The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?
Open accessAbstract
Summary Some complement deficiencies predispose to SLE early in life. Currently, there are no known unique physiological or genetic pathways that can explain the variability in disease phenotypes, as is suggested by studies directly and indirectly comparing cohorts of children and adults with SLE. Children present with more acute illness and have more frequent renal, hematologic and central nervous system involvement at the time of diagnosis compared to adults with SLE. Almost all children require corticosteroids during the course of their disease, and many are treated with immunosuppressive drugs. Despite of a general lack of co-morbid conditions, mortality rates remain higher with pediatric SLE compared to aSLE. Children and adolescents accrue more damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, especially in the renal, ocular and musculoskeletal organ systems. Conversely, cardiovascular mortality is more prevalent in adults with SLE.
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Mortality in systemic lupus erythematosus
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Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE
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Almaani, S., Meara, A., & Rovin, B. H. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05780616 · Cited by 930
Metadata
- Authors
- Mina, R., & Brunner, H. I.
- Venue
- Rheumatic Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 36
- Issue
- 1
- Pages
- 53-80
- ISSN
- 0889-857X (ISSN-L)
- OpenAlex
- W2018455360
- Cited by
- 291
- References
- 102
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Mina, R., & Brunner, H. I. (2010). Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus? Rheumatic Disease Clinics of North America. https://doi.org/10.1016/j.rdc.2009.12.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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