The Etiology and Pathogenesis of Vascular Disorders of the Intestine
Abstract
Intestinal ischemia includes all the conditions in which the blood supply to the gastrointestinal tract is not adequate to its metabolic demand. Several ischemic intestinal disorders differ in clinical presentation (acute versus chronic), etiology (occlusive versus nonocclusive), pathophysiology (arterial or venous), severity (mucosal versus transmural necrosis), and location (small bowel versus large bowel). Atherosclerosis, thromboembolic disease, hypoperfusion states, and hypercoagulable disorders are the most common causes. Reperfusion, oxygen-derived free radicals, and eicosanoids contribute to the pathogenesis of bowel injury and the systemic response that occur after ischemia. The diagnosis and treatment of intestinal ischemia are still challenging despite the advances of radiology, intensive care, and surgery. This article reviews the latest data about etiology and pathophysiology of bowel ischemia to explain the bases of diagnosis and treatment of this condition.
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Atherosclerosis, thromboembolism, hypoperfusion, hypercoagulable state, vasculitis, venous occlusion or any mechanical obstruction to the mesenteric blood vessels may lead to ischemic bowel disease.
“Atherosclerosis, thromboembolism, hypoperfusion (as a result of arrhythmia, heart failure, shock), hypercoagulable state, vasculitis, venous occlusion or any mechanical obstruction to the mesenteric blood vessels may to lead to ISBODI[20].”
From Ischemic bowel disease in 2021. (2021) · cites this paper as [20]
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- Authors
- Paterno, F., & Longo, W. E.
- Affiliations
- Yale University (US)
- Venue
- Radiologic Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 46
- Issue
- 5
- Pages
- 877-885
- ISSN
- 0033-8389 (ISSN-L)
- OpenAlex
- W1971196529
- Cited by
- 108
- References
- 38
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 12 · 2012: 7
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Radiologic Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- intestinal ischemia, mesenteric ischemia, atherosclerosis, thromboembolism, hypoperfusion, hypercoagulable disorders, ischemia-reperfusion injury, oxygen free radicals, eicosanoids, mucosal necrosis, small bowel ischemia, ischemic colitis, pathogenesis
- MeSH terms
- Humans, Intestines, Ischemia, Mesenteric Vascular Occlusion, Colitis, Ischemic
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