Cited by 108Abdominal vascular conditions and treatmentsGastrointestinal Bleeding Diagnosis and TreatmentIntestinal and Peritoneal Adhesions

The Etiology and Pathogenesis of Vascular Disorders of the Intestine

Paterno, Flavio, Longo, Walter E.·2008·Radiologic Clinics of North America

Abstract

Intestinal ischemia includes all the conditions in which the blood supply to the gastrointestinal tract is not adequate to its metabolic demand. Several ischemic intestinal disorders differ in clinical presentation (acute versus chronic), etiology (occlusive versus nonocclusive), pathophysiology (arterial or venous), severity (mucosal versus transmural necrosis), and location (small bowel versus large bowel). Atherosclerosis, thromboembolic disease, hypoperfusion states, and hypercoagulable disorders are the most common causes. Reperfusion, oxygen-derived free radicals, and eicosanoids contribute to the pathogenesis of bowel injury and the systemic response that occur after ischemia. The diagnosis and treatment of intestinal ischemia are still challenging despite the advances of radiology, intensive care, and surgery. This article reviews the latest data about etiology and pathophysiology of bowel ischemia to explain the bases of diagnosis and treatment of this condition.

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Crossref · 10.1016/j.rcl.2008.06.005

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Atherosclerosis, thromboembolism, hypoperfusion, hypercoagulable state, vasculitis, venous occlusion or any mechanical obstruction to the mesenteric blood vessels may lead to ischemic bowel disease.

    “Atherosclerosis, thromboembolism, hypoperfusion (as a result of arrhythmia, heart failure, shock), hypercoagulable state, vasculitis, venous occlusion or any mechanical obstruction to the mesenteric blood vessels may to lead to ISBODI[20].”

    From Ischemic bowel disease in 2021. (2021) · cites this paper as [20]

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Authors
Paterno, F., & Longo, W. E.
Affiliations
Yale University (US)
Venue
Radiologic Clinics of North America
Publisher
Elsevier BV
Published
2008-09
Volume
46
Issue
5
Pages
877-885
ISSN
0033-8389 (ISSN-L)
OpenAlex
W1971196529
Cited by
108
References
38
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 12 · 2012: 7
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Locations
  • Radiologic Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
Keywords
intestinal ischemia, mesenteric ischemia, atherosclerosis, thromboembolism, hypoperfusion, hypercoagulable disorders, ischemia-reperfusion injury, oxygen free radicals, eicosanoids, mucosal necrosis, small bowel ischemia, ischemic colitis, pathogenesis
MeSH terms
Humans, Intestines, Ischemia, Mesenteric Vascular Occlusion, Colitis, Ischemic

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