The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Clinical translation of FLASH radiotherapy: Why and how?
Abstract
Over the past decades, technological advances have transformed radiation therapy (RT) into a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation-resistant tumors is still restricted by the dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool to enhance the differential effect between tumors and normal tissues. Indeed, preclinical studies on various animal models and a veterinarian clinical trial have recently shown that compared to conventional dose-rate RT, FLASH-RT could control tumors while minimizing normal tissue toxicity. In the present review, we summarize the main data supporting the clinical translation of FLASH-RT and explore its feasibility, the key irradiation parameters and the potential technologies needed for a successful clinical translation.
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Self-citationHyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis
Bourhis, J., Overgaard, J., Audry, H., Ang, K. K., Saunders, M., Bernier, J., Horiot, J.-C., Le Maître, A., Pajak, T. F., Poulsen, M. G., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69121-6 · Cited by 1,085
Self-citationMontay-Gruel, P., Petersson, K., Jaccard, M., Boivin, G., Germond, J.-F., Petit, B., Doenlen, R., Favaudon, V., Bochud, F., Bailat, C., et al. (2017) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2017.05.003 · Cited by 692
Self-citationLong-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species
Montay-Gruel, P., Acharya, M. M., Petersson, K., Alikhani, L., Yakkala, C., Allen, B. D., Ollivier, J., Petit, B., Jorge, P. G., Syage, A. R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901777116 · Cited by 599
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Biological effects in normal cells exposed to FLASH dose rate protons
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Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System
Patriarca, A., Fouillade, C., Auger, M., Martin, F., Pouzoulet, F., Nauraye, C., Heinrich, S., Favaudon, V., Meyroneinc, S., Dendale, R., et al. (2018) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2018.06.403 · Cited by 267
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Cited by
MDM2/X inhibitors as radiosensitizers for glioblastoma targeted therapy
Miles, X., Vandevoorde, C., Hunter, A., & Bolcaen, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.703442 · Cited by 40
Metadata
- Authors
- Bourhis, J., Montay-Gruel, P., Gonçalves Jorge, P., Bailat, C., Petit, B., Ollivier, J., Jeanneret-Sozzi, W., Ozsahin, M., Bochud, F., Moeckli, R., Germond, J.-F., & Vozenin, M.-C.
- Venue
- Radiotherapy and Oncology
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 139
- Pages
- 11-17
- ISSN
- 0167-8140 (ISSN-L)
- OpenAlex
- W2955197368
- Cited by
- 474
- References
- 12
- FWCI
- 47.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bourhis, J., Montay-Gruel, P., Gonçalves Jorge, P., Bailat, C., Petit, B., Ollivier, J., Jeanneret-Sozzi, W., Ozsahin, M., Bochud, F., Moeckli, R., Germond, J.-F., & Vozenin, M.-C. (2019). Clinical translation of FLASH radiotherapy: Why and how? Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2019.04.008
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