L., & Emanuel, E. (2014) · JAMA · doi:10.1001/jama.2014.16616 · Cited by 213 · see citing works
A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions
Plumpton, C., Roberts, D. J., Pirmohamed, M., & Hughes, D. A. (2016) · PharmacoEconomics · doi:10.1007/s40273-016-0397-9 · Cited by 149 · see citing works
The impact of cancer incidence and stage on optimal utilization of radiotherapy: Methodology of a population based analysis by the ESTRO-HERO project
Borràs, J. M., Barton, M. B., Grau, C., Corral, J., Verhoeven, R. H. A., Lemmens, V. E. P. P., Eycken, L. J. V., Henau, K., Primic‐Žakelj, M., Strojan, P., et al. (2015) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2015.04.021 · Cited by 143 · see citing works
Self-citation
Cost-effectiveness of Store-and-Forward Teledermatology: A Systematic Review
Snoswell, C., Finnane, A., Janda, M., Soyer, H. P., & Whitty, J. A. (2016) · JAMA Dermatology · doi:10.1001/jamadermatol.2016.0525 · Cited by 140 · see citing works
Adoption of Intensity-Modulated Radiation Therapy for Breast Cancer in the United States
Smith, B. D., Pan, I.-W. E., Shih, Y. T., Smith, G. L., Harris, J. R., Punglia, R. S., Pierce, L. J., Jagsi, R., Hayman, J. A., Giordano, S. H., et al. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr100 · Cited by 136 · see citing works
Cost-effectiveness of strategies to improve the utilization and provision of maternal and newborn health care in low-income and lower-middle-income countries: a systematic review
Mangham‐Jefferies, L., Pitt, C., Cousens, S. N., MILLS, A. J., & Schellenberg, J. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-14-243 · Cited by 133 · see citing works
A cost comparison analysis of partial versus whole-breast irradiation after breast-conserving surgery for early-stage breast cancer
Suh, W. W., Pierce, L. J., Vicini, F. A., & Hayman, J. A. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.10.039 · Cited by 119 · see citing works
A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial
Prescott, R. J., Kunkler, I. H., Williams, L., King, C., Jack, W. J. L., Pol, M. M. V. D., Goh, T., Lindley, R. I., & Cairns, J. (2007) · Health Technology Assessment · doi:10.3310/hta11310 · Cited by 112 · see citing works
Accelerated Partial Breast Irradiation With IMRT: New Technical Approach and Interim Analysis of Acute Toxicity in a Phase III Randomized Clinical Trial
Livi, L., Buonamici, F. B., Simontacchi, G., Scotti, V., Fambrini, M., Compagnucci, A., Paiar, F., Scoccianti, S., Pallotta, S., Detti, B., et al. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.04.070 · Cited by 112 · see citing works
Costs of Treatment for Elderly Women With Early-Stage Breast Cancer in Fee-for-Service Settings
Warren, J. L. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.1.307 · Cited by 110 · see citing works
2–40 A Cost Comparison Analysis of Partial Versus Whole-Breast Irradiation After Breast-Conserving Surgery for Early-Stage Breast Cancer
Perez, C. A. (2006) · Breast Diseases A Year Book Quarterly · doi:10.1016/s1043-321x(06)80456-x · Cited by 107 · see citing works
A Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis
Hiligsmann, M., Evers, S., Sedrine, W. B., Kanis, J. А., Ramaekers, B. L. T., Reginster, J., Silverman, S. L., Wyers, C. E., & Boonen, A. E. R. C. H. (2014) · PharmacoEconomics · doi:10.1007/s40273-014-0231-1 · Cited by 101 · see citing works
Cost and Complications of Local Therapies for Early-Stage Breast Cancer
Smith, B. D., Jiang, J., Shih, Y. T., Giordano, S. H., Huo, J. S., Jagsi, R., Momoh, A. O., Caudle, A. S., Hunt, K. K., Shaitelman, S. F., et al. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw178 · Cited by 101 · see citing works
