The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species
Open accessAbstract
Significance: Ultra-high dose-rate (≥100 Gy⋅s −1 ) irradiation, termed FLASH radiotherapy, affords some remarkable (if not unexpected) normal tissue sparing in the irradiated brain when compared with conventional dose rates (0.07–0.1 Gy⋅s −1 ) used in clinical practice. Radiation-induced neurocognitive deficits, persistent neuroinflammation, and the structural degradation of mature neurons, typical of conventional dose-rate exposures, were resolved significantly in a preclinical mouse model exposed to FLASH radiotherapy. These benefits persisted over a 6-mon postirradiation interval and were caused, in part, by a mechanism involving reduced reactive oxygen species. Since normal tissue injury during and following radiotherapy dictates the maximum tolerated dose, the capability to ameliorate these adverse side effects holds significant promise for improving therapeutic outcome for cancer survivors worldwide.
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Cites
Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1×
“Deficits in this behavior have been linked to the infralimbic region of the mPFC and require active unlearning, thereby providing another measure of cognitive flexibility, or the ability to adapt to a changing environment (10, 47, 55, 56).”
BackgroundElimination of microglia improves cognitive function following cranial irradiation
Acharya, M. M., Green, K. N., Allen, B. D., Najafi, A. R., Syage, A., Minasyan, H., Le, M. T., Kawashita, T., Giedzinski, E., Parihar, V. K., et al. (2016) · Scientific Reports · doi:10.1038/srep31545 · Cited by 259 · cited 2×
“A breadth of past work from our laboratories has linked adverse neurocognitive outcomes following cranial irradiation to a range of neuropathologies, including reductions in dendritic complexity and spine density (9–12), reductions in microvascular density (13– 15), reduced myelination and synapse density, and increas…”
BackgroundMethodSelf-citationCosmic radiation exposure and persistent cognitive dysfunction
Parihar, V. K., Allen, B. D., Caressi, C., Kwok, S., Chu, E., Tran, K. K., Chmielewski, N. N., Giedzinski, E., Acharya, M. M., Britten, R. A., et al. (2016) · Scientific Reports · doi:10.1038/srep34774 · Cited by 221
Self-citationParihar, V. K., Maroso, M., Syage, A., Allen, B. D., Angulo, M. C., Soltesz, I., & Limoli, C. L. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.03.009 · Cited by 127
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Clinical translation of FLASH radiotherapy: Why and how?
Bourhis, J., Montay-Gruel, P., Gonçalves Jorge, P., Bailat, C., Petit, B., Ollivier, J., Jeanneret-Sozzi, W., Ozsahin, M., Bochud, F., Moeckli, R., et al. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.04.008 · Cited by 474
Self-citationFLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence
Fouillade, C., Curras-Alonso, S., Giuranno, L., Quelennec, E., Heinrich, S., Bonnet-Boissinot, S., Beddok, A., Leboucher, S., Karakurt, H. U., Bohec, M., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1440 · Cited by 303
Radiation‐induced tissue damage and response
McBride, W. H., & Schaue, D. (2020) · The Journal of Pathology · doi:10.1002/path.5389 · Cited by 155
Sex-specific cognitive deficits following space radiation exposure
Parihar, V. K., Angulo, M. C., Allen, B. D., Syage, A., Usmani, M. T., Passerat de la Chapelle, E., Amin, A. N., Flores, L., Lin, X., Giedzinski, E., et al. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.535885 · Cited by 67
Self-citationMostafavi, M., Ghazi, F., Mehrabifard, M., Alivirdiloo, V., Hajiabbasi, M., Rahimi, F., Mobed, A., Taheripak, G., Ramezani Farani, M., Huh, Y. S., et al. (2025) · Strahlentherapie und Onkologie · doi:10.1007/s00066-024-02301-y · Cited by 16
Metadata
- Authors
- Montay-Gruel, P., Acharya, M. M., Petersson, K., Alikhani, L., Yakkala, C., Allen, B. D., Ollivier, J., Petit, B., Jorge, P. G., Syage, A. R., Nguyen, T. A., Baddour, A. A. D., Lu, C., Singh, P., Moeckli, R., Bochud, F., Germond, J.-F., Froidevaux, P., Bailat, C., Bourhis, J., Vozenin, M.-C., & Limoli, C. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-05-16
- Volume
- 116
- Issue
- 22
- Pages
- 10943-10951
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2946753897
- Cited by
- 599
- References
- 5
- FWCI
- 34.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Montay-Gruel, P., Acharya, M. M., Petersson, K., Alikhani, L., Yakkala, C., Allen, B. D., Ollivier, J., Petit, B., Jorge, P. G., Syage, A. R., Nguyen, T. A., Baddour, A. A. D., Lu, C., Singh, P., Moeckli, R., Bochud, F., Germond, J.-F., Froidevaux, P., Bailat, C., . . . Limoli, C. L. (2019). Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1901777116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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