Economic evaluation of proton radiation therapy in the treatment of breast cancer
Lundkvist, J., Ekman, M., Ericsson, S. R., Isacsson, U., Jönsson, B., & Glimelius, B. L. G. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.03.006 · Cited by 94 · see citing works
Hypofractionated breast radiotherapy: Financial and economic consequences
Lievens, Y. N. (2010) · The Breast · doi:10.1016/j.breast.2010.03.003 · Cited by 91 · see citing works
Self-citation
Comparison of three instruments assessing the quality of economic evaluations: A practical exercise on economic evaluations of the surgical treatment of obesity
Gerkens, S., Crott, R., Cleemput, I., Thissen, J., Closon, M.-C. M.-C. C., Horsmans, Y., & Beguin, C. (2008) · International Journal of Technology Assessment in Health Care · doi:10.1017/s0266462308080422 · Cited by 80 · see citing works
Systematic Review of Modelling Approaches for the Cost Effectiveness of Hepatitis C Treatment with Direct-Acting Antivirals
Chhatwal, J., He, T., & Lopez-Olivo, M. A. (2016) · PharmacoEconomics · doi:10.1007/s40273-015-0373-9 · Cited by 79 · see citing works
Cost-Effectiveness Analysis of Intraoperative Radiation Therapy for Early-Stage Breast Cancer
Alvarado, M. D., Mohan, A. J., Esserman, L. J., Park, C. C., Harrison, B. L., Howe, R. J., Thorsen, C. M., & Ozanne, E. M. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-2997-3 · Cited by 73 · see citing works
Considerations for Observational Research Using Large Data Sets in Radiation Oncology
Jagsi, R., Bekelman, J. E., Chen, A. B., Chen, R. C., Hoffman, K. E., Shih, Y. T., Smith, B. D., & Yu, J. B. (2014) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2014.05.013 · Cited by 72 · see citing works
Costs of Treatment for Elderly Women With Early-Stage Breast Cancer in Fee-for-Service Settings
Warren, J. L., Brown, M. L., Fay, M. P., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.1.307 · Cited by 71 · see citing works
Partial-Breast Irradiation Versus Whole-Breast Irradiation for Early-Stage Breast Cancer: A Cost-Effectiveness Analysis
Sher, D. J., Wittenberg, E., Suh, W. W., Taghian, A. G., & Punglia, R. S. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.08.015 · Cited by 68 · see citing works
Accelerated partial breast irradiation trials: Diversity in rationale and design
Mannino, M., & Yarnold, J. R. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2008.12.011 · Cited by 68 · see citing works
Cost Comparison of Radiation Treatment Options After Lumpectomy for Breast Cancer
Greenup, R. A., Camp, M. S., Taghian, A. G., Buckley, J. M., Coopey, S. B., Gadd, M. A., Hughes, K. S., Specht, M. C., & Smith, B. L. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2546-5 · Cited by 66 · see citing works
A systematic review of economic evaluations of population-based sodium reduction interventions
Hope, S. F., Webster, J. L., Trieu, K., Pillay, A. A., Ieremia, M., Bell, C., Snowdon, W., Neal, B. C., & Moodie, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173600 · Cited by 65 · see citing works
An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial)
Vaidya, J. S., Wenz, F. K., Bulsara, M. K., Tobias, J. S., Joseph, D. J., Saunders, C. M., Brew‐Graves, C., Potyka, I., Stephen Morris, A., Vaidya, H. J., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20730 · Cited by 64 · see citing works
Economic Evaluation of Interventions for Prevention of Hospital Acquired Infections: A Systematic Review
Arefian, H., Vogel, M., Kwetkat, A., & Hartmann, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146381 · Cited by 63 · see citing works
Evaluating Radiotherapy Options in Breast Cancer: Does Intraoperative Radiotherapy Represent the Most Cost-Efficacious Option?
Shah, C., Badiyan, S. N., Khwaja, S. S., Shah, H., Chitalia, A., Nanavati, A., Kundu, N., Vaka, V., Lanni, T. B., & Vicini, F. A. (2013) · Clinical Breast Cancer · doi:10.1016/j.clbc.2013.10.005 · Cited by 58 · see citing works
Establishing Cost-Effective Allocation of Proton Therapy for Breast Irradiation
Vega, R. B. M., Ishaq, O. F., Raldow, A. C., Perez, C. A., Jimenez, R., Scherrer‐Crosbie, M., Bussière, M. R., Taghian, A. G., Sher, D. J., & MacDonald, S. M. (2016) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2016.02.031 · Cited by 57 · see citing works
Cost-efficacy of acceleration partial-breast irradiation compared with whole-breast irradiation
Shah, C., Lanni, T. B., Saini, H., Nanavati, A., Wilkinson, J. B., Badiyan, S. N., & Vicini, F. A. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2412-6 · Cited by 55 · see citing works
Decision-Analytic Model and Cost-Effectiveness Evaluation of Postmastectomy Radiation Therapy in High-Risk Premenopausal Breast Cancer Patients
Lee, J. H., Glick, H. A., Hayman, J. A., & Solin, L. J. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.07.008 · Cited by 55 · see citing works
Stereotactic Body Radiotherapy for Lung Cancer: How Much Does it Really Cost?
Lievens, Y. N., Obyn, C., Mertens, A.-S., Halewyck, D. V., & Hulstaert, F. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000421 · Cited by 50 · see citing works
Self-citation
A systematic review of economic evaluations of treatments for patients with epilepsy
Wijnen, B. F. M., van Mastrigt, G. A. P. G., Evers, S., Gershuni, O., Lambrechts, D. A. J. E., Majoie, M., Postulart, D., Aldenkamp, A. P., & de Kinderen, R. J. A. (2017) · Epilepsia · doi:10.1111/epi.13655 · Cited by 49 · see citing works
Cost Effectiveness of Dipeptidyl Peptidase-4 Inhibitors for Type 2 Diabetes
Geng, J., Yu, H., Mao, Y., Zhang, P., & Chen, Y. (2015) · PharmacoEconomics · doi:10.1007/s40273-015-0266-y · Cited by 46 · see citing works
Cost-Effectiveness of Adding an Electron-Beam Boost to Tangential Radiation Therapy in Patients With Negative Margins After Conservative Surgery for Early-Stage Breast Cancer
Hayman, J. A., Hillner, B. E., Harris, J. R., Pierce, L. J., & Weeks, J. C. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.2.287 · Cited by 41 · see citing works
Cost-effectiveness of radiation therapy following conservative surgery for ductal carcinoma in situ of the breast
Suh, W. W., Hillner, B. E., Pierce, L. J., & Hayman, J. A. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.07.713 · Cited by 39 · see citing works
Examining the Cost-Effectiveness of Radiation Therapy Among Older Women With Favorable-Risk Breast Cancer
Sen, S., Wang, S., Soulos, P. R., Frick, K. D., Long, J. B., Roberts, K. B., Yu, J. B., Evans, S. B., Chagpar, A. B., & Gross, C. P. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju008 · Cited by 39 · see citing works
A Cost Comparison Analysis of Adjuvant Radiation Therapy Techniques after Breast-Conserving Surgery
Lanni, T. B., Keisch, M. E., Shah, C., Wobb, J., Kestin, L. L., & Vicini, F. A. (2013) · The Breast Journal · doi:10.1111/tbj.12075 · Cited by 39 · see citing works
Economic Evaluation of Family Planning Interventions in Low and Middle Income Countries; A Systematic Review
Zakiyah, N., van Asselt, A. D. I., Roijmans, F., & Postma, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168447 · Cited by 37 · see citing works
Time-Driven Activity-Based Costing: A Comparative Cost Analysis of Whole-Breast Radiotherapy Versus Balloon-Based Brachytherapy in the Management of Early-Stage Breast Cancer
Schutzer, M. E., Arthur, D. W., & Anscher, M. S. (2016) · Journal of Oncology Practice · doi:10.1200/jop.2015.008441 · Cited by 36 · see citing works
Systematic review of the economic evaluations of novel therapeutic agents in multiple myeloma: what is the reporting quality?
Aguiar, P. M., Lima, T. D. M., & Storpirtis, S. (2016) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12384 · Cited by 29 · see citing works
A cost-outcome analysis of adjuvant postmastectomy locoregional radiotherapy in premenopausal node-positive breast cancer patients
Dunscombe, P., Samant, R. S., & Roberts, G. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00672-6 · Cited by 28 · see citing works
Evaluation of Health Economics in Radiation Oncology: A Systematic Review
Nguyen, T. K., Goodman, C. D., Boldt, G., Warner, A., Palma, D. A., Rodrigues, G., Lock, M. I., Mishra, M. V., Zaric, G. S., & Louie, A. V. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.12.359 · Cited by 27 · see citing works
The INTRABEAM® Photon Radiotherapy System for the adjuvant treatment of early breast cancer: a systematic review and economic evaluation
Picot, J., Copley, V. R., Colquitt, J. L., Kalita, N., Hartwell, D., & Bryant, J. (2015) · Health Technology Assessment · doi:10.3310/hta19690 · Cited by 25 · see citing works
Economic case for intraoperative interventions to prevent surgical-site infection
Gillespie, B. M., Chaboyer, W. P., Erichsen-Andersson, A., Hettiarachchi, R. M., & Kularatna, S. (2017) · British journal of surgery · doi:10.1002/bjs.10428 · Cited by 24 · see citing works
Cost-effectiveness analysis of vaccinations and decision makings on vaccination programmes in Hong Kong: A systematic review
Wong, C. K. H., Liao, Q., Guo, V. Y., Xin, Y., & Lam, C. L. K. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.04.050 · Cited by 23 · see citing works
Use of hypofractionated post‐mastectomy radiotherapy reduces health costs by over $2000 per patient: An A ustralian perspective
Mortimer, J. W., McLachlan, C. S., Hansen, C. J., Assareh, H., Last, A. J., McKay, M. J., & Shakespeare, T. P. (2015) · Journal of Medical Imaging and Radiation Oncology · doi:10.1111/1754-9485.12405 · Cited by 21 · see citing works
Economic Evaluations of Thrombophilia Screening Prior to Prescribing Combined Oral Contraceptives: A Systematic and Critical Review
Vernon, E., Hiedemann, B. G., & Bowie, B. H. (2017) · Applied Health Economics and Health Policy · doi:10.1007/s40258-017-0318-x · Cited by 19 · see citing works
What is the Quality of Economic Evaluations of Non-Drug Therapies? A Systematic Review and Critical Appraisal of Economic Evaluations of Radiotherapy for Cancer
Barbieri, M., Weatherly, H. L. A., Ara, R., Basarir, H., Sculpher, M. J., Adams, R., Ahmed, H. U., Coles, C. E., Urbano, T. G., Nutting, C. M., et al. (2014) · Applied Health Economics and Health Policy · doi:10.1007/s40258-014-0115-8 · Cited by 17 · see citing works
[Health economic evaluation reporting guideline and application status].
Xiao, J., Sun, J., Wang, Q. Q., Qi, X., & Yao, H. Y. (2017) · PubMed · doi:10.3760/cma.j.issn.0253-9624.2017.03.016 · Cited by 17 · see citing works
Economic evaluation of radiotherapy for early breast cancer after breast-conserving surgery in a health resource-limited setting
Bai, Y., Ye, M., Cao, H., Ma, X., Xu, Y., & Wu, B. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2268-1 · Cited by 16 · see citing works
Hypofractionated Radiation Therapy for Early Stage Breast Cancer: Outcomes, Toxicities, and Cost Analysis
Min, C., Connolly, E. P., Chen, T., Jozsef, G., & Formenti, S. C. (2014) · The Breast Journal · doi:10.1111/tbj.12254 · Cited by 14 · see citing works
Cost effectiveness of new breast cancer radiotherapy technologies in diverse populations
Gold, H. T., & Hayes, M. K. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2242-y · Cited by 14 · see citing works
Quality of pharmacoeconomic research in China
Ma, H., Jian, W., Xu, T., He, Y., Rizzo, J. A., & Fang, H. (2016) · Medicine · doi:10.1097/md.0000000000005114 · Cited by 12 · see citing works
Economic consequence of local control with radiotherapy: Cost analysis of internal mammary and medial supraclavicular lymph node radiotherapy in breast cancer
Lievens, Y. N., Kesteloot, K., & den Bogaert, W. V. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.03.064 · Cited by 10 · see citing works
Self-citation
Cost-Effectiveness of 3-Dimensional Conformal Radiotherapy and Applicator-based Brachytherapy in the Delivery of Accelerated Partial Breast Irradiation
Shah, C., Lanni, T. B., Wilkinson, J. B., Jawad, M. S., Wobb, J., Berry, S. K., Wallace, M. F., Chen, P., & Grills, I. S. (2012) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e318271b16d · Cited by 10 · see citing works
Subgroup Economic Evaluation of Radiotherapy for Breast Cancer After Mastectomy
Wan, X., Peng, L., Ma, J., Chen, G., & Li, Y. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.09.007 · Cited by 8 · see citing works
Cross-National Comparison of Medical Costs Shared by Payers and Patients: A Study of Postmenopausal Women with Early-Stage Breast Cancer Based on Assumption Case Scenarios and Reimbursement Fees
Hamada, S., Hinotsu, S., Ishiguro, H., Toi, M., & Kawakami, K. (2013) · Breast Care · doi:10.1159/000354249 · Cited by 8 · see citing works
Évolution des pratiques médicales d’hypofractionnement en radiothérapie pour cancer du sein et impact économique
Dupin, C. L., Vilotte, F., Lagarde, P., Petit, A., & Breton-Callu, C. (2016) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2016.04.005 · Cited by 6 · see citing works
Cost-effectiveness assessment of lumpectomy cavity boost in elderly women with early stage estrogen receptor positive breast cancer receiving adjuvant radiotherapy
Lester-Coll, N. H., Rutter, C. E., & Evans, S. B. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.01.026 · Cited by 4 · see citing works

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Authors: Monten, C., Veldeman, L., Verhaeghe, N., & Lievens, Y.
Affiliations: Ghent University Hospital (BE)
Ghent University (BE)
Corresponding author: Monten, Chris
ORCID: Monten, Chris
Veldeman, Liv
Verhaeghe, Nick
Lievens, Yolande
Venue: Radiotherapy and Oncology
Publisher: Elsevier BV
Published: 2017-11
Volume: 125
Issue: 2
Pages: 186-192
ISSN: 0167-8140 (ISSN-L)
DOI: 10.1016/j.radonc.2017.08.034
OpenAlex: W2755035165
Cited by: 22
References: 71
Citations by year: 2026: 2 · 2024: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2017: 1
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Radiotherapy and Oncology (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics: Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords: adjuvant breast radiotherapy, health economic evaluation, CHEERS, reporting quality, cost-effectiveness analysis, cost comparison, generalizability, funding disclosure
MeSH terms: Breast Neoplasms, Cost-Benefit Analysis, Female, Humans, Health Care Costs, Radiotherapy, Adjuvant

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A systematic review of health economic evaluation in adjuvant breast radiotherapy: Quality counted by numbers

